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Use of Biologics to Treat Partial ACL Tears

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The ACL Handbook

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Abstract

The completely torn ACL is both biologically challenged (due to the lack of provisional scaffold formation) and mechanically challenged (due to the difficulty in suturing fibrous tissue ends together). To help decouple the challenges and allow us to first focus on the biologic problem, we needed an in vivo partial ACL tear model. One such model was developed in collaboration with Kurt Spindler at Vanderbilt University. In this model, the central fibers of the ACL are cut, but the fibers on either side of the defect are left intact, thus providing optimal mechanical stability of the defect. Using this model, we were able to demonstrate that the use of a collagen-platelet composite could stimulate biologic and functional healing of a partial ACL defect. The next chapter will then add in the mechanical challenges of a complete ACL tear.

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Acknowledgement

Research reported in this chapter was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number RO1-AR054099. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, Division of Sports Medicine, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA

    Martha M. Murray MD

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  1. Martha M. Murray MD
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Correspondence to Martha M. Murray MD .

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Editors and Affiliations

  1. Boston Children's Hospital, Harvard Medical School, Department of Orthopedic Surgery, Longwood Avenue 300, Boston, 02115, Massachusetts, USA

    Martha M. Murray

  2. Boston Children's Hospital, Harvard Medical School, Department of Orthopedic Surgery, Longwood Avenue 300, Boston, 02115, Massachusetts, USA

    Patrick Vavken

  3. Brown University, Rhode Island Hospital, Warren Alpert Medical School, Hoppin Street 1, Providence, 02903, Rhode Island, USA

    Braden Fleming

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Murray, M.M. (2013). Use of Biologics to Treat Partial ACL Tears. In: Murray, M., Vavken, P., Fleming, B. (eds) The ACL Handbook. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0760-7_15

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  • DOI: https://doi.org/10.1007/978-1-4614-0760-7_15

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-0759-1

  • Online ISBN: 978-1-4614-0760-7

  • eBook Packages: MedicineMedicine (R0)

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