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The Cellular Pathobiology of Atherosclerosis In 1983

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Drugs Affecting Lipid Metabolism VIII

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Abstract

The main components of the advanced atherosclerotic plaque are the necrotic cholesteryl ester-rich core from which the disease process gets part of its name (the Greek stem “athero” means gruel or porridge) and the fibrous (sclerotic) cap which contains predominantly smooth muscle cells which often become encased in their own synthesis products of collagen, elastin and proteoglycans. Typically, many of these cells and their surrounding intercellular matrix are associated with abundant lipids which are demonstrable both chemically and morphologically. Most of the signs and symptoms and most of the life- threatening effects of atherosclerosis are due to these major components. They result in its being the leading cause of death and morbidity in the urban-industrial countries of the world, especially in Europe and North America.

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References

  1. R. W. Wissler, Development of the atherosclerotic plaque, in: Myocardium: Failure and Infarction, E. Braunwald, ed., p. 155, H. P. Publishing Co., New York (1974).

    Google Scholar 

  2. R. W. Wissler, The emerging cellular pathobiology of atherosclerosis, Artery 5: 409 (1979).

    PubMed  CAS  Google Scholar 

  3. R. Ross, Atherosclerosis: A problem of the biology of arterial wall cells and their interactions with blood components, Arteriosclerosis 1: 293 (1981).

    Article  PubMed  CAS  Google Scholar 

  4. D. Steinberg, Lipoproteins and atherosclerosis: A look back and a look ahead, Arteriosclerosis 3: 283 (1983).

    Article  PubMed  CAS  Google Scholar 

  5. R. W. Wissler and D. Vesselinovitch, The pathobiology of the artherosclerotic plaque in the mid-1980s, in: “Regression of atherosclerotic lesions: Experimental studies and observations in humans,” R. Malinow and V. Blaton, eds., Plenum Press, New York (1984).

    Google Scholar 

  6. R. Ross and J. A. Glomset, The pathogenesis of atherosclerosis, New Eng. J. Med. 295: 369, 420 (1976).

    Google Scholar 

  7. R. W. Wissler, Conference on the Health Effects of Blood Lipids: Optimal Distributions for Populations, Workshop Report: Laboratory-Experimental Section, Prev. Med. 8: 175 (1979).

    Article  Google Scholar 

  8. V. C. Y. Kao, R. W. Wissler, and K. Fischer-Dzoga, The influence of hyperlipemic serum on the growth of medial smooth muscle cells of rhesus monkey aorta in vitro, Circulation 38 (Suppl. VI): 12 (1968).

    Google Scholar 

  9. K. Fischer-Dzoga and R. W. Wissler, Stimulation of proliferation in stationary primary cultures of monkey aortic smooth muscle cells, II. Effect of varying concentrations of hyperlipemic serum and low-density lipoproteins of varying dietary fat origins, Atherosclerosis 24: 515 (1976).

    Article  PubMed  CAS  Google Scholar 

  10. R. W. Wissler, Interactions of low-density lipoproteins from hypercholesterolemic serum with arterial wall cells and their extracellular products in atherogenesis and regression, in: “The Biochemistry of Atherosclerosis,” A. Scanu, R. W. Wissler, and G. S. Getz, eds., p. 345, Marcel Dekker, Inc., New York (1979).

    Google Scholar 

  11. Y. Yoshida, K. Fischer-Dzoga, and R. W. Wissler, Effects of normolipidemic high-density lipoproteins on proliferation of monkey aortic smooth muscle cells induced by hyperlipidemic low-density lipoproteins, Exp. Mol. Pathol., (In Press, 1984).

    Google Scholar 

  12. N. E. Miller, Prevention of coronary heart disease: The role of high-density lipoproteins, Postgrad. Med. J. 56: 575 (1980).

    Article  PubMed  CAS  Google Scholar 

  13. S. R. Bates, Accumulation and loss of cholesterol esters in monkey arterial smooth muscle cells exposed to normal and hyperlipemic serum lipoproteins, Atherosclerosis 32: 165 (1979).

