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Destruction of Tumor Cells by Macrophages: Mechanisms of Recognition and Lysis and Their Regulation

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Cancer Immunology: Innovative Approaches to Therapy

Part of the book series: Cancer Treatment and Research ((CTAR,volume 27))

Abstract

Mononuclear phagocytes, located throughout all tissues of the body, serve a multitude of major defensive and homeostatic functions [1]. One of the most important functions is the pivotal role macrophages can play in host protection against the development and spread of neoplasia [2]. Yet, the consistent and successful immunotherapy of human cancer remains an elusive goal [3]. Understanding the complex mechanisms regulating macrophage-mediated tumor cell destruction may ultimately lead to a rational basis for immunomodulation and, hence, successful immunologically based therapy of neoplastic diseases.

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Authors
  1. Scott D. Somers
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  2. William J. Johnson
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  3. Dolph O. Adams
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Editors and Affiliations

  1. Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Ronald B. Herberman M.D. (Director) (Director)

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© 1986 Martinus Nijhoff Publishers, Boston

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Somers, S.D., Johnson, W.J., Adams, D.O. (1986). Destruction of Tumor Cells by Macrophages: Mechanisms of Recognition and Lysis and Their Regulation. In: Herberman, R.B. (eds) Cancer Immunology: Innovative Approaches to Therapy. Cancer Treatment and Research, vol 27. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2629-8_3

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  • DOI: https://doi.org/10.1007/978-1-4613-2629-8_3

  • Publisher Name: Springer, Boston, MA

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