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Inhibitors of Microtubule Formation

  • Chapter
Adrenal and Endocrine Tumors in Children

Part of the book series: Cancer Treatment and Research ((CTAR,volume 17))

Abstract

A number of diverse chemical agents have been identified which perturb microtubule assembly and disassembly by interacting specifically with microtubule protein. Microtubules are found in all eukaryotic cells and are a major component of the mitotic spindle. Drugs that perturb microtubule polymerization and depolymerization in many cases are potent antimitotic agents with potential in cancer chemotherapy. In this chapter we review the pharmacology of a number of antimicrotubule drugs with emphasis on the mechanisms by which they alter microtubule function. To keep the review tractable, as the list of antimicrotubule agents is large, we confined ourselves primarily to the following drugs: colchicine and its derivatives; podophyllotoxins and nocodazole (competitive inhibitors of colchicine); the vinca alkaloids (e.g. vinblastine and vincristine); the macrolides (e.g., maytansine); taxol; and griseofulvin. These drugs were chosen, in part, because they illustrate different mechanisms of assembly inhibition. Furthermore, most of these drugs have been found to be effective in cancer chemotherapy and many are in clinical use. Our review benefited from a number of excellent earlier reviews (see references [1–4]).

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Authors
  1. Himan Sternlicht
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Editors and Affiliations

  1. Department of Pediatrics, Hematology-Oncology Oklahoma Children’s Memorial Hospital, University of Oklahoma Health Sciences Center, P.O. Box 26307, Oklahoma City, OK, 73126, USA

    G. Bennett Humphrey M.D., Ph.D.

  2. Department M-305, Lilly Research Laboratories, 307 E. McCarty Street, Indianapolis, IN, 46285, USA

    Gerald B. Grindey

  3. Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Box 609, Mayo Memorial Building, Minneapolis, MN, 55455, USA

    Louis P. Dehner

  4. Diabetes Research Hospital, University of Alabama in Birmingham, Room 817 1808 7th Avenue, South Brimingham, AL, 35233, USA

    Ronald T. Acton Ph.D.

  5. Department of Pathology Oklahoma Children’s Memorial Hospital, University of Oklahoma Health Sciences Center, P.O. Box 26307, Oklahoma City, OK, 73126, USA

    Theodore J. Pysher

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© 1983 Martinus Nijhoff Publishers, Boston

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Sternlicht, H. (1983). Inhibitors of Microtubule Formation. In: Humphrey, G.B., Grindey, G.B., Dehner, L.P., Acton, R.T., Pysher, T.J. (eds) Adrenal and Endocrine Tumors in Children. Cancer Treatment and Research, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3891-8_4

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