Abstract
The transfusion of blood and its components is a widely used form of supportive therapy and this field has expanded greatly in recent years due to the development of more intensive treatment modalities. This is particularly true for patients with malignant diseases, where the application of high dose cytotoxic therapy often results in periods of severe bone marrow depression. This has stimulated the development of a sophisticated platelet and granulocyte substitution therapy. However, we must bear in mind that a significant number of transfusions are complicated by adverse effects and in fact patients still die from fatal transfusion reactions.
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References
Taswell, H.F., Pineda, A.A., Moore, S.B. Hemolytic transfusion reactions: frequency and clinical and laboratory aspects. In: Bell, C.A. (ed.) A seminar on immune-media ted cell destruction. Am. Assoc. Blood Banks, 1981, pp. 71–92.
Baker, R.J., Moinichen, S.L., Nyhus, L.M. Transfusion reaction: a reappraisal of surgical incidence and significance. Ann. Surg. 1969;169:684–93.
Honig, C.L., Bove, J.R. Transfusion-associated fatalities: Review of bureau of biologic reports 1976–1978. Transfusion 1980;20:631–61.
Thulstrup, H. The influence of leukocyte and thrombocyte incompatibility on non-haemolytic transfusion reactions. Vox Sang 1971;21:233–50.
Brittingham, T.E., Chaplin, H. The antigenicity of normal and leukemic human leukocytes. Blood 1961;17:139–65.
Kevy, S.V., Schmidt, P.J., McGinniss, M.H., Workman, W.G. Febrile, nonhemolytic transfusion reactions and the limited role of leuko-agglutinins in their etiology. Transfusion 1962;2:27–16.
Vyas, G.N., Holmdahl, L., Perkins, H.A., Fudenberg, H.H. Serologic specification of human anti-IgA and its significance in transfusion. Blood 1969;34:573–81.
Mcleod, B.C., Sassetti, R.J., Weens, J.H., Vaithianathan, T. Haemolytic transfusion reaction due to ABO incompatible plasma in a platelet concentrate. Scand.J.Haematol. 1982;28:193–6.
Shulman, N.R., Aster, R.H., Leitner, A., Hiller, M.C. Immunoreactions involving platelets. V. Post-transfusion purpura due to a complement-fixing antibody against a genetically controlled platelet antigen. A proposed mechanism for thrombocytopenia and its relevance in autoimmunity. J. Clin. Invest. 1961;40:1597–1620.
Abramson, N., Eisenberg, P.D., Aster, R.H. Post-transfusion purpura: immunologic aspects and therapy. N. Engl. J. Med. 1974;291:1163–6.
Dutcher, J.P., Schiffer, CA., Aisner, J., Wiernik, P.H. Long-term follow-up of patients with leukemia receiving platelet transfusions: Identification of a large group of patients who do not become alloimmunized. Blood 1981;58:1007–11.
Tejada, F., Bias, W.B., Santos, G.W., Zieve, P.D. Immunologic response of patients with acute leukemia to platelet transfusions. Blood 1973;42:405–12.
Diepenhorst, P., Engelfriet, C.P. Removal of leukocytes from whole blood and erythrocyte suspensions by filtration through cotton wool. V. Results after transfusion of 1,820 units of filtered erythrocytes. Vox Sang 1975;29:15–22.
Sintnicolaas, K., Vriesendorp, H.N., Sizoo, W. et. al. Delayed alloimmunization by random single donor platelet transfusions. A randomized study to compare single donor and multiple donor platelet transfusions in cancer patients with severe thrombocytopenia. Lancet 1981;1:750–4.
Eernisse, J.G., Brand, A. Prevention of platelet refractoriness due to HLA antibodies by administration of leukocytepoor blood components. Exp. Hematol. 1981;9:77–83.
Djerassi, I., Kim, J.S., Suvansri, U., Ciesielka, W., Lohrke, J. Filtration leukopheresis: principles and techniques for harvesting and transfusion of filtered granulocytes and monocytes. In: Goldman, J.H., Lowenthal, R.M. (eds.) Leukocytes: separation, collection and transfusion. Academic Press, New York, 1975, pp. 123–36.
Higby, D.J., Freeman, A., Henderson, E.S., Sinks, L., Cohen, E. Granulocyte transfusions in children using filter-collected cells. Cancer 1976;38:1407–13.
Ward, H.N. Pulmonary infiltrates associated with leukoagglutinin transfusion reactions. Ann. Intern. Med. 1970;73:689–94.
Higby, D.J., Burnett, D. Granulocyte transfusions: current status. Blood 1980;55:2–8.
Weiden, P.L., Zuckerman, N., Hansen, J.A., et. al. Fatal graft-versus-host disease in a patient with lymphoblastic leukemia following normal granulocyte transfusions. Blood 1981;57:328–32.
Dinsmore, R.E., Straus, D.J., Pollack, M.S. et. al. Fatal graft-versus-host disease following blood transfusion in Hodgkin’s disease documented by HLA typing. Blood 1980;55:831–4.
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© 1984 Martinus Nijhoff Publishers, Boston
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Sintnicolaas, K. (1984). Transfusion Reactions. In: Sibinga, C.T.S., Das, P.C., Taswell, H.F. (eds) Quality Assurance in Blood Banking and Its Clinical Impact. Developments in Hematology and Immunology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2835-3_16
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DOI: https://doi.org/10.1007/978-1-4613-2835-3_16
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