    Article  PubMed  CAS  Google Scholar 

  14. S. R. Bates, Effect of HDL on the interaction of hyperlipemic LDL with smooth muscle cells, Artery 7: 303 (1980).

    PubMed  CAS  Google Scholar 

  15. R. W. Wissler, K. Fischer-Dzoga, S. R. Bates, and R. M. Chen, Arterial smooth muscle cells in tissue culture, in: “Structure and Function of the Circulation,” Vol. III, C. J. Schwartz, N. T. Werthessen, and S. Wolf, eds., p. 427, Plenum Press, New York (1981).

    Google Scholar 

  16. R. W. Wissler, Atherosclerosis-its pathogenesis in perspective, in: “Comparative Pathology of the Heart (Adv. Cardiol.),” Vol. 13, F. Horaberger, ed., p. 10, S. Karger, Basel (1974).

    Google Scholar 

  17. R. M. Chen, G. S. Getz, K. Fischer-Dzoga, and R. W. Wissler, The role of hyperlipidemic serum on the proliferation and necrosis of aortic medial cells in vitro, Exp. Mol. Pathol. 26: 359 (1977).

    Article  PubMed  CAS  Google Scholar 

  18. W.A. Thomas, J. M. Reiner, R. A. Florentin, K. Janakidevi, and K. J. Lee, Arterial smooth muscle cells in atherogenesis: Births, deaths and clonal phenomena, in: Atherosclerosis IV, G. Schettler, Y. Goto, Y. Hata, and G. Klose, eds., p. 16, Springer-Verlag, Berlin (1977).

    Google Scholar 

  19. R. W. Wissler, Principles of pathogenesis of atherosclerosis, in: Heart Disease: A Textbook of Cardiovascular Medicine, second edition, E. Braunwald, ed., p. 1185, W. B. Saunders Co., Philadelphia (1984).

    Google Scholar 

  20. W. C. Roberts, The status of the coronary arteries in fatal ischemic heart disease, Cardiovasc. Clin. 7: 1 (1975).

    PubMed  CAS  Google Scholar 

  21. D. B. Zilversmit, Atherogenesis: A postprandial phenomenon, Circulation Res. 33: 633 (1973).

    PubMed  CAS  Google Scholar 

  22. R. W. Mahley, Atherogenic hyperlipoproteinemia, The cellular and molecular biology of plasma lipoproteins altered by dietary fat and cholesterol, Med. Clin. N. Am. 66: 375 (1982).

    PubMed  CAS  Google Scholar 

  23. R. W. Mahley, H. Weisgraber, and T. Innerarity, Canine lipoproteins and atherosclerosis: II. Characterization of the plasma lipoproteins associated with atherogenic and non- atherogenic hyperlipidemia, Circ. Res. 35: 722 (1974).

    PubMed  CAS  Google Scholar 

  24. G. M. Fless, R. W. Wissler, and A. M. Scanu, Study of abnormal plasma low-density lipoproteins in rhesus monkeys with diet- induced hyperlipidemia, Biochemistry 15: 5799 (1976).

    Article  PubMed  CAS  Google Scholar 

  25. L. L. Rudel, L. L. Pitts, II, and C. A. Nelson, Characterization of plasma low-density lipoproteins of nonhuman primates fed dietary cholesterol, J. Lipid Res. 18: 211 (1977).

    PubMed  CAS  Google Scholar 

  26. K. V. Krishnaiah, L. F. Walker, J. Borensztajn, G. Schonfeld, and G. S. Getz, Apolipoprotein B variant derived from the rat intestine, Proc. Nat. Acad. Sci. 17: 3806 (1980).

    Article  Google Scholar 

  27. G. M. Fless, T. Kirchhausen, K. Fischer-Dzoga, R. W. Wissler, and A. M. Scanu, Relationship between the properties of the apo B containing low-density lipoproteins (LDL) of normolipidemic rhesus monkeys and their mitogenic action on arterial smooth muscle cells grown in vitro, in: “Atherosclerosis V,” A. M. Gotto, Jr., L. C. Smith, and B. Allen, eds., p. 607, Springer-Verlag, New York (1980).

