Skip to main content
SpringerLink
Log in

Tumor Cell and Host Response Parameters in Designing Brain Tumor Therapy

  • Chapter
Oncology of the Nervous System

Part of the book series: Cancer Treatment and Research ((CTAR,volume 12))

Abstract

In the study of patients with malignant brain tumors, there are certain cell biological and immunological parameters which may prove useful as adjuncts in the diagnostic and therapeutic approaches to these patients. This chapter deals with certain selected biological tumor cell characteristics and host cell response factors which bear upon understanding how such parameters may influence clinical care. Important cell biological factors include tumor cell growth characteristics, malignant potential, and the cellular basis of sensitivity or resistance to chemotherapeutic agents. Host response factors are comprised of the humoral and cellular responses of brain tumor patients to their own tumors and the clinical significance and/or effectiveness of these defense mechanisms.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Reference

  1. Holmes HL, Little JM: Tissue culture microtest for predicting response of human cancer to chemotherapy. Lancet 2: 985–987, 1974.

    Article  PubMed  CAS  Google Scholar 

  2. Rosenblum ML, Knebel KD, Vasquez DA, Wilson CB: Brain tumor therapy: Quantitative analysis using a model system. J Neurosurg 46: 145–154, 1977.

    Article  PubMed  CAS  Google Scholar 

  3. Salmon SE, Hamburger AW, Sochnlen B, Durie BGM, Alberts DS, Moon TE: Quantitation of differential sensitivity of human-tumor stem cells to anticancer drugs. N Engl J Med 298: 1321–1327, 1978.

    Article  PubMed  CAS  Google Scholar 

  4. Kornblith PL, Szypko PE: Variations in response of human brain tumors to BCNU in vitro. J Neurosurg 48: 580–586, 1978.

    Article  PubMed  CAS  Google Scholar 

  5. Kornblith PL, Dohan FC Jr, Wood WC, Whitman BO: Human astrocytoma: Serum-mediated immunologic response. Cancer 33: 1512–1519, 1974.

    Article  PubMed  CAS  Google Scholar 

  6. Kornblith PL: Complement-mediated microcytotoxicity of adherent tissue-cultured cells. In: Serologic analysis of human cancer antigens, Rosenberg S. (ed), Academic Press, Inc., New York, 1980, pp 591–594.

    Google Scholar 

  7. Pfreundschuh M, Shiku H, Takahashi T, Veda R, Ransohoff J, Oettgën HF, Old LJ: Serological analysis of cell surface antigens of malignant human brain tumors. Proc Natl Acad Sei 75: 5122–5126, 1978.

    Article  CAS  Google Scholar 

  8. Wood WC, Kornblith PL, Quindlen EA, Pollock LA: Detection of humoral immune response to human brain tumors. Cancer 43: 86–90, 1979.

    Article  PubMed  CAS  Google Scholar 

  9. Coakham HB, Kornblith PL: Serologic analysis of solid tumor antigens: Immune adherence studies on human gliomas. In: Serologic analysis of human cancer antigens, Rosenberg S. (ed), Academic Press, Inc., New York, 1980, pp 65–90.

    Google Scholar 

  10. Black PM, Callahan LV and Kornblith PL: Tissue cultures from cerebrospinal fluid specimens in the study of human brain tumors. J Neurosurg 49: 697–704, 1978.

    Article  PubMed  CAS  Google Scholar 

  11. Kornblith PL, Pollock LA, Coakham HE, Quindlen EA, Wood WC: Cytotoxic antibody responses in astrocytoma patients: an improved allogeneic assay. J Neurosurg 51: 47–52, 1979.

    Article  PubMed  CAS  Google Scholar 

  12. Kornblith PL, Smith BH, Leonard LA: Response of cultured human brain tumor to nitrosoureas: Correlation with clinical data. Cancer 47: 255–265, 1980.

    Article  Google Scholar 

  13. Coakham HB, Kornblith PL: The humoral immune response of patients to their gliomas. Acta Neurochir, Suppl 28: 475–479, 1979.

    CAS  Google Scholar 

  14. Black PMcL, Kornblith PL: Biophysical properties of human astrocytic brain tumor cells in cell culture. J Cell Physiol 105: 565–570, 1980.

    Article  PubMed  CAS  Google Scholar 

  15. Lightbody J, Pfeiffer SE, Kornblith PL, Herschman H: Biochemically differentiated clonal human glial cells in tissue culture. J Neurobiol 1: 411–417, 1970.

    Article  PubMed  CAS  Google Scholar 

  16. Trachtenburg MC, Kornblith PL, Hauptli J: Biophysical properties of cultured human glial cells. Brain Res 38: 279–298, 1972.

