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Neural Integration of Thermoregulatory Responses

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Limbic and Autonomic Nervous Systems Research

Abstract

Temperature regulation, along with several other fields, is experiencing a quiet revolution in which the hypothalamus is losing its preeminent position as the major center of integrative control. This chapter considers whether the revolution can succeed or, indeed, if it has already. It examines the historical evidence which led to the hypothalamus being regarded as the only thermostat of the brain. It then discusses the current evidence for altering that view — evidence that other parts of the brain have been shown to be both thermosensitive and able to initiate thermoregulatory responses whether or not the hypothalamus is present.

I thank Drs. Joseph Eisenman, R. D. Luce, and Philip Teitelbaum for their many helpful criticisms of the manuscript.

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References

  • Adair, E. R., and Hardy, J. D., 1971, Posterior hypothalamic thermal stimulation can alter behavioral, but not physiological, temperature regulation. Paper presented at International Congress of Physiology, Munich.

    Google Scholar 

  • Adair, E., and Stitt, J. T., 1971, Behavioral temperature regulation in the squirrel monkey: Effects of midbrain temperature displacements, J. Physiol. (Paris) 63: 191.

    CAS  Google Scholar 

  • Adair, E. R., Casby, J. U., and Stolwijk, J. A. J., 1970, Behavioral temperature regulation in the squirrel monkey: Changes induced by shifts in hypothalamic temperature, J. Comp. Physiol. Psycho.72: 17.

    Article  CAS  Google Scholar 

  • Andersson, B., 1957, Cold defense reactions elicited by electrical stimulation within the septal area of the brain in goats, Acta Physiol. Scand.41: 90.

    Article  PubMed  CAS  Google Scholar 

  • Andersson, B., Grant, R., and Larsson, C., 1956, Central control of heat loss mechanisms in the goat, Acta Physiol. Scand.37: 261.

    Article  PubMed  CAS  Google Scholar 

  • Andersson, B., Gale, C. C., and Sundsten, J. W., 1962, Effects of chronic central cooling on alimentation and thermoregulation, Acta Physiol. Scand.55: 177.

    Article  PubMed  CAS  Google Scholar 

  • Andersson, B., Ekman, L., Gale, C. C., and Sundsten, J. W., 1962a, Blocking of the thyroid response to cold by local warming of the preoptic region, Acta Physiol. Scand.56: 94.

    Article  CAS  Google Scholar 

  • Andersson, B., Ekman, L., Gale, C. C., and Sundsten, J. W., 1962b, Activation of the thyroid gland by cooling of the preoptic area in the goat, Acta Physiol. Scand. 54: 191.

    Article  CAS  Google Scholar 

  • Andersson, B., Gale, C., Hokfelt, B., and Larsson, B., 1965, Acute and chronic effects of preoptic lesions, Acta Physiol. Scand. 65: 45.

    Article  Google Scholar 

  • Baldwin, B. A., and Ingram, D. L., 1967, The effect of heating and cooling the hypothalamus on behavioural thermoregulation in the pig, J. Physiol. (London) 191: 375.

    CAS  Google Scholar 

  • Balinska, H., 1968, The hypothalamic lesions: Effects on appetitive and aversive behavior in rats, Acta Biol. Exptl. (Warsaw) 28: 47.

    CAS  Google Scholar 

  • Bard, P., and Macht, M. B., 1958, The behaviour of chronically decerebrate cats, in The Neurological Basis of Behaviour, CIBA Foundation Symposium, Churchill, London, pp. 55–71.

    Google Scholar 

  • Bard, P., Woods, J. W., and Bleier, R., 1970, The effects of cooling, heating and pyrogen on chronically decerebrate cats, in Physiological and Behavioral Temperature Regulation, J. D. Hardy, A. P. Gagge, and J. A. J. Stolwijk, eds., Thomas, Springfield, Illinois, pp. 519–545.

    Google Scholar 

  • Barker, J. L., and Carpenter, D. O., 1970, Thermosensitivity of neurons in the sensorimotor cortex of the cat, Science, 169: 597.

    Article  PubMed  CAS  Google Scholar 

  • Bazett, H. C., and Penfield, W. G., 1922, A study of the Sherrington decerebrate animal in the chronic as well as the acute condition, Brain. 45: 185.

