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HIV: Antiviral Chemotherapy

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Concepts in Viral Pathogenesis III

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Abstract

The term retrovirus is used to denote a class of animal and human viruses that employ a special DNA polymerase (reverse transcriptase) to catalyze the conversion of genomic RNA to DNA in the process of viral replication. These viruses are interesting in that a crucial step in their replication is the reverse transcription of viral RNA to produce linear, double-stranded (minus strand and plus strand) proviral DNA. In this process the termini of the RNA genome are duplicated to yield structures in the DNA called long-terminal repeats (LTRs). The viral genome is expressed from proviral DNA (the minus strand of DNA), which has enhancer/promoter and polyadenylation signals in the LTRs.

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Authors
  1. Samuel Broder
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Editor information

Editors and Affiliations

  1. Laboratory of Oral Medicine, National Institute of Dental Research, NIH, 20892, Bethesda, Maryland, USA

    Abner Louis Notkins M.D.

  2. Department of Immunology, Scripps Clinic and Research Foundation, 92037, La Jolla, California, USA

    Michael B. A. Oldstone M.D.

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© 1989 Springer-Verlag New York Inc.

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Broder, S. (1989). HIV: Antiviral Chemotherapy. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis III. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8890-6_40

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  • DOI: https://doi.org/10.1007/978-1-4613-8890-6_40

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8892-0

  • Online ISBN: 978-1-4613-8890-6

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