    Google Scholar 

  28. G. M. Fless, T. Kirchhausen, K. Fischer-Dzoga, R. W. Wissler, and A. M. Scanu, Serum low-density lipoproteins with mitogenic effect on cultured aortic smooth muscle cells, Atherosclerosis 41: 171 (1982).

    Article  PubMed  CAS  Google Scholar 

  29. G. Assmann, Lipid Metabolism and Atherosclerosis, Schauttauer Verlag, Stuttgart (1982).

    Google Scholar 

  30. E. P. Benditt, Implications of the monoclonal character of human atherosclerotic plaques, Am. J. Pathol. 86: 693 (1977).

    PubMed  CAS  Google Scholar 

  31. J. Chamley-Campbell, G. R. Campbell, and R. Ross, The smooth muscle cell in culture, Physiol. Rev. 59: 1 (1979).

    CAS  Google Scholar 

  32. C. Gajdusek, P. Di Corleto, R. Ross, and S. M. Schwartz, An endothelial cell-derived growth factor, J. Cell. Biol. 85: 467 (1980).

    Article  PubMed  CAS  Google Scholar 

  33. S. J. Leibovich and R. Ross, A macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro, Am. J. Pathol. 84: 501 (1976).

    PubMed  CAS  Google Scholar 

  34. E. P. Benditt and J. M. Benditt, Evidence for a monoclonal origin of human atherosclerotic plaques, Proc. Nat. Acad. Sci. 70: 1753 (1973).

    Article  PubMed  CAS  Google Scholar 

  35. G. R. Campbell and J. H. Chamley-Campbell, The cellular patho-biology of atherosclerosis, Pathology 13: 423 (1981).

    Article  PubMed  CAS  Google Scholar 

  36. J. L. Goldstein and M. S. Brown, The low-density lipoprotein pathway and its relation to atherosclerosis, Ann. Rev. Biochem. 46: 897 (1977).

    Article  PubMed  CAS  Google Scholar 

  37. C. DeDuve, The participation of lysosomes in the transformation of smooth muscle cells to foamy cells in the aorta of cholesterol-fed rabbits, Acta Cardiol. Suppl. 20: 9 (1974).

    Google Scholar 

  38. J. L. Goldstein, Y. K. Ho, S. K. Basu, and M. S. Brown, A binding site on macrophages that mediates the uptake and degradation of acetylated low-density lipoprotein producing massive cholesterol deposition, Proc. Nat. Acad. Sci. 76: 333 (1979).

    Article  PubMed  CAS  Google Scholar 

  39. R. W. Wissler and D. Vesselinovitch, Atherosclerosis—relationship to coronary blood flow, Am. J. Cardiol. 52: 2A (1983).

    Google Scholar 

  40. R. W. Wissler and D. Vesselinovitch, Experimental models of human atherosclerosis, Ann. N. Y. Acad. Sci. 149: 907 (1968).

    PubMed  CAS  Google Scholar 

  41. T. Schaffner, V. M. Elner, M. Bauer, and R. W. Wissler, Acid lipase: A histochemical and biochemical study using triton X100-naphthyl palmitate micelles, J. Histochem. Cytochem. 26: 969 (1978).

    Article  Google Scholar 

  42. T. Schaffner, K. Taylor, E. J. Bartucci, K. Fischer-Dzoga, J. H. Beeson, S. Glagov, and R. W. Wissler, Arterial foam cells exhibit distinctive immunomorphologie and histochemical features of macrophages, Am. J. Pathol. 100: 57 (1980).

    PubMed  CAS  Google Scholar 

  43. D. Vesselinovitch and R. W. Wissler, Correlation of types of induced lesions with regression of coronary atherosclerosis in two species of macaques, in: “Lipoproteins and Coronary Atherosclerosis,” G. Noseda, C. Fragiacomo, R. Fumagalli, and R. Paoletti, eds., p. 401, Elsevier, Amsterdam (1982).

    Google Scholar 

  44. D. Vesselinovitch and R. W. Wissler, Quantitation of certain qualitative differences in the atherosclerotic process, in: “Atherosclerosis VI,” G. Schettler, A. M. Gotto, G. Middelhoff, A. S. Habenicht, and K. R. Jurutka, eds., p. 174, Springer-Verlag, Berlin (1983).

