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Neurocognitive Dysfunction in Old Diabetes

Management and Treatment

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Diabetes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 771))

Abstract

Type 2 diabetes mellitus (T2DM) is a risk factor for cognitive decline. However, the etiology of dementia and cognitive impairment in people with T2DM is probably multifactorial, and the precise underlying mechanism remains unclear.

Good metabolic control in elderly subjects with T2DM may contribute to prevention of the development and/or progression of cognitive decline in elderly diabetic subjects, but hypoglycemia must be avoided. Appropriate well-balanced glycaemic control should be provided to diabetic subjects with cognitive impairment.

Demented diabetic patients tend to lose self-caring ability, and behavioural and psychological symptoms of dementia (BPSD) and depressive mood; the symptoms often associated with dementia, make the management of diabetes complicated and difficult. Considering the progressive aging world-wide, more research to investigate the association between T2DM and dementia process, as well as the best way to manage this population, will be important.

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References

  1. Stewart R, Liolitsa D. Type 2 diabetes mellitus, cognitive impairment and dementia. Diabetic Medicine 1999; 16:93–112.

    Article  CAS  PubMed  Google Scholar 

  2. Li L, Hölscher C. Common pathological processes in Alzheimer disease and type 2 diabetes: a review. Brain Res Rev 2007; 56: 384–402.

    Article  CAS  PubMed  Google Scholar 

  3. Ott A, Stolk RP, van Harskamp F et al. Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology 1999; 58: 1937–1941.

    Article  Google Scholar 

  4. Arvanitakis Z, Wilson RS, Bienias JL et al. Diabetes mellitus and risk of Alzheimer’s disease and decline in cognitive function. Arch Neural 2004; 61: 661–666.

    Article  Google Scholar 

  5. Peila R, Rodriguez BL, Launer LI Honolulu-Asia Aging Study. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies. Diabetes 2002; 51: 1256–1262.

    Article  CAS  PubMed  Google Scholar 

  6. Peila R, Rodriguez BL, White LR et al. Fasting insulin and incident dementia in an elderly population of Japanese-American men. Neurology 2004; 63: 228–233.

    Article  CAS  PubMed  Google Scholar 

  7. Cukierman T, Gerstein HC, Williamson JD. Cognitive decline and dementia in diabetes —systematic overview of prospective observational studies. Diabetologia 2005; 48: 2460–2469.

    Article  CAS  PubMed  Google Scholar 

  8. Strachan MWJ, Deary IJ, Ewing FME et al. Is type II diabetes associated with a decline in cognitive function? A critical review of published studies Diabetes Care 1997; 20: 438–445.

    Article  CAS  PubMed  Google Scholar 

  9. Kopf D, Frölich L. Risk of incident Alzheimer’s disease in diabetic patients: asystematic review of prospective trials. J Alzheimers Dis 2009; 16(4): 677–685.

    Article  PubMed  Google Scholar 

  10. Biessels GJ, Stackenborg S, Brunner E et al. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neural 2006; 5(1): 64–74.

    Article  Google Scholar 

  11. Strachan MW. RD Lawrence Lecture 2010. The brain as a target organ in Type 2 diabetes: exploring the links with cognitive impairment and dementia. Diabet Med 2011; 28(2): 141–147.

    Article  CAS  PubMed  Google Scholar 

  12. Umegaki H. Neurodegeneration in diabetes mellitus. In: Ahmad SI ed. Neurodegenerative Diseases. Austin/ New York: Landes Bioscience/Springer Science-Business Media, 2011:258–265.

    Google Scholar 

  13. Whitiner RA, Karter AJ, Yaffe K et al. Hypoglycemie episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 2009: 15; 301:1565–1572.

    Article  Google Scholar 

  14. Strachan MW. Reynolds RM, Marioni RE et al. Cognitive function, dementia and type 2 diabetes mellitus in the elderly. Nat Rev Endocrinol. 2011; 7(2): 108–114.

    Article  CAS  PubMed  Google Scholar 

  15. Folstcin MF, Folstein SE, McHugh PR. ‘Mini-Mental State’: a practical method of grading the cognitive function of patients or the clinician. J Psychiatr Res 1978; 12: 189–198.

    Article  Google Scholar 

  16. Sakurai T, Kuranaga M, Akisaki T et al. Differential mini-mental state examination profiles of older people with diabetes mellitus with early Alzheimer’s disease. J Am Geriatr Soc. 2007; 55(6): 955–956.

    Article  PubMed  Google Scholar 

  17. Fillenbaum GG, Wilkinson WE, Welsh KA et al. Discrimination between stages of Alzheimer’s disease with subsets of Mini-Mental State Examination items. An analysis of Consortium to Establish a Registry for Alzheimer’s Disease data. Arch Neurol 1994; 51: 916–921.

    Article  CAS  PubMed  Google Scholar 

  18. van den Berg E, Kloppenborg RP, Kessels RP et al. Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: A systematic comparison of their impact on cognition. Biochim Biophys Acta 2009; 1792(5): 470–481.

