Abstract
Sir Edward Mellanby (1920) first demonstrated that cod-liver oil could prevent rickets. Mellanby (1920) named this antirachitic material “fat soluble vitamin D.” In retrospect it is tragic that this extremely potent sterol was classified as a vitamin; its reclassification as a potent, carefully controlled hormone should be seriously considered (Loomis, 1967). There is a mass of published information on the toxic effects of excesses of vitamin D on the arterial system in man (Forfar et al., 1956; Taussig, 1966; Seelig, 1969; Taylor et al., 1972 and Scientific reviews (GRAS) food ingredients — vitamin D, NTIS, U.S. Department of Commerce, 1974) and animals (Hass et al., 1958; Bajwa et al., 1971; Scientific reviews (GRAS) food ingredients — vitamin D, NTIS, U.S. Department of Commerce, 1974; Liu et al., 1979 and Peng et al., 1978).
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References
Avioli, L.V., Lee, S.W., McDonald, J.E., Lund, J. and De Luca, H.F., 1967, Metabolism of vitamin D3 - 3H in human subjects: Distribution in blood, bile, feces and urine, J. Clin. Invest., 46:983.
Bajwa, G.S., Morrison, L.M. and Ershoff, B.H., 1971, Induction of aortic and coronary athero-arteriosclerosis in rats fed a hypervitaminosis D, cholesterol-containing diet, Proc. Soc. Exptl. Biol. Med., 138:975.
Fomon, S.J., Chairman, Committee on Nutrition, Am. Academy of Pediatrics, 1963, The prophylactic requirement and the toxicity of vitamin D, Pediatrics (Springfield) 31:512.
Forfar, J.O., Balf, C.L., Maxwell, G.M. and Tompsett, S.L., 1956, Idiopathic hypercalcemia of infancy, Clinical and metabolic studies with special reference to the aetiological role of vitamin D, Lancet, 1:981.
Graham, S., 1959, Idiopathic hypercalcemia, Postgrad. Med., 25:67.
Hass, G.M., Trueheart, R.E., Taylor, C.B. and Stumpe, M., 1958, An experimental histologic study of hypervitaminosis D, Amer. J. Pathol., 36:295.
Hass, G.M., Trueheart, R.E. and Hemmens, A., 1960, Production of calcific atheroarteriosclerosis and thromboarteritis with nicotine, vitamin D and dietary cholesterol, Am. J. Pathol., 49:739.
Jeans, P.C., 1950, Vitamin D, JAMA, 143:177.
Kummerow, F.A., Cho, C.H.S., Huang, W.Y.T., Imai, H., Kamio, A., Deutsch, M.J. and Hooper, W.M., 1976, Additive risk factors in atherosclerosis, Am. J. Clin. Nutr., 29:579.
Kummerow, F.A., 1979, Nutrition imbalance and angiotoxins as dietary risk factors in coronary heart disease, Am. J. Clin. Nutr., 32:58.
Lehner, N.D.M., Bullock, B.C., Clarkson, T.B. and Lofland, H.B., 1967, Biologic activities of vitamin D2 and D3 for growing squirrel monkeys, Lab. Anim. Care, 17:483.
Lightwood, R. (Chairman), Sheldon, W., Harris, C. and Stapleton, T., (Committee for Study of Hypercalcemia in Infants and Vitamin D), 1956, Hypercalcemia in infants and vitamin D, Brit. Med. J., 2:149.
Lightwood, R. and Stapleton, T., 1957, National policies for the prevention of rickets, Ann. Pediat., 188:1957.
Liu, L.B., Taylor, C.B., Peng, S.K. and Mikkelson, B., 1979, Experimental arteriosclerosis in Rhesus monkeys induced by multiple risk factors: cholesterol, vitamin D and nicotine, Arterial Wall, 5:25.
Loomis, W.F., 1967, Skin-pigment regulation of vitamin D biosynthesis in man. Variation in solar ultraviolet at different latitudes may have caused racial differentiation in man, Science, 157:501.
Mellanby, E., 1920, Accessory food factors (vitamins) in the feeding of infants, Lancet, 1:856.
Meyer, W.W. and Stelzig, H.H., 1968, Calcification patterns of the internal elastic membrane, Calc. Tiss. Res., 3:266.
Peng, S.K., Taylor, C.B., Tham, P. and Mikkelson, B., 1978, Role of mild excesses of vitamin D3 in arteriosclerosis. A study in squirrel monkeys, Arterial Wall, 4:229.
Scientific literature reviews on generally recognized as safe (GRAS) food ingredients - vitamin D, 1974, Washington, D.C., Natl. Tech. Information Serv., U.S. Dept. of Commerce, July.
Seelig, M.S., 1969, Vitamin D and cardiovascular, renal and brain damage in infancy and childhood, Annals N.Y. Acad. of Sciences, 147:537.
Taussig, H.B., 1966, Possible injury to cardiovascular system from vitamin D, Ann. Intern. Med., 65:1195.
Taylor, C.B., Hass, G.M., Ho, K.J. and Liu, L.B., 1972, Risk factors in the pathogenesis of arteriosclerotic heart disease and generalized atherosclerosis, Ann. Clin. Lab. Sc., 2:239.
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© 1980 Plenum Press, New York
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Taylor, C.B., Peng, SK. (1980). Vitamin D — Its Excessive Use in the U.S.A.. In: Brewster, M.A., Naito, H.K. (eds) Nutritional Elements and Clinical Biochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3168-1_5
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DOI: https://doi.org/10.1007/978-1-4613-3168-1_5
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