Skip to main content

Randomized study of chemotherapy alone vs. chemotherapy plus radiotherapy in Clinical Stages IA-IIA Hodgkin’s disease

  • Chapter
Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances

Part of the book series: Developments in Oncology ((DION,volume 32))

Abstract

Major radiotherapy centers or collaborative groups report 5-year survival rates of 80–90% or higher in patients with Stages I-IIA Hodgkin’s disease [1–4]. These results have been achieved with megavoltage equipment, variable irradiated fields (involved field to total lymphoid) and doses between 3,500 and 4,400 rad. Adjuvant chemotherapy has significantly increased relapse-free survival compared with irradiation alone (87–92% vs 66–79% at 5 years). However, 5-year survival rates are identical. Comparisons at 10 or more years remain to be determined [1, 2, 4].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 469.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 599.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 599.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hoppe RT, Coleman CN, Cox RS et al. (1982). The management of Stage I-II Hodgkin’s disease with irradiation alone or combined modality therapy: The Stanford experience. Blood 59: 455–465.

    Google Scholar 

  2. Nissen NI and Nordentoft AM (1982). Radiotherapy vs combined modality treatment of Stage I and II Hodgkin’s disease. Cancer Treat Rep 66: 799–803.

    PubMed  CAS  Google Scholar 

  3. Bergsagel DE, Alison RE, Bean HA et al. (1982). Results of treating Hodgkin’s disease without a policy of laparatomy staging. Cancer Treat Rep 66: 717–731.

    PubMed  CAS  Google Scholar 

  4. Andrieu JM, Montagnan B, Asselain B et al. (1980). Chemotherapy-radiotherapy association in Hodgkin’s disease, clinical Stages IA-III: Results of a prospective clinical trial with 166 patients. Cancer 46: 2126–2130.

    Article  PubMed  CAS  Google Scholar 

  5. Pavlovsky S, Morguenfeld M, Somoza N et al. (1981). Long term follow-up of two chemotherapy protocols in Hodgkin’s disease. Medicina (Buenos Aires) 41 (Supl): 15–21.

    Google Scholar 

  6. DeVita VT, Simon RM, Hubbard SM et al. (1980). Curability of advanced Hodgkin’s disease with chemotherapy long term follow-up of MOPP-treated patients at the National Cancer Institute. Ann Intern Med 92: 587–595.

    PubMed  Google Scholar 

  7. Kapp DS, Prosnitz LR, Farber LR et al. (1983). Patterns of failure in Hodgkin’s disease: The Yale University experience. Cancer Treat Symposia 2: 145–156.

    Google Scholar 

  8. Fuller LM and Hagemeister FB (1983). Diagnosis and management of Hodgkin’s disease in adults. Cancer 51: 2469–2476.

    Article  PubMed  CAS  Google Scholar 

  9. Olweny CLM, Katongole-Mbidde E, Kiire C et al. (1978). Childhood Hodgkin’s disease in Uganda. A ten years experience. Cancer 42: 787–792.

    Article  PubMed  CAS  Google Scholar 

  10. Ekert H and Waters KD (1983). Results of treatment of 18 children with Hodgkin’s disease with MOPP chemotherapy as the only treatment modality. Med Pediat Oncol 11: 322–326.

    Article  CAS  Google Scholar 

  11. Jacobs P, King HS, Karahus C et al. (1984). Hodgkin’s disease in children. A ten year experience in South Africa. Cancer 53: 210–213.

    Article  PubMed  CAS  Google Scholar 

  12. Schomberg PJ, Evans RG, O’Connel MJ et al. (1984). Prognostic significance of mediastinal mass in adult Hodgkin’s disease. Cancer 53: 324–328.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Martinus Nijhoff Publishers, Boston

About this chapter

Cite this chapter

Pavlovsky, S., Dupont, J., Jiménez, E., Sackmann-Muriel, F., Montero, C., Garay, G. (1985). Randomized study of chemotherapy alone vs. chemotherapy plus radiotherapy in Clinical Stages IA-IIA Hodgkin’s disease. In: Cavalli, F., Bonadonna, G., Rozencweig, M. (eds) Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances. Developments in Oncology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2607-6_35

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2607-6_35

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9632-4

  • Online ISBN: 978-1-4613-2607-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics