Abstract
The uterine lumen is for the most part an inhospitable place for cells to grow, even cells of highly malignant tumors (Short and Yoshinaga, 1967). Only for a relatively short period following ovulation does the uterus tolerate the proliferation of nonuterine cells, and when these cells are those of the developing embryo, there may be even more subtle restrictions imposed that are stage specific, at least in some species (Chang, 1950). An understanding of the hormonally regulated alteration between “hostility” and “receptivity” in the uterus is a crucial question and a topic of primary importance to the field of mammalian implantation.
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References
Chang, M. C., 1950, Development and fate of transferred rabbit ova or blastocyst in relation to the ovulation time of recipients, J. Exp. Zool. 114: 197.
Davidson, E. H., and Britten, R. J., 1979, Regulation of gene expression: Possible role of repetitive sequences. Science 204: 1052.
Short, R. V., and Yoshinaga, K., 1967, Hormonal influences on tumour growth in the uterus of the rat, J. Reprod. Fertil. 14: 287.
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© 1981 Plenum Press, New York
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Manes, C. (1981). Introduction. In: Glasser, S.R., Bullock, D.W. (eds) Cellular and Molecular Aspects of Implantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3180-3_18
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DOI: https://doi.org/10.1007/978-1-4613-3180-3_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3182-7
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