    Article  Google Scholar 

  • Beaton, L. E., McKinley, W. A., Berry, C. M., and Ranson, S. W., 1941, Localization of cerebral center activating heat-loss mechanisms in monkeys, J. Neurophysiol.4: 478.

    Google Scholar 

  • Benzinger, T. H., 1970, Peripheral cold reception and central warm reception, sensory mechanisms of behavioral and autonomic homeostasis, in Physiological and Behavioral Temperature Regulation, J. D. Hardy, A. P. Gagge, and J. A. J. Stolwijk, eds., Thomas, Springfield, Illinois, pp. 831–855.

    Google Scholar 

  • Birzis, L., and Hemingway, A., 1956, Descending brain stem connections controlling shivering in cat, J. Neurophysiol. 19:37.

    PubMed  CAS  Google Scholar 

  • Birzis, L., and Hemingway, A., 1957, Efferent brain discharge during shivering, J. Neurophysiol. 20: 156.

    PubMed  CAS  Google Scholar 

  • Blass, E. M., 1969, Thermoregulatory adjustments in rats after removal of the frontal poles of the brain. J. Comp. Physiol. Psycho.69: 83.

    Article  CAS  Google Scholar 

  • Blass, E. M., 1971, Effects of frontal-pole-ablation on temperature regulation in the rat, J. Comp. Physiol. Psycho!. 74: 233.

    Article  CAS  Google Scholar 

  • Bligh, J., 1966, The thermosensitivity of the hypothalamus and thermoregulation in mammals, Biol. Rev. 41: 317.

    CAS  Google Scholar 

  • Bond, D. D., Randt, C. T., Bidder, T. G., and Rowland, V., 1957, Posterior septal, fornical, and anterior thalamic lesions in the cat, AMA Arch. Neurol. Psychiat. 78: 143.

    CAS  Google Scholar 

  • Bures, J., Buresova, O., Fifkova, E., Olds, J., Olds, M. E., and Travis, R. P., 1961, Spreading depression and subcortical drive centers, Physiol. Bohemoslay. 10: 321.

    Google Scholar 

  • Buresova, O., 1957, Disturbances in thermoregulation and metabolism as a result of prolonged EEG depression, (in Russian), Physiol. Bohemoslov.6: 369.

    Google Scholar 

  • Cabanac, M., 1970, Interaction of cold and warm temperature signals in the brain stem, in Physiological and Behavioral Temperature Regulation, J. D. Hardy, A. P. Gagge, and J. A. J. Stolwijk, eds., Thomas, Springfield, Illinois, pp. 549–561.

    Google Scholar 

  • Cabanac, M., 1972, Thermoregulatory behavior, in Essays on Temperature Regulation, J. Bligh and R. Moore, eds., North Holland, Amsterdam, pp. 19–36.

    Google Scholar 

  • Cabanac, M., and Hardy, J. D., 1968, Spread of neuron activity from sites of local heating and cooling of the brainstem, Proc. XXIV Intrntl Cong. Physiol. Sci.7: 70.

    Google Scholar 

  • Cabanac, M., and Hardy, J. D., 1969, Réponses unitaires et thermorégulatrices lors de réchauffements et refroidissements localisés de la région préoptique et du mésencéphale chez le lapin, J. Physiol. (Paris) 61: 331.

    CAS  Google Scholar 

  • Calvert, D. T., Clough, D. P. Findlay, J. D., and Thompson, G. E., 1972, Hypothalamic cooling, heat production and plasma lipids in the ox, Life Sci. 11: 223.

    Article  CAS  Google Scholar 

  • Carlisle, H. J., 1966, Behavioural significance of hypothalamic temperature-sensitive cells, Nature209: 1324.

    Article  PubMed  CAS  Google Scholar 

  • Carlisle, H. J., 1969, The effects of preoptic and anterior hypothalamic lesions on behavioral thermoregulation in the cold, J. Comp. Physiol. Psycho.69: 391.

    Article  CAS  Google Scholar 

  • Chai, C. Y., and Lin, M. T., 1972, Effects of heating and cooling the spinal cord and medulla oblongata on thermoregulation in monkeys, J. Physiol. (London) 225: 297.

