Abstract
Gangliosides are amphiphilic biological lipids, having a hydrophilic part made of an oligosaccharide chain containing one or more molecules of sialic acid, and a hydrophobic part made of two long aliphatic chains belonging to a sphingosine and a fatty acid residue. The interactions of gangliosides with biological molecules and membranes may be considerably influenced by the state of aggregation of ganglioside molecules. In this review, the available experimental information about the micellar properties of gangliosides is collected and critically compared. The most significant data are the following: the probable value of the critical micelle concentration is in the range 10-10 − 10-8 M, the aggregation number is between 200 and 350, the hydrodynamic radius is about 60 Å, and the micellar shape is probably an oblate ellipsoid (disklike micelle) with an axial ratio about 2. The properties of mixed micelles with a non-ionic commercial amphiphile, Triton X-100, are also discussed.
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© 1982 Plenum Press, New York
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Corti, M., Degiorgio, V., Ghidoni, R., Sonnino, S. (1982). Micellar Properties of Gangliosides. In: Mittal, K.L., Fendler, E.J. (eds) Solution Behavior of Surfactants. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3491-0_30
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DOI: https://doi.org/10.1007/978-1-4613-3491-0_30
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