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Voltage Clamp Studies Of Calcium Channel Blockage in the Heart

  • Chapter
Calcium Antagonists

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 39))

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Abstract

It is now recognized that calcium channels exist in a wide variety of cells and participate in many aspects of cellular function (for review, see refs. 1 and 2). In the heart, voltage-dependent calcium ion influx underlies spontaneous activity and impulse conduction in the sinoatrial and atrioventricular nodes, maintains the plateau phase of ventricular action potentials, and is closely associated with activation of contraction (3–6). Thus, it is not surprising that compounds which block calcium channels are of considerable interest to cellular electrophysiologists and, in particular, to those interested in the electrophysiology of the heart.

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Authors
  1. R. S. Kass
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  2. M. C. Sanguinetti
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, M.L. 576, 45267, Cincinnati, OH, USA

    Nicholas Sperelakis

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© 1984 Martinus Nijhoff Publishing, Boston

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Kass, R.S., Sanguinetti, M.C. (1984). Voltage Clamp Studies Of Calcium Channel Blockage in the Heart. In: Sperelakis, N., Caulfield, J.B. (eds) Calcium Antagonists. Developments in Cardiovascular Medicine, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3810-9_4

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  • DOI: https://doi.org/10.1007/978-1-4613-3810-9_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3812-3

  • Online ISBN: 978-1-4613-3810-9

  • eBook Packages: Springer Book Archive

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