    CAS  Google Scholar 

  • Chai, C. Y., and Wang, S. C., 1970, Cardiovascular and respiratory responses to cooling of the medulla oblongata of the cat, Proc. Soc. Exp. Biol. Med.134: 763.

    PubMed  CAS  Google Scholar 

  • Chai, C. Y., Mu, J. Y., and Brobeck, J. R., 1965, Cardiovascular and respiratory responses from local heating of medulla oblongata, Am. J. Physiol.209: 301.

    PubMed  CAS  Google Scholar 

  • Chambers, W. W., Koenig, H., Koenig, R., and Windle, W. F., 1949, Site of action in the central nervous system of a bacterial pyrogen, Am. J. Physiol.159: 209.

    PubMed  CAS  Google Scholar 

  • Chambers, W. W., Seigel, M. S., Liu, J. C., and Liu, C. N., 1974, Thermoregulatory responses of decerebrate and spinal cats, Exptl. Neurol.42: 282.

    Article  CAS  Google Scholar 

  • Clark, G., 1940, Temperature regulation in chronic cervical cats, Am. J. Physiol.130: 712.

    Google Scholar 

  • Clark, G., 1960, Heat dissipation function following experimental anterior hypothalamic lesions in cats, in Neural Aspects of Temperature Regulation, E. G. Viereck, ed., Arctic Biology and Medicine, Transactions of the First Symposium, pp. 149–192.

    Google Scholar 

  • Clark, G., Magoun, H. W., and Ranson, S. W., 1939a, Hypothalamic regulation of body temperature, J. Neurophysiol.2: 61.

    Google Scholar 

  • Clark, G., Magoun, H. W. and Ranson, S. W., 1939b, Temperature regulation in cats with thalamic lesions, J. Neurophysiol.2: 202.

    Google Scholar 

  • Connor, J. D., and Crawford, I. L., 1969, Hyperthermia in midpontine lesioned cats, Brain Res. 15:590.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, K. E., Cranston, W. I., and Honour, A. J., 1967, Observations on the site and mode of action of pyrogens in the rabbit brain, J. Physiol. (London) 191: 325.

    CAS  Google Scholar 

  • Corbit, J. D., 1969, Behavioral regulation of hypothalamic temperature, Science. 166: 256.

    Article  PubMed  CAS  Google Scholar 

  • Corbit, J. D., 1970, Behavioral regulation of body temperature, in Physiological and Behavioral Temperature Regulation, J. D. Hardy, A. P. Gagge, and J. A. J. Stolwijk, eds., Thomas, Springfield, Illinois, pp. 777–801.

    Google Scholar 

  • Cytawa, J., and Teitelbaum, P., 1967, Spreading depression and recovery of subcortical functions, Acta Biol. Exptl. (Warsaw) 27: 345.

    CAS  Google Scholar 

  • Delgado, J., and Livingston, R., 1948, Some respiratory, vascular and thermal responses to stimulation of orbital surface of frontal lobe, J. Neurophysiol.11: 39.

    PubMed  CAS  Google Scholar 

  • Edinger, H. M., and Eisenman, J. S., 1970, Thermosensitive neurons in tuberai and posterior hypothalamus of cats, Am. J. Physiol.219: 1098.

    PubMed  CAS  Google Scholar 

  • Edwards, D. A., and Roberts, R. L., 1972, Olfactory bulb removal produces a selective deficit in behavioral thermoregulation, Physiol. Behay.9: 747.

    Article  CAS  Google Scholar 

  • Eisenman, J. S., and Jackson, D. C., 1967, Thermal response patterns of septal and preoptic neurons in cats, Exptl. Neurol.19: 33.

    Article  CAS  Google Scholar 

  • Feldberg, W., and Myers, R. D., 1963, A new concept of temperature regulation by amines in the hypothalamus, Nature. 200: 1325.

    Article  PubMed  CAS  Google Scholar 

  • Finger, S., and Maickel, R. P., 1970, Lesions of cortical and thalamic somatosensory areas and body temperature maintenance, Brain Res. 21: 284.

    Article  PubMed  CAS  Google Scholar 

  • Freeman, W. J., and Davis, D. D., 1959, Effects on cats of conductive hypothalamic cooling, Am. J. Physiol.197: 145.

    PubMed  CAS  Google Scholar 

  • Fusco, M. M., Hardy, J. D., and Hammel, H. T., 1961, Interaction of central and peripheral factors in physiological temperature regulation, Am. J. Physiol.200: 572.

