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Lensfree On-Chip Fluorescence Microscopy for High-Throughput Imaging of Bio-Chips

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Sensors

Abstract

On-chip fluorescence microscopy is an emerging platform that enables high-throughput screening of bio-chips over a wide field-of-view without the use of any lenses, thin-film filters or mechanical scanners. In this review, we summarize the recent advances in lensfree fluorescence microscopy and also discuss some of its unique capabilities toward high-throughput screening applications, including rare-cell imaging, on-chip cytometry and as well as micro-array research.

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Acknowledgements

Ozcan Research Group at UCLA gratefully acknowledges the support of the Presidential Early Career Award for Scientists and Engineers (PECASE), ARO Young Investigator Award, NSF CAREER Award, the ONR Young Investigator Award and the NIH Director’s New Innovator Award DP2OD006427 from the Office of The Director, NIH. The authors also acknowledge the support of the NSF BISH program (under Awards # 0754880 and 0930501). S. A. Arpali acknowledges the partial financial support provided by the Scientific Technological Research Council of Turkey (TUBITAK) as a postdoctoral research scholarship.

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Correspondence to Aydogan Ozcan .

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Coskun, A.F. et al. (2014). Lensfree On-Chip Fluorescence Microscopy for High-Throughput Imaging of Bio-Chips. In: Baldini, F., et al. Sensors. Lecture Notes in Electrical Engineering, vol 162. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3860-1_2

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  • DOI: https://doi.org/10.1007/978-1-4614-3860-1_2

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-3859-5

  • Online ISBN: 978-1-4614-3860-1

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