Abstract
The kidney is uniquely involved in the maintenance of body calcium, magnesium, phosphorus, and acid-base balance, both as an endocrine secretory and a target organ. In this light, the kidney reabsorbs calcium and phosphorus more avidly under the stimulus of 25-hydroxycholecalciferol (1–4) while it effects conversion of this compound to the metabolite 1,25-dihydroxycholecalciferol, which is more active on gut (5,6). Controversy exists, however, as to the necessity for parathyroid hormone (PTH) to facilitate the renal actions of 25-hydroxycholecalciferol (1–4,7,8). The present studies were undertaken therefore to examine the affect of 25-hydroxycholecalciferol, henceforth referred to as 25-HCC, on the renal handling of calcium, magnesium and phosphate in the intact and acutely thyroparathyroidectomized dog. Since the absorption of phosphate in the latter preparation is virtually complete, bicarbonate infusion was used to increase its excretion.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Puschett, J.B., Moranz, J., and Kurnick, W.S.: Evidence for a direct action of cholecalciferol and 25-hydroxycholecalciferol on the renal transport of phosphate, sodium and calcium. J. Clin. Invest. 51:373–385, 1972.
Popovtzer, M.M., Robinette, J.B., DeLuca, H.F., and Holick, M. F.: The acute effect of 25-hydroxycholecalciferol on renal handling of phosphorus. Evidence for a parathyroid hormone dependent mechanism. J. Clin. Invest. 53:913–921, 1974.
Sutton, R.A.L., Wong, N.L.M., and Dirks, J.H.: 25 hydroxy vitamin D3 {25(OH)D3}: Enhancement of distal tubular calcium reabsorption in the dog. Am. Soc. Neph,, 1975, p. 8.
Costanzo, L.S., Sheehe, P.R., and Weiner, I.M.: Renal actions of vitamin D in D-deficient rats. Am. J. Physiol. 226:1490–1495, 1974.
Fraser, D.R., and Kodicek, E.: Unique biosynthesis by kidney of a biologically active vitamin D metabolite. Nature (London) 228:764–766, 1970.
Holick, M.F., Schnoes, H.K., DeLuca, H.F., Suda, T., and Cousins, R.J.: Isolation and identification of 1,25-dihy-droxycholecalciferol. A metabolite of vitamin D active in intestine. Biochem. 10(14): 2799–2804, 1971.
Puschett, J.B., Beck, W.S., Jr., Jelonek, A., Fernandez, P.: Study of the renal tubular interactions of thyrocalcitonin, cyclic adenosine 3’, 5’-monophosphate, 25-hydroxycholecalciferol, and calcium ion. J. Clin. Invest. 53:756–767, 1974.
Puschett, J.B., Beck, W.S., Jelonek, A.: Parathyroid hormone and 25 hydroxy vitamin D3: Synergistic and antagonistic effects on renal phosphate transport. Science 190:47 3–475, 1975.
Suki, W.N., Martinez-Maldonado, M., Rouse, D., et al: Effect of expansion of extracellular fluid volume on renal phosphate handling. J. Clin. Invest. 48:1888–1894, 1969.
Mercado, A., Slatopolsky, E., and Klahr, S.: On the mechanism responsible for the phosphaturia of bicarbonate administration. J. Clin. Invest. 56(6)1386–1395, 1975.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Springer Science+Business Media New York
About this chapter
Cite this chapter
Peraino, R.A., Ghaffary, E., Rouse, D., Suki, W.N. (1977). Renal Actions of 25-Hydroxyvitamin D3 . In: Massry, S.G., Ritz, E. (eds) Phosphate Metabolism. Advances in Experimental Medicine and Biology, vol 81. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-4217-5_9
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4217-5_9
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4613-4219-9
Online ISBN: 978-1-4613-4217-5
eBook Packages: Springer Book Archive