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Comparative Mutagenicity of Dimethylnitrosamine and Diethylnitrosamine

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Comparative Chemical Mutagenesis

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Abstract

The dialkyl nitrosamines, of which dimethylnitrosamine and diethylnitrosamine are good examples, belong to the larger class of N-nitroso compounds, many of which are potent carcinogens in a large variety of animal species. In 1954 Barnes and Magee (1) demonstrated that dimethylnitrosamine was acutely hepatotoxic to laboratory animals. Subsequently, in 1956 they showed (2) that dimethylnitrosamine fed to rats produced a very high incidence of malignant liver tumor. These studies provided the impetus for extensive research on a whole range of nitroso compounds including their carcinogenity, pharmacology, chemistry, biochemistry, and mutagenic potential. The prodigious amount of literature that has accumulated in these different areas has been summarized in a number of excellent reviews (3–15).

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Authors and Affiliations

  1. Department of Radiation Genetics and Chemical Mutagenesis Sylvius Laboratories, State University of Leiden, Wassenaarseweg 72, Leiden, The Netherlands

    K. Sankaranarayanan

  2. The J. A. Cohen Institute Interuniversity Institute for Radiopathology and Radiation Protection, The Netherlands

    K. Sankaranarayanan

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  1. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Frederick J. De Serres  & Michael D. Shelby  & 

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Sankaranarayanan, K. (1981). Comparative Mutagenicity of Dimethylnitrosamine and Diethylnitrosamine. In: De Serres, F.J., Shelby, M.D. (eds) Comparative Chemical Mutagenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3409-5_27

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