    Google Scholar 

  45. H. R. Davis, D. Vesselinovitch, and R. W. Wissler, Reticuloendothelial system response to hyperlipidemia in rhesus and cynomolgus monkeys, J. Leuk. Biol. (In Press, 1984).

    Google Scholar 

  46. R. W. Wissler and D. Vesselinovitch, New concepts of factors involved in the natural history and regression of atherosclerosis, Periodica Angiologica 5: 178 (1983).

    Google Scholar 

  47. A. R. Rich and J. E. Gregory, The experimental demonstration that periarteritis nodosa is a manifestation of hypersen-sitivity, Bull. Johns Hopkins Hosp. 72: 65 (1943).

    Google Scholar 

  48. H. C. Hopps and R. W. Wissler, The experimental production of generalized arteritis and periarteritis (periarteritis nodosa), J. Lab. Clin. Med. 31: 939 (1946).

    PubMed  CAS  Google Scholar 

  49. C. R. Minick, G. E. Murphy, and W. C. Cambell, Experimental induction of therosclerosis by the synergy of allergic injury to arteries and lipid-rich diet, I. Effect of repeated injection of horse serum in rabbits fed dietary cholesterol supplement, J. Exp. Med. 124: 635 (1966).

    Article  PubMed  CAS  Google Scholar 

  50. C. R. Minick and G. E. Murphy, Experimental induction of atherosclerosis by the synergy of allergic injury to arteries and lipid-rich diet, II. Effect of repeatedly injected foreign protein in rabbits fed a lipid-rich, cholesterol-poor diet, Am. J. Pathol. 73: 265 (1975).

    Google Scholar 

  51. L. M. Buja, L. D. Hillis, C. S. Petty, and J. T. Willerson, The role of coronary arterial spasm in ischemic heart disease, Arch. Pathol. Lab. Med. 105: 221 (1981).

    PubMed  CAS  Google Scholar 

  52. M. L. Armstrong and M. G. Megan, Responses of two macaque species to atherogenic diet and its withdrawal, in: “Atherosclerosis III,” G. Schettler and A. Weizel, eds., p. 336, Springer- Verlags, Berlin (1974).

    Google Scholar 

  53. W. Hollander, B. Kirkpatrick, B. Paddock, J. Colombo, M. Nagraj, and S. Prusty, Studies on the progression and regression of coronary and peripheral atherosclerosis in the cynomolgus monkey, Exp. Mol. Pathol. 30: 55 (1979).

    Article  PubMed  CAS  Google Scholar 

  54. D. Vesselinovitch, G. S. Getz, R. H. Hughes, and R. W. Wissler, Atherosclerosis 20: 303 (1974).

    Article  PubMed  CAS  Google Scholar 

  55. D. Vesselinovitch, R. W. Wissler, T. J. Schaffner, and J. Borensztajn, The effects of various diets on atherogenesis in rhesus monkeys, Atherosclerosis 35: 189 (1980).

    Article  PubMed  CAS  Google Scholar 

  56. D. Kritchevsky, S. A. Tepper, D. Vesselinovitch, and R. W. Wissler, Cholesterol vehicle in experimental atherosclerosis, Part 13, Randomized peanut oil, Atherosclerosis 17: 225 (1973).

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. The Department of Pathology and The Specialized Center of Research in Atherosclerosis, The University of Chicago, Chicago, Illinois, 60637, USA

    Robert W. Wissler

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  1. Robert W. Wissler
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Editors and Affiliations

  1. The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

    David Kritchevsky

  2. West Chester, Pennsylvania, USA

    William L. Holmes

  3. Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy

    Rodolfo Paoletti

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© 1985 Plenum Press, New York

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Wissler, R.W. (1985). The Cellular Pathobiology of Atherosclerosis In 1983. In: Kritchevsky, D., Holmes, W.L., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism VIII. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2459-1_1

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  • DOI: https://doi.org/10.1007/978-1-4613-2459-1_1

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