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Cellular and Subcellular Compartmentation of Prostaglandin and Thromboxane Synthesis

  • Chapter
Biochemistry of Arachidonic Acid Metabolism

Part of the book series: Prostaglandins, Leukotrienes, and Cancer ((PLAC,volume 1))

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Abstract

A current general perception of prostaglandin synthesis and function is as follows. Prostaglandins are formed in short-lived bursts by virtually all cells in response to specific cell surface stimuli; prostaglandins then exit the cells in which they are formed and act via receptors on the surface of parent or neighboring cells to elicit responses, usually activation of adenylate cyclase. Thus, prostaglandins are viewed as local hormones or autocoids. The latter concept derives from three general observations: (a) biologically active prostaglandins are rapidly catabolized to less active 15-keto derivatives during passage through the circulation, most notably by lung and kidney (1–5); (b) the serum concentrations of prostaglandin derivatives considered to be biologically active are below those necessary to elicit myotropic responses (i.e. ≤ 10−10 M (6–9)) and (c) prostaglandins are formed by all organs and not by a central exocrine gland (10–12).

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Authors
  1. William L. Smith
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Editors and Affiliations

  1. Department of Biological Chemistry College of Medicine, University of Illinois at Chicago, 1853 W. Polk St., 60612, Chicago, IL, USA

    William E. M. Lands

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© 1985 Martinus Nijhoff Publishing, Boston

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Smith, W.L. (1985). Cellular and Subcellular Compartmentation of Prostaglandin and Thromboxane Synthesis. In: Lands, W.E.M. (eds) Biochemistry of Arachidonic Acid Metabolism. Prostaglandins, Leukotrienes, and Cancer, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2597-0_5

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  • DOI: https://doi.org/10.1007/978-1-4613-2597-0_5

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4613-2597-0

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