Abstract
Recently, we have observed that chickens vaccinated with the herpesvirus of turkey (HVT) develop lymphoproliferative lesions (1) and a cell mediated immune response to the Marekfs disease tumor associated surface antigen (MATSA) (2). The purpose of this presentation is to consider these observations in view of the overall mechanism of vaccine protection in Marekfs disease (MD) and to speculate on the possible role MATSA immunity may play in protection. Furthermore, additional data are presented that confirm earlier observations on the presence of MATSA in HVT infected chickens.
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References
Witter, R. L., Sharma, J. M., and Offenbecker, Linda, Avian Dis., 20: 676 (1976).
Sharma, J. M. C Submitted
Purchase, H. G. and Sharma, J. M., Nature, 248: 419 (1974).
Else, R. W., Vet. Rec., 95: 187 (1974).
Powell, P. C., Payne, L. N., Frazier, J. A. and Rennie, M., Nature, 251: 79 (1974).
Witter, R. L., Stephens, E. A., Sharma, J. M. and Nazerian, K., J. Immunol., 115: 177 (1975).
Powell, P. C., Bibl. Haemat., 43: 348 (1976).
Sharma, J. M. and Coulson, B. C., J. Nat. Cancer Inst., (In the press).
Stone, H. A., Technical Bulletin No. 1514. Agricultural Research Service, United States Department of Agriculture, (1975).
Sharma, J. M., Witter, R. L., Burmester, B. R., Inf. and Immun., 8: 715 (1973).
Nazerian, K. and Sharma, J. M., J. Nat. Cancer Inst., 54: 277 (1975).
Akiyama, Y. and Kato, S., Biken J., 17: 105 (1974).
Lee, L. F., Nazerian, K. and Boezi, J. A. in Oncogenesis and Herpesvirus II pp. 199 (de The, Epstein,.) (International Agency for Research on Cancer, 1975 ).
Siegfried, L. M, and Olson, C., J. Nat. Cancer Inst., 48: 791 (1972).
Payne, L. N. and Biggs, P. M., J. Nat. Cancer Inst., 39: 281 (1967).
Herbarman, R. B., Bartram, S., Haskill, J. S., Nunn, M., Holden, H. T. and West, W. H. (Submitted).
Nunn, M. E., Djeu, J. Y., Glaser, M., Lavrin, D. H. and Herberman, R. B., J. Nat. Cancer Inst., 56: 393 (1976).
Payne, L. N. and Rennie, M., J. Nat. Cancer Inst. 51: 1559 (1973).
Nazerian, K., Lee, L. F., and Sharma, J. M. Prog. Med. Virol., 22: 123 (1976).
Schierman, L. W., Theis, G. A. and McBride, R. A., J. Immunol. 116: 1497 (1976).
Purchase, H. G. and Okazaki, W., Avian Dis., 15: 391 (1971).
Kaaden, O. R., Dietzschold, B. and Ueberschar, S., Med. Microbiol., 159: 261 (1974).
Lesnik, F. and Ross, L. J. N., Int. J. Cancer, 16: 153 (1975).
Payne, L. N., Frazier, J. A. and Powell, P. C., Int. Rev. Exp. Pathol., 16: 59 (1976).
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Sharma, J.M. (1977). Role of Tumor Antigen in Vaccine Protection in Marek’s Disease. In: Benedict, A.A. (eds) Avian Immunology. Advances in Experimental Medicine and Biology, vol 88. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4169-7_32
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DOI: https://doi.org/10.1007/978-1-4613-4169-7_32
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