    Article  Google Scholar 

  17. Kornblith PL: Role of tissue culture in prediction of malignancy. Clin Neurosurg 25: 346–376, 1978.

    PubMed  CAS  Google Scholar 

  18. Madoff S, Paches WN: Mycoplasma and the L forms of bacteria. In: Rapid diagnostic methods in medical microbiology, Graber C (ed), Baltimore, Williams and Wilkins, 1970.

    Google Scholar 

  19. DelGuidice RA, Hopps HE: Microbiological methods and fluorescent microscopy for the direct demonstration of mycoplasma infection of cell cultures. Proceedings of the Institute for Medical Research Workshop on Mycoplasma Infection of Cell Cultures (In press).

    Google Scholar 

  20. Kline TS: Cytological examination of the cerebrospinal fluid. Cancer 15: 591–597, 1962.

    Article  PubMed  CAS  Google Scholar 

  21. Barker BE, Sanford KK: Cytologic manifestations of neoplastic transformation in vitro. J Natl Cancer Inst 44: 39–63, 1970.

    PubMed  CAS  Google Scholar 

  22. Smith BH, Liszczak T, Pleasants ER, Kornblith PL: Modulation of cAMP-induced process for-mation and con-A induced cap formation in a human glioma line. Neurosci Soc Abstr IV: 596, 1978.

    Google Scholar 

  23. Gumerlock MK, Smith BH, Pollock LA, Kornblith PL: Chemical differentiation of cultured human glioma cells: Morphologic and immunologic effects. Surg Forum XXXII: 445–477, 1981.

    Google Scholar 

  24. Shitara N, McKeever P, Whang Peng J, Smith BH, Schmidt S, Kornblith PL: Cytofluorometric DNA determination and cytogenetic analysis in human cultured cell lines derived from brain tumors. (Submitted).

    Google Scholar 

  25. McKeever PE, Quindlen E, Banks MA, Williams U, Kornblith PL, Laverson S, Greenwood MA, Smith BH: Biosynthesized products of cultured neuroglial cells: I. Selective release of proteins by cells from human astrocytomas. Neurology 31: 1445–52, 1981.

    PubMed  CAS  Google Scholar 

  26. Cummins CJ, Galarraga J, DeLaPaz R, Smith BH, Passonneau JV, DiChiro G, Kornblith PL: Some aspects of the aerobic and anaerobic metabolism of human astrocytoma III and IV in culture (In preparation).

    Google Scholar 

  27. Dohan FC Jr, Kornblith PL, Wellum GR, Pfeiffer SE, Levine L: S-100 protein and 2’, 3’-cyclic nucleotide 3’-phosphohydrolase in human brain tumors. Acta Neuropathol (Berl) 40: 123–128, 1977.

    Article  CAS  Google Scholar 

  28. Laverson S, McKeever PE, Kornblith PL, Quindlen E, Howard R: Diagnosis of glioma on frozen section by immunofluorescence for glial fibrillary acidic protein. Lancet 1: 674, 1981.

    Article  PubMed  CAS  Google Scholar 

  29. Scott RM, Liszczak TM, Kornblith PL: ‘Invasiveness’ in tissue culture: A technique for the study of gliomas. Surg Forum 29: 531–533, 1978.

    PubMed  CAS  Google Scholar 

  30. Smith BH, Ellis J, Pacheco M, Brown K, Kornblith PL: Automated image analysis of microtiter plate chemotherapy and immunological assays. (In preparation).

    Google Scholar 

  31. Levin VA, Hoffman W, Weinkam J: Pharmacokinetics of BCNU in man: A preliminary study of 20 patients. Cancer Treat Rep 62: 1305–1312, 1978.

    PubMed  CAS  Google Scholar 

  32. DeVita VA, Denham C, Davidson JD, Oliverio VT: The physiological disposition of the car-cinostatic 1,3-bis (2-chloroethyl)-l-nitrosourea (BCNU) in man and animals. Clin Pharm Ther 8: 566–577, 1967.

    CAS  Google Scholar 

  33. Dickson J A, Suzangar M: In vitro sensitivity testing of human tumour slices to chemotherapeutic agents — its place in cancer therapy. In: Human tumours in short term culture, Dendy PP (ed), Academic Press, Inc., New York, pp 107–138, 1976.

    Google Scholar 

  34. Smith BH, Cooke C, Leonard L, Kornblith PL: Solid phase testing of chemotherapy agents (In preparation).

    Google Scholar 

  35. Hochberg FH, Linggood R, Wolfson L, Baker WH, Kornblith PL: Quality and duration of survival in glioblastoma multiforme. JAMA 24: 1016–1018, 1979.

