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Cultured Heart Cells as a Model for Studying Myocardial Ischemia

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Pathobiology of Cardiovascular Injury

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 49))

Summary

We discuss physiological, morphological and biochemical findings associated with hypoxia, active transport inhibition and metabolic inhibition to justify the use of cultured embryonic chick heart cells as a model system for studying myocardial ischemia. Measurements of ion content (Na, K, Ca), cytosolic free calcium, ATP content, LDH release and transmembrane potentials are combined with ultrastructural and electron-probe microanalyses to identify mechanisms responsible for myocardial cell injury.

This research was supported in part by NHLBI grants HL17670, HL28280, HL29687 and HL07101.

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Author information

Authors and Affiliations

  1. Department of Physiology, Duke University Medical Center, Durham, North Carolina, 27710, USA

    M. Lieberman, A. Lefurgey, E. Murphy & S. Liu

Authors
  1. M. Lieberman
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  2. A. Lefurgey
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  3. E. Murphy
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  4. S. Liu
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Editor information

Editors and Affiliations

  1. Health Sciences Center, University of Oklahoma, USA

    H. Lowell Stone

  2. Cardiovascular Research Program, Oklahoma Medical Research Foundation, USA

    William B. Weglicki

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© 1985 Martinus Nijhoff Publishing, Boston

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Lieberman, M., Lefurgey, A., Murphy, E., Liu, S. (1985). Cultured Heart Cells as a Model for Studying Myocardial Ischemia. In: Stone, H.L., Weglicki, W.B. (eds) Pathobiology of Cardiovascular Injury. Developments in Cardiovascular Medicine, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2621-2_9

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  • DOI: https://doi.org/10.1007/978-1-4613-2621-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9639-3

  • Online ISBN: 978-1-4613-2621-2

  • eBook Packages: Springer Book Archive

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