Abstract
Patients undergoing bone marrow transplantation for hematologic disorders are severely immunocompromised by the intensive chemotherapy and total body irradiation used in preparation for the transplant. Interstitial pneumonia occurs as a complication in approximately 40% of all bone marrow transplant recipients and is fatal in 70% of cases (1–3). Cytomegalovirus (CMV) is the most common pathogen associated with the interstitial pneumonia and can be identified in 50–70% of cases.
Supported by grants CA-23175, from the National Cancer Institute and by grant RR-865 from the Public Health Service. Dr. Champlin is a recipient of a New Investigator Research Award, National Institute of Arthritis, Diabetes and Kidney Disease. Dr. Gale is the Meyerhoff Visiting Scientist of the Weizman Institute of Science.
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References
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Ho, W.G., Winston, D.J., Champlin, R.E., Gale, R.P. (1984). CMV Infection and its Prevention with Specific Immunoglobulins. In: Smit Sibinga, C.T., Das, P.C., Opelz, G. (eds) Transplantation and Blood Transfusion. Developments in Hematology and Immunology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3840-6_9
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