    Article  Google Scholar 

  36. Kornblith PL, Coakhan HB, Pollock LA, Ward W, Green S, Smith BH: Autologous serological responses in glioma: Correlation with tumor grade and survival (In press). Cancer, 1983.

    Google Scholar 

  37. Tachibana T, Klein E: Detection of cell surface antigens on monolayer cells. I. The application of immune adherence in microscale. Immunology 19: 771–782, 1970.

    PubMed  CAS  Google Scholar 

  38. Coakham HB, Kornblith PL, Quindlen EA, Pollock LA, Wood WC, Hartnett LC: Autologous humoral response to human gliomas and analysis of certain cell surface antigens: In vitro study with the use of microcytotoxicity and immune adherence assays. J Natl Cancer Inst 64: 223–233, 1980.

    PubMed  CAS  Google Scholar 

  39. Boyum A: Isolation of mononuclear cells and granulocytes from peripheral blood. Scand J Clin Lab Invest 21, Suppl 97: 77–89, 1968.

    CAS  Google Scholar 

  40. Perper RJ, Zee TW, Mickelson MM: Purification of lymphocytes and platelets by gradient cen-trifugation. J Lab Clin Med 72: 842–848, 1968.

    PubMed  CAS  Google Scholar 

  41. Lozzio CB, Lozzio BB: Cytotoxicity of a factor isolated from human spleen. J Natl Cancer Inst 50: 535–538, 1973.

    PubMed  CAS  Google Scholar 

  42. Herberman RB, Holden HT: Natural cell-mediated immunity. Adv Cancer Res 27: 305–377, 1978.

    Article  PubMed  CAS  Google Scholar 

  43. Rankin JK, Shapiro WR, Posner JB: Cellular stability and chromosomal evolution of early passage cells from human gliomas. Proceedings, American Association for Cancer Research. Abst. 21: 55, 1980.

    Google Scholar 

  44. Bigner DD, Bigner SH, Ponten J, Westermark B, Mahaley MS, Rouslahti E, Herschman H, Eng LF, Wikstrand CJ: Heterogeneity of genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas. J Neuropath and Exp Neurol 40: 201–229, 1981.

    Article  CAS  Google Scholar 

  45. Pfeiffer SE, Sundarra N, Dawson G, Kornblith PL: Human acoustic neurinomas: nervous system specific biochemical parameters. Acta Neuropathol (Berl.) 47: 27–31, 1979.

    Article  CAS  Google Scholar 

  46. DeLaPaz R, DiChiro G, Smith BH, Kornblith PL, Quindlen EA, Sokoloff L, Brooks RA, Kessler RM, Johnston GS, Manning RG, Flynn RM, Wolf AP, Fowler JS, Brill B, Blasberg RG, London WT, Sever JL, Kufta CV, Rieth KG, Goble JC, Cummins C: 18F-2-fluoro-2-deoxy- glucose positron emission tomography of human cerebral gliomas. Scientific Manuscripts, AANS, 29–30, 1981.

    Google Scholar 

  47. Kornblith PL, Quindlen EA, Pollock LA, Coakham HB: Humoral Immunology of Brain Tumors. In: Multidisciplinary aspects of brain tumors therapy, Paoletti P, Walker MD, Butti G, Knerich R (eds), Elsevier/North-Holland, New York, 113–122, 1979.

    Google Scholar 

  48. Brooks WH, Netsky MG, Normanseil DE, Horwitz DA: Depressed cell-mediated immunity in patients with primary intracranial tumors. J Exp Med 136: 1631–1647, 1972.

    Article  PubMed  CAS  Google Scholar 

  49. Brooks WH, Caldwell HD, Mortara RH: Immune responses in patients with gliomas. Surg Neurol 2: 419–423, 1974.

    PubMed  CAS  Google Scholar 

  50. Young HF, Sakalas R, Kaplan AM: Inhibition of cell-mediated immunity in patients with brain tumors. Surg Neurol 5: 19–23, 1976.

    PubMed  CAS  Google Scholar 

  51. Brooks WH, Latta RB, Mahaley MS, Roszman TL, Dudka L, Skaggs C: Immunobiology of primary intracranial tumors. Part 5: Correlation of a lymphocyte index and clinical status. J Neurosurg 54: 331–337, 1981.

    Article  PubMed  CAS  Google Scholar 

  52. Levy NL: Specificity of lymphocyte-mediated cytotoxicity in patients with primary intracranial tumors. J Immunol 121: 903–915, 1978.