    PubMed  CAS  Google Scholar 

  • Gale, C. C., and Jobin, M., 1967, Further studies on CNS-endocrine responses to hypothalamic cooling in unanesthetized baboons, Fed. Proc.26: 255.

    Google Scholar 

  • Gale, C. C., Mathews, M., and Young, J., 1970, Behavioral thermoregulatory responses to hypothalamic cooling and warming in baboons, Physiol. Behay.5: 1.

    Article  CAS  Google Scholar 

  • Guieu, J. D., and Hardy, J. D., 1970a, Effects of heating and cooling of the spinal cord on preoptic unit activity, J. Appt. Physiol.29: 675.

    CAS  Google Scholar 

  • Guieu, J. D., and Hardy, J. D., 1970b, Effects of preoptic and spinal cord temperature in control of thermal polypnea, J. Appt. Physiol.28: 540.

    CAS  Google Scholar 

  • Guttmann, L., Silver, J., and Wyndham, C. H., 1958, Thermoregulation in spinal man, J. Physiol. (London) 142: 406.

    CAS  Google Scholar 

  • Hainsworth, R., and Stricker, E., 1970, Salivary cooling by rats in the heat, in Physiological and Behavioral Temperature Regulation, J. D. Hardy, A. A. J. Gagge, and J. P. Stolwijk, eds., Thomas, Springfield, Illinois, pp. 611–626.

    Google Scholar 

  • Hamilton, C. L., 1967, Food and temperature in Handbook of Physiology: Alimentary Canal, sect. 6, vol. 1, Am. Physiol. Soc., Washington, D.C., pp. 303–318.

    Google Scholar 

  • Hamilton, C. L., and Brobeck, J. R., 1964, Food intake and temperature regulation in rats with rostral hypothalamic lesions, Am. J. Physiol.207: 291.

    PubMed  CAS  Google Scholar 

  • Hamilton, C. L., and Brobeck, J. R., 1966, Food intake and activity of rats with rostral hypothalamic lesions, Proc. Soc. Exptl. Biol. Med. 122:270.

    CAS  Google Scholar 

  • Hammel, H. T., Hardy, J. D., and Fusco, M. M., 1960, Thermoregulatory responses to hypothalamic cooling in unanesthetized dogs, Am. J. Physiol. 198:481.

    PubMed  CAS  Google Scholar 

  • Han, P. W., and Brobeck, J. R., 1961, Deficits of temperature regulation in rats with hypothalamic lesions, Am. J. Physiol. 200:707.

    PubMed  CAS  Google Scholar 

  • Hannon, J. P., 1963, Cellular mechanisms in the metabolic acclimatization to cold, in Temperature: Its Measurement and Control in Science and Industry, Vol. 3, J. D. Hardy, ed., Reinhold, New York, pp. 469–484.

    Google Scholar 

  • Hardy, J. D., 1961, Physiology of temperature regulation, Physiol. Rev.41: 521.

    PubMed  CAS  Google Scholar 

  • Hardy, J. D., 1969, Thermoregulatory responses to temperature changes in the midbrain of the rabbit, Fed. Proc. 28:713.

    Google Scholar 

  • Hardy, J. D., Helton, R. F., and Sutherland, K., 1964, Temperature-sensitive neurons in the dog’s hypothalamus, J. Physiol. (London) 175: 242.

    CAS  Google Scholar 

  • Hayward, J. N., and Baker, M. A., 1968, Diuretic and thermoregulatory responses to preoptic cooling in the monkey, Am. J. Physiol.214: 843.

    PubMed  CAS  Google Scholar 

  • Hellon, R. F., 1970, Hypothalamic neurons responding to changes in hypothalamic and ambient temperatures, in Physiological and Behavioral Temperature Regulation, J. D. Hardy, A. P. Gagge, and J. A. J. Stolwijk, eds., Thomas, Springfield, Illinois, pp. 463–471.

    Google Scholar 

  • Hellon, R. F., 1972, Central transmitters and thermoregulation, in Essays in Temperature Regulation, J. Bligh and R. Moore, eds., North Holland, Amsterdam, pp. 71–85.