    Article  PubMed  Google Scholar 

  19. Cukierman-Yaffe T, Gerstein HC, Williamson JD et al. Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial; Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) Investigators. Diabetes Care 2009; 32: 221–226.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Peters R, Beckett N, Forette F et al. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet Neurol 2008; 7: 683–689.

    Article  CAS  PubMed  Google Scholar 

  21. Maggi S, Limongi F, Noale M et al. LSA Study Group. Diabetes as a risk factor for cognitive decline in older patients. Dement Geriatr Cogn Disord 2009; 27: 24–33.

    Article  CAS  PubMed  Google Scholar 

  22. Ikonomovic MD, Klunk WE, Abrahamson EE et al. Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer’s disease. Brain 2008; 131: 1630–1645.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Umegaki H, Kawamura T, Kawano N et al. Factors Associated with Cognitive Declines in Elderly Diabetics Dementia and Geriatric Cognitive Disorders Extra 2011; 1: 1–9.

    Article  PubMed  Google Scholar 

  24. Gradman TJ, Laws A, Thompson LW et al. Verbal learning and/or memory improves with glycemic control in older subjects with non-insulin-dependent diabetes mellitus. J Am Geriatr Soc 1993; 41: 1305–1312.

    Article  CAS  PubMed  Google Scholar 

  25. Meneilly GS, Cheung E, Tessier D et al. The effect of improved glycemic control on cognitive functions in the elderly patient with diabetes. J Gerontol 1993; 48: M117–M121.

    Article  CAS  PubMed  Google Scholar 

  26. Naor M, Steingruber HJ, Westhoff K et al. Cognitive function in elderly non-insulin-dependent diabetic patients before and after inpatient treatment for metabolic control. J Diabetes Complicat 1997; 11: 40–46.

    Article  CAS  PubMed  Google Scholar 

  27. Hewer W, Mussell M, Rist F et al. Short-term effects of improved glycemic control on cognitive function in patients with type 2 diabetes.Gerontology 2003; 49: 86–92.

    Article  CAS  PubMed  Google Scholar 

  28. Ryan CM, Freed MI, Rood JA et al. Improving metabolic control leads to better working memory in adults with type 2 diabetes. Diabetes Care 2006; 29: 345–351.

    Article  PubMed  Google Scholar 

  29. Abbatecola AM, Rizzo MR, Barbieri M et al. Postprandial plasma glucose excursions and cognitive functioning in aged type 2 diabetics. Neurology 2006; 67: 235–240.

    Article  CAS  PubMed  Google Scholar 

  30. Mussell M, Hewer W, Kulzer B et al. Effects of improved glycae Large prospective study are warranted regarding this issue. Diabet Med 2004; 21(11): 1253–1256.

    Article  CAS  PubMed  Google Scholar 

  31. American Diabetes Association: Standards of medical care for patients with diabetes mellitus. Diabetes care 2008; 31: S12–S54.

    Article  Google Scholar 

  32. AllWales Research into Elderly (AWARE) Study. Sinclair AJ, Girling AJ, Bayer AJ. Diabetes Res Clin Pract 2000; 50(3): 203–212.

    Article  Google Scholar 

  33. L Ruggiero, SR Rossi, RE Glasgow et al. Diabetes self-management. Self-reported recommendations and patterns in a large population, Diabetes Care 1997; 20: 568–576.

    Article  Google Scholar 

  34. TA Goodall, WK Halford. Self-management of diabetes mellitus: a critical review, Health Psychol 1990;10:l–8.

    Google Scholar 

  35. Panza F, Frisardi V, Capurso C et al. Late-life depression, mild cognitive impairment, and dementia: possible continuum? Am J Geriatr Psychiatry. 2010; 18(2): 98–116.

    Article  PubMed  Google Scholar 

  36. Iwata I, Munshi MN. Cognitive and psychosocial aspects of caring for elderly patients with diabetes. Curr Diab Rep 2009; 9(2): 140–146.

    Article  PubMed  Google Scholar 

  37. Lustman PJ, Anderson RJ, Freedland KE et al. Depression and poor glycemic control: A meta-analytic review of the literature. Diabetes Care 2000; 23: 934–942.

    Article  CAS  PubMed  Google Scholar 

  38. Dotson VM, Resnick SM, Zonderman AB. Differential association of concurrent, baseline, and average depressive symptoms with cognitive decline in older adults. Am J Geriatr Psychiatry 2008; 16: 318–330.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Ganguli M, Du Y, Dodge HH et al. Depressive symptoms and cognitive decline in late life: A prospective epidemiological study. Arch Gen Psychiatry 2006;63:153–160.

    Article  PubMed  Google Scholar 

  40. Lustman PJ, Clouse RE. Depression in diabetic patients: The relationship between mood and glycemic control. J Diabetes Complicat 2005;19:113–122.

    PubMed