Summary
Infection of A9 strain of mouse L-cells with the lymphotropic strain of minute virus of mice (MVM(i)), resulted in initial arrest of viral replication and a subsequent establishment of a short term, 150 day long persistent infection. The virus produced by the carrier culture differed from MVM(i) in its ability to replicate lytically in A9 cells and the parallel loss of infectivity to T-lymphocytes. The newly acquired host range was a stable property of the progeny virus, suggesting that it is genetically determined. Restriction endonuclease analysis failed to detect differences between the mutant viral DNA and that of MVM(i), indicating that the host range determining region in the viral genome is small.
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References
Bournguignon, G.J., Tattersall, P. and Ward, D.C. J. Virol. 20: 29–306, 1976.
McMaster, G.K., Beard, P., Ingres, H.D. and Hirt, B. J. Virol. 38: 317–326, 1981.
Bonnard, G.D., Manders, E.K., Campbell, D.A. Jr., Herberman, R.B. and Collins, M.J. J. Exp. Med. 143: 187–205, 1976.
Spalholz, B.A., Bratton, J., Ward, D.C, and Tattersall, P. J. Cell Biochem., in press.
Stein, H.M. and Enders, J.F. Proc. Soc. Exptl. Biol. Med. 109: 495–499, 1962.
Quade, K. Virology 98: 461–465, 1979.
Littlefield, J.W. Nature 203: 1142–1144, 1964.
Shevach, E.J., Stabe, J.D. and Green, I. J. Immunol. 108: 1146–1151, 1972.
Mather, J.P. and Sato, G.H. Exp. Cell Res. 124: 215–221, 1979.
Littlefield, J.W. Science 145: 709–710, 1963.
Tattersall, P. J. Virol. 10: 586–590, 1972.
Tattersall, P. In: Replication of Mammalian Parvoviruses (Eds. D.C. Ward and P. Tattersall) Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., 1978, pp. 131–149.
Lavi, S. and Etkin, S., Carcinogenesis 2: 417–423, 1981.
Youngner, J.S., Dubovi, E.J., Quagliana, D.O., Kelly, M. and Preble, O.T. J. Virol. 19: 90–101, 1976.
Youngner, J.S. and Preble, O.T. Comprehensive Virology 16: 73–135, 1980.
Yoshida, T., Hamaguchi, M., Naruse, H. and Nagai, H. Virology 120: 329–339, 1982.
Holland, J.J., Kennedy, S. Ian T., Semler, B.L., Jones, C.L., Roux, L. and Grabau, E.A. Comprehensive Virology 16: 137–192, 1980.
Huang, A.S. and Baltimore, D. Mature 226: 325–327, 1970.
Ramseur, J.M. and Friedman, R.M. J. Gen. Virol. 37: 523–533, 1977.
Mathews, J.H. and Vorndam, A.V. J. Gen. Virol. 61: 177–186, 1982.
Weinberg, R.A. Ann. Rev. Biochem. 9: 197–226, 1980.
Handa, H., Shiroki, K. and Shimojo, H. Virology 82: 84–92, 1977.
Holland, J.J., Spindler, K., Horodyski, F., Grabau, E., Nichol, S. and Vandepol, S. Science 215: 1577–1585, 1982.
Youssoufian, H., Hammer, S.M., Hirsch, M.S. and Mulder, C. Proc. Natl. Acad. Sci. USA 79: 2207–2210, 1982.
Holland, J.J., Semler, B.L., Jones, C., Perrault, J., Reid, L. and Roux, L. In: ICN-UCLA Symp. Molec. Cell. Biol., Vol. 11 (Eds: J.G. Stevens, G.T. Todaro and C.F. Fox) Academic Press, 1978, pp. 57–73.
Ahmed, R., Canning, W.M., Kauffman, R.S., Sharpe, A.H., Hallum, J.V. and Fields, B.N. Cell 25: 325–332, 1981.
Stewart, C.L., Stuhtmann, H., Jahner, D. and Jaenisch, R. Proc. Natl. Acad. Sci. USA 79: 4098–4102, 1982.
Kruczek, I. and Doerfler, W. The EMB0 Journal 1: 409–414, 1982.
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© 1984 Martinus Nijhoff Publishing, Boston
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Ron, D., Guetta, E., Tal, J. (1984). Host Range Transition of Lymphotropic Minute Virus of Mice During Persistent Infection in L-Cells. In: Kohn, A., Fuchs, P. (eds) Mechanisms of Viral Pathogenesis. Developments in Molecular Virology, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3894-9_9
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DOI: https://doi.org/10.1007/978-1-4613-3894-9_9
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