    Google Scholar 

  • Hemingway, A., 1963, Shivering, Physiol. Rev. 43: 397.

    PubMed  CAS  Google Scholar 

  • Hemingway, A., and Stuart, D. G., 1963, Shivering in man and animals, in Temperature: Its Measurement and Control in Science and Industry, Vol. 3. J. D. Hardy, ed., Reinhold, New York, pp. 407–427.

    Google Scholar 

  • Holmes, R. L., Newman, P. P., and Wolstencroft, J. H., 1960, A heat sensitive region in the medulla, J. Physiol. (London) 152: 93.

    CAS  Google Scholar 

  • Ingram, W. R., 1960, Central autonomic mechanisms, in Handbook of Physiology: Neurophysiology, sect. 1, vol. 2, Am. Physiol. Soc., Washington, D.C., pp. 951–978.

    Google Scholar 

  • Isenschmid, R., and Schnitzler, W., 1914, Beitrag zur Lokalisation des der Wärmeregulation vorstehenden Zentral-apparates im Zwischenhirn, Arch. Exp. Path.76: 202.

    Article  Google Scholar 

  • Jessen, C., and Ludwig, O., 1971, Spinal cord and hypothalamus as core sensors of temperature in the conscious dog. II. Addition of signals, Pflug. Arch.324: 205.

    Article  CAS  Google Scholar 

  • Jessen, C., and Mayer, E. T., 1971, Spinal cord and hypothalamus as core sensors of temperature in the conscious dog. I. Equivalence of responses, Pflug. Arch.324: 189.

    Article  CAS  Google Scholar 

  • Jessen, C., and Simon, E., 1971, Spinal cord and hypothalamus as core sensors of temperature in the conscious dog. III. Identity of functions, Pflug. Arch.324: 217.

    Article  CAS  Google Scholar 

  • Karli, P., and Vergnes, M., 1964, Dissociation expérimentale du comportement d’agression interspécifique Rat-Souris et du comportement alimentaire. Comp. Ren. Soc. Biol.158: 650.

    CAS  Google Scholar 

  • Keller, A. D., 1932, Autonomic discharges elicited by physiological stimuli in midbrain preparations, Am. J. Physiol.100: 576.

    Google Scholar 

  • Keller, A. D., 1933, Observations of the localization in the brain-stem of mechanisms controlling body temperature, Am. J. Med. Sci.185: 746.

    Article  Google Scholar 

  • Keller, A. D., 1938, Separation in the brain stem of the mechanisms of heat loss from those of heat production, J. Neurophysiol.1: 543.

    Google Scholar 

  • Keller, A. D., 1963, Temperature regulation disturbances in dogs following hypothalamic ablations, in Temperature: Its Measurement and Control in Science and Industry, Vol. 3, J. D. Hardy, ed., Reinhold, New York, pp. 571–584.

    Google Scholar 

  • Keller, A. D., and McClaskey, E. B., 1964, Localization, by the brain slicing method, of the level or levels of the cephalic brainstem upon which effective heat dissipation is dependent, Am. J. Phys. Med.43: 181.

    PubMed  CAS  Google Scholar 

  • Koizumi, K., Brooks, C. McC., and Ushiyama, J., 1959, Hypothermia and reaction patterns of the nervous system, Ann. N.Y. Acad. Sci.80: 449.

    Article  PubMed  CAS  Google Scholar 

  • Kosaka, M., and Simon, E., 1968a, Kaltetremor wacher, chronisch spinalisierter Kaninchen im Vergleich zum Kaltezittern intakter Tiere, Pflug. Arch.302: 333.

    Article  CAS  Google Scholar 

  • Kosaka, M., and Simon, E., 1968b, Der zentralnervose spinale Mechanismus des Kaltezitterns, Pflug. Arch.302: 357.

    Article  CAS  Google Scholar 

  • Kosaka, M., Simon, E., and Thauer, R., 1967, Shivering in intact and spinal rabbits during spinal cord cooling, Experientia. 23: 385.

    Article  PubMed  CAS  Google Scholar 

  • Kosaka, M., Simon, E., Thauer, R., and Walther, O., 1969, Effect of thermal stimulation of spinal cord on respiratory and cortical activity, Am. J. Physiol.217: 858.