    PubMed  CAS  Google Scholar 

  53. Takasugi M, Mickey MR, Terasaki PI: Studies on specificity of cell-mediated immunity to human tumors. J Natl Cancer Inst 53: 1527–1538, 1974.

    PubMed  CAS  Google Scholar 

  54. Herberman RB, Oldham RK: Problems associated with study of cell-mediated immunity to human tumors by microcytotoxicity assays. J Natl Cancer Inst 55: 749–753, 1975.

    PubMed  CAS  Google Scholar 

  55. Gately MK, Glaser M, Mettetal RW Jr., Dick SJ, Kornblith PL: The generation in vitro of lymphocytes cytotoxic for allogeneic human glioma cells: Requirement for third-party stimulator lymphocytes. Fed Proc 40:1041, 1981 (Abs).

    Google Scholar 

  56. Rosenblum ML, Hoshino T, Levin VA, Wilson CB: Planning of brain tumor therapy based on laboratory investigations — sequential BCNU-5-FU treatment of malignant gliomas. Scientific Manuscripts AANS, 31–32, 1981.

    Google Scholar 

  57. Wilson CB, Boldrey EB, Enot KJ: 1,3-bis (2-chloroethyl)-1-nitrosourea, (NSC-409962) in the treatment of brain tumors. Cancer Chemother Rep 54: 273–281, 1970.

    PubMed  CAS  Google Scholar 

  58. Young RC, Walker MD, Canellos GP, Schein PS, Chabner BA, DeVita VT: Initial clinical trials with methyl-CCNU l-(2-chloroethyl)-3-(4-methyl cyclohexyl) 1-nitrosourea (MeCCNU). Cancer 31: 1164–1169, 1973.

    Article  PubMed  CAS  Google Scholar 

  59. Hoogstraten B, Gottlieb JA, Caoili E, Tucker WG, Talley RW, Haut A: CCNU (1-[2-chlo-roethyl]-3-cyclohexyl-1-nitrosourea, (NSC-79037) in the treatment of cancer. Phase II study. Cancer 32: 38–43, 1973.

    Article  PubMed  CAS  Google Scholar 

  60. Wasserman TH, Slavik M, Carter SK: Review of CCNU in clinical cancer chemotherapy. Cancer Treat Rev 1: 131–151, 1974.

    Article  Google Scholar 

  61. Walsh JM, Cassidy JR, Frie E III, Kornblith PL, Welch K: Recent advances in the treatment of primary brain tumors. A Seminar. Arch Surg 110: 696–702, 1975.

    Google Scholar 

  62. Reagan TJ, Bisel HF, Childs DS, Layton DD, Rhoton AL, Taylor WF: Controlled study of CCNU and radiation therapy in malignant astrocytoma. J Neurosurg 44: 186–190, 1976.

    Article  PubMed  CAS  Google Scholar 

  63. EORTC Brain Tumor Group: Effect of BCNU on survival, rate of objective remission and duration of free interval in patients with malignant brain glioma — first evaluation. Europ J Cancer 12: 41–45, 1976.

    Article  Google Scholar 

  64. Walker MD, Green SB, Byar DP, Alexander E, Batzdorf U, Brooks WH, Hunt WE, MacCarty CS, Mahaley MS, Mealey J, Owens G, Ransohoff J, Robertson JT, Shapiro WR, Smith KR, Wilson CB, Strike TA: Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 303: 1323–1329, 1980.

    Article  PubMed  CAS  Google Scholar 

  65. Sjogren HO, Hellstrom I, Bansal SC, Hellstrom KE: Suggestive evidence that blocking antibodies of tumor-bearing individuals may be antigen-antibody complexes. Proc Natl Acad Sei USA. 68: 1372, 1971.

    Article  CAS  Google Scholar 

  66. Rosenblum ML, Vasquez DA, Hoshino T, Wilson CB: Development of a clonogenic cell assay for human brain tumors. Cancer 41: 2305–2314, 1978.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Paul L. Kornblith
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Barry H. Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Maurice K. Gately
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. National Institutes of Health, NINCDS, STP, Federal 8A-08, Bethesda, MD, 20205, USA

    Michael D. Walker M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Martinus Nijhoff Publishers, Boston/The Hague/Dordrecht/Lancaster

About this chapter

Cite this chapter

Kornblith, P.L., Smith, B.H., Gately, M.K. (1983). Tumor Cell and Host Response Parameters in Designing Brain Tumor Therapy. In: Walker, M.D. (eds) Oncology of the Nervous System. Cancer Treatment and Research, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3858-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3858-1_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3860-4

  • Online ISBN: 978-1-4613-3858-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation