Abstract
It is generally believed that the occurrence of SCE is related to DNA primary damage. Using sister chromatid exchanges as an index it may be possible to detect the mutagenecity of anti-tumor drugs aand to use this as a method for screening new drugs. In this paper we report the effect of Camptothecin, Harringtonine, Flurouracil and Mytomycin C on SCEs in human gastric carcinoma cells (SGC-7901) and lymphocytes. It was observed that all of them could increase SCE frequency in both kinds of cells. However more SCEs were induced by these drugs in SGC-7901 cells than in the normal lymphocytes and the differences were statistically significant. At a lower concentration (10-7 μg/ml), Camptothecin and Flurouracil could remarkably increase SCEs in the tumor cells but in the lymphocytes. This result is in good agreement with the fact that they are specifically used for treating stomach cancer. Therefore we consider that the method we described above may be useful for screening new anti-stomach cancer drugs.
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© 1984 Plenum Press, New York
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Ma, Z.R., Liu, Y.L., Li, C.B., Zhao, S.Y. (1984). The Induction of Sister Chromatid Exchanges in Human Gastric Carcinoma Cells and Lymphocytes Exposed to Anti-Tumor Drugs. In: Chu, E.H.Y., Generoso, W.M. (eds) Mutation, Cancer, and Malformation. Environmental Science Research, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2399-0_49
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DOI: https://doi.org/10.1007/978-1-4613-2399-0_49
Publisher Name: Springer, Boston, MA
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