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Role of cell-surface receptors in the behaviour in vivo of transferren

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Pathophysiology of Plasma Protein Metabolism

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Abstract

Conceptualisation of plasma proteins as a physiological entity was made possible by the prior establishment of two fundamental facts: (1) that proteins are in a dynamic equilibrium with respect to synthesis and catabolism1 and (2) that plasma proteins escape in the extravascular space, from which they recirculate via the lymphatics2–4. As the result of a surge in modelling activity that has followed these discoveries, the mammalian body soon became envisaged as a set of interconnecting tanks (‘compartments’), among which proteins move to and from in a rather inert fashion. Cells played an undistinguished role in this biophysical perpetuum mobile: although they were appreciated as the source of new protein molecules, yet a plasma protein, once secreted, was supposed to remain in the extracellular space until termination of its life span under poorly understood circumstances—presumably because of cellular ingestion. Put in another way, the intracellular space was not considered part of the normal tissue distribution of a plasma protein. (A notable exception to this way of thinking was IgG, which will be dealt with further below.)

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  1. CNR Institute of Clinical Physiology, Fifth Medical Pathology of the University of Pisa, Pisa, Italy

    Giuliano Mariani

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Regoeczi, E. (1984). Role of cell-surface receptors in the behaviour in vivo of transferren. In: Mariani, G. (eds) Pathophysiology of Plasma Protein Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2793-6_19

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