    PubMed  CAS  Google Scholar 

  • Lilienthal, J. L., and Otenasek, F. J., 1937, Decorticate polypneic panting in the cat, Bull. Johns Hopkins Hosp.61: 101.

    Google Scholar 

  • Lipton, J. M., 1968, Effects of preoptic lesions on heat-escape responding and colonic temperature in the rat, Physiol. Behay., 3: 165.

    Article  Google Scholar 

  • Lipton, J. M., 1971, Thermal stimulation of the medulla alters behavioral temperature regulation, Brain Res. 26: 439.

    PubMed  CAS  Google Scholar 

  • Lipton, J. M., 1973, Thermosensitivity of medulla oblongata in control of body temperature, Am. J. Physiol.224: 890.

    PubMed  CAS  Google Scholar 

  • Lomax, P., 1970, Drugs and body temperature, Int. Rev. Neurobiol.12: 1.

    Article  PubMed  CAS  Google Scholar 

  • Magoun, H. W., Harrison, F., Brobeck, J. R., and Ranson, S. W., 1938, Activation of heat loss mechanisms by local heating of the brain, J. Neurophysiol.1: 101.

    Google Scholar 

  • McCrum, W. R., 1953, A study of diencephalic mechanisms in temperature regulation, J. Comp. Neurol.98: 233.

    Article  PubMed  CAS  Google Scholar 

  • McGinty, D. J., 1969, Somnolence, recovery and hyposomnia following ventromedial diencephalic lesions in the rat, Electroenceph. Clin. Neurophysiol.26: 70.

    Article  PubMed  CAS  Google Scholar 

  • Meurer, K. A., Jessen, C., and Iriki, M., 1967, Kaltezittern wahrend isolierter Kuhlung des Ruckenmarks nach Durchschneidung der Hinterwurzeln, Pflug. Arch.293: 236.

    Article  CAS  Google Scholar 

  • Meyer, H. H., 1913, Theorie des Fiebers und seiner Behandlung, Verhandl. Dtsch. Bes. Inn. Med.30: 15.

    Google Scholar 

  • Morishima, M. S., and Gale, C. C., 1972, Relationship of blood pressure and heart rate to body temperature in baboons, Am. J. Physiol.223: 387.

    PubMed  CAS  Google Scholar 

  • Mountcastle, V. B., 1956, The reflex activity of the spinal cord, in Medical Physiology, P. Bard, ed., Mosby, St. Louis, pp. 1014–1052.

    Google Scholar 

  • Murgatroyd, D., and Hardy, J. D., 1970, Central and peripheral temperatures in behavioral thermoregulation of the rat, in Physiological and Behavioral Temperature Regulation, J. D. Hardy, A. P. Gagge, and J. A. J. Stolwijk, eds., Thomas, Springfield, Illinois, pp. 874–891.

    Google Scholar 

  • Myers, R. D., 1969, Temperature regulation: neurochemical systems in the hypothalamus, in The Hypothalamus, W. Haymaker, E. Anderson, and W. J. H. Nauta, eds., Thomas, Springfield, Illinois, pp. 506–523.

    Google Scholar 

  • Myers, R. D., 1970, The role of hypothalamic transmitter factors in the control of body temperature, in Physiological and Behavioral Temperature Regulation, J. D. Hardy, A. P. Gagge, and J. A. J. Stolwijk, eds., Thomas, Springfield, Illinois, pp. 648–666.

    Google Scholar 

  • Myers, R. D., and Veale, W. L., 1970, Body temperature: possible ionic mechanism in the hypothalamus controlling the set point, Science 170:95.

    Article  PubMed  CAS  Google Scholar 

  • Myers, R. D., and Yaksh, T. L., 1971, Thermoregulation around a new set-point established in the monkey by altering the ratio of sodium to calcium ions within the hypothalamus, J. Physiol. (London) 218: 609.

    CAS  Google Scholar 

  • Nakayama, T., and Hardy, J. D., 1969, Unit responses in the rabbit’s brain stem to changes in brain and cutaneous temperature, J. Appl. Physiol.27: 848.

    PubMed  CAS  Google Scholar 

  • Nakayama, T., Hammel, H. T., Hardy, J. D., and Eisenman, J. S., 1963, Thermal stimulation of electrical activity of single units of the preoptic region, Am. J. Physiol.204: 1122.

    Google Scholar 

  • Ott, I., 1884, The relation of the nervous system to the temperature of the body, J. Nerv. Men. Dis.11: 141.

    Article  Google Scholar 

  • Pinkston, J. O., Bard, P., and Rioch, D. McK., 1934, The responses to changes in environ- mental temperature after removal of portions of the forebrain, Am. J. Physiol.109: 515.

    Google Scholar 

  • Randall, W. C., 1963, Sweating and its neural control, in Temperature: Its Measurement and Control in Science and Industry, Vol. 3, J. D. Hardy, ed., Reinhold, New York, pp. 275–286.

    Google Scholar 

  • Ranson, S. W., 1940, Regulation of body temperature, Proc. Soc. Assoc. Res. Nerv. Men. Dis.20: 342.

    Google Scholar 

  • Ranson, S. W., and Clark, S. L., 1959, The Anatomy of the Nervous System, 10th ed., Saunders, Philadelphia.

    Google Scholar 

  • Ranson, S. W., and Magoun, H. W., 1939, The hypothalamus, Ergebn. Physiol.41: 56.

    Google Scholar 

  • Richet, C., 1884, La fièvre traumatique nerveuse et l’influence des lésions du cerveau sur la température générale, Comp. Rend. Soc. Biol.1: 189.

    Google Scholar 

  • Roberts, W., 1970, Hypothalamic mechanisms for motivational and species-typical behavior, in The Neural Control of Behavior, R. E. Whalen, R. F. Thompson, M. Verzeano, and N. M. Weinberger, eds., Academic Press, New York, pp. 175–206.

    Google Scholar 

  • Roberts, W. W., and Mooney, R. D., 1974, Brain areas controlling thermoregulatory grooming, prone extension, locomotion and tail vasodilatation in rat, J. Comp. Physiol. Psycho.86: 470.

    Article  CAS  Google Scholar 

  • Rosendorff, C., and Mooney, J. J., 1971, Central nervous system sites of action of a purified leucocytic pyrogen, Am. J. Physiol., 220: 597.

    PubMed  CAS  Google Scholar 

  • Ruch, T. C., 1960, Central control of the bladder, in Handbook of Physiology: Neurophysiology, sect. 1, vol. 2, Am. Physiol. Soc., Washington, D.C., pp. 1207–1223.

    Google Scholar 

  • Rudiger, W., and Seyer, G., 1965, On the lateralization of cortico-hypothalamic relations as revealed by thermosensitive behavior in the rat, Physiol. Bohemoslov.14: 515.

    PubMed  CAS  Google Scholar 

  • Rudiger, W., and Seyer, G., 1968, Thermosensitive bar-pressing behavior of the rat with unilateral lesion in the hypothalamus and during cortical spreading depression, Acta Biol. Exptl. (Warsaw) 28: 375.

    CAS  Google Scholar 

  • Satinoff, E., 1964, Behavioral thermoregulation in response to local cooling of the rat brain, Am. J. Physiol.206: 1389.

    PubMed  CAS  Google Scholar 

  • Satinoff, E., 1967, Aberrations of regulation in ground squirrels following hypothalamic lesions, Am. J. Physiol.212: 1215.

    PubMed  CAS  Google Scholar 

  • Satinoff, E., and Rutstein, J., 1970, Behavioral thermoregulation in rats with anterior hypothalamic lesions, J. Comp. Physiol. Psycho.71: 77.

    Article  CAS  Google Scholar 

  • Satinoff, E., and Shan, S. Y. Y., 1971, Loss of behavioral thermoregulation after lateral hypothalamic lesions in rats, J. Comp. Physiol. Psycho.77: 302.

    Article  CAS  Google Scholar 

  • Seckendorf, R., and Randall, W. C., 1961, Thermal reflex sweating in normal and paraplegic man, J. Appl. Physiol.16: 796.

    Google Scholar 

  • Sherrington, C. S., 1924, Notes on temperature after spinal transection, with some observations on shivering, J. Physiol. (London) 58: 405.

    CAS  Google Scholar 

  • Simon, E., Klussman, F. W., Rautenberg, W., and Kosaka, M., 1966, Kaltezittern bei narkotisierten spinalen Hunden, Pflug. Arch.291: 187.

    Article  CAS  Google Scholar 

  • Squires, R. D., and Jacobson, F. H., 1968, Chronic deficits of temperature regulation produced in cats by preoptic lesions, Am. J. Physiol.214: 549.

    PubMed  CAS  Google Scholar 

  • Stein, L., 1964, Reciprocal action of reward and punishment mechanisms, in The Role of Pleasure in Behavior, R. G. Heath, ed., Harper and Row, New York, pp. 113–139.

    Google Scholar 

  • Stuart, D. G., Kawamura, Y., and Hemingway, A., 1961, Activation and suppression of shivering during septal and hypothalamic stimulation, Exptl. Neurol.4: 485.

    Article  CAS  Google Scholar 

  • Stuart, D. G., Kawamura, Y., Hemingway, A., and Price, W. M., 1962, Effects of septal and hypothalamic lesions on shivering, Exptl. Neurol.5: 335.

    Article  CAS  Google Scholar 

  • Sundsten, J. W., 1967, Effects of steady and cyclic hypothalamic thermal stimulation in unanesthetized cats, J. Appl. Physiol.22: 1129.

    Google Scholar 

  • Tabatabai, M., 1972a, Respiratory and cardiovascular responses resulting from heating the medulla oblongata in cats, Am. J. Physiol.222: 1558.

    CAS  Google Scholar 

  • Tabatabai, M., 1972b, Respiratory and cardiovascular responses resulting from cooling the medulla oblongata in cats, Am. J. Physiol.223: 8.

    CAS  Google Scholar 

  • Teague, R. S., and Ranson, S. W., 1936, The role of the anterior hypothalamus in temperature regulation, Am. J. Physiol.117: 562.

    Google Scholar 

  • Teitelbaum, P., and Epstein, A. N., 1962, The lateral hypothalamic syndrome: Recovery of feeding and drinking after lateral hypothalamic lesions, Psycho!. Rev.69: 74.

    Article  CAS  Google Scholar 

  • Thauer, R., 1935, Warmeregulation and Fieberfahigkeit nach operativen Eingriffen am Nervensystem homoiothermer Saugetiere, Pflug. Arch.236: 102.

    Article  Google Scholar 

  • Thauer, R., 1970, Thermosensitivity of the spinal cord, in Physiological and Behavioral Temperature Regulation, J. D. Hardy, A. P. Gagge, and J. A. J. Stolwijk, eds., Thomas, Springfield, Illinois, pp. 472–492.

    Google Scholar 

  • Thompson, G. E., and Stevenson, J. A. F., 1965, The temperature response of the male rat to treadmill exercise, and the effect of anterior hypothalamic lesions, Canad. J. Physiol. Pharm.43: 279.

    Article  PubMed  CAS  Google Scholar 

  • Toth, D., 1973, Temperature regulation and salivation following preoptic lesions in the rat, J. Comp. Physiol. Psycho.82: 480.

    Article  CAS  Google Scholar 

  • Villablanca, J., and Myers, R. D., 1965, Fever produced by microinjection of typhoid vaccine into hypothalamus of cats, Am. J. Physiol.208: 703.

    PubMed  CAS  Google Scholar 

  • Wampler, R. S., 1970, Changes in sleep and arousal accompanying the lateral hypothalamic syndrome in rats, Ph.D. thesis, University of Pennsylvania.

    Google Scholar 

  • Weiss, B., and Laties, V. G., 1961, Behavioral thermoregulation, Science. 133: 1338.

    Article  PubMed  CAS  Google Scholar 

  • Wit, A., and Wang, S. C., 1968, Temperature-sensitive neurons in preoptic/anterior hypothalamic region: effects of increasing ambient temperature, Am. J. Physiol. 215: 1151.

    PubMed  CAS  Google Scholar 

  • Woods, J. W., 1964, Behavior of chronic decerebrate rats, J. Neurophysiol.27: 635.

    PubMed  CAS  Google Scholar 

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  1. Departments of Psychology and Physiology, University of Illinois, Champaign, Illinois, USA

    Evelyn Satinoff

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© 1974 Plenum Press, New York

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Satinoff, E. (1974). Neural Integration of Thermoregulatory Responses. In: Limbic and Autonomic Nervous Systems Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4407-0_2

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  • DOI: https://doi.org/10.1007/978-1-4613-4407-0_2

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