Abstract
Prostacyclin (PGI2) synthesis is associated with maintenance of normal vascular function, and a fall in human vascular PGI2 synthesis has been associated with atherosclerosis (1,2). It has been proposed that a decrease in PGI2 production results in the loss or impairment of the vascular defense mechanism against platelet deposition which might favor thrombosis and the progression of atherosclerosis (1). A decrease in bioassayable PGI2 production by vascular sections from fatty streak (pre-atherosclerotic) and advanced atherosclerotic lesions has been reported (3). Little if any information is available concerning the activity of prostacyclin synthetase in vascular tissue immediately adjacent to advanced atherosclerotic plaques. An increase or decrease in the PGI2 generating capacity of these adjacent areas could represent a protective mechanism against or a predisposing factor for, respectively, the progression of atherosclerotic disease into these areas.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Sinzinger H, Feigl W, Silberbauer K: Prostacyclin generation in atherosclerotic arteries. Lancet (2):469, 1979.
Gryglewski RJ, Dembinska-Kiec A, Zmuda A, Gryglewski T: Prostacyclin and thromboxane A2 biosynthesis capacities of heart, arteries and platelets at various stages of experimental atherosclerosis in rabbits. Atherosclerosis (31):385–394, 1978.
Sinzinger H, Feigl W, Silberbauer K, Oppolzer R, Winter M, Auerswald W: Prostacyclin (PGI2)-generation by different types of human atherosclerotic lesions. Exp. Pathol. (Jena) (18):175–180, 1980.
She HS, McNamara DB, Spannhake EW, Hyman AL, Kadowitz PJ: Metabolism of prostaglandin endoperoxide by microsomes from cat lung. Prostaglandins (21):531–541, 1981.
Kerstein MD, Saroyan M, McMullen-Laird M, Hyman AL, Kadowitz PJ, McNamara DB: Metabolism of prostaglandins in human saphenous vein. J. Surg. Res. (35):91–100, 1983.
McNamara DB, Hussey JL, Kerstein MD, Rosenson RJ, Hyman AL, Kadowitz PJ: Modulation of prostacyclin synthetase and unmasking of PGE2 isomerase in bovine coronary arterial microsomes. Biochem. Biophys. Res. Commun. (118):33–39, 1984.
Higgs EA, Moncada S, Vane JR, Caen JP, Michel H, Tobelem G: Effect of prostacyclin (PGI2) on platelet adhesion to rabbit arterial subendothelium. Prostaglandins (16):17–22, 1978.
McNamara DB, Rush DS, Kerstein MD, Bellan JA, Mayeux PR, Adinolfi AL, Hyman AL, Kadowitz PJ: Prostacyclin synthetase activity in normal and early and advanced atherosclerotic human carotid artery. Prostaglandins (submitted), 1984.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
McNamara, D.B. et al. (1985). Prostaglandin Endoperoxide Metabolism by the Human Carotid Artery. In: Beamish, R.E., Panagia, V., Dhalla, N.S. (eds) Pathogenesis of Stress-Induced Heart Disease. Developments in Cardiovascular Medicine, vol 46. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2589-5_28
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2589-5_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9623-2
Online ISBN: 978-1-4613-2589-5
eBook Packages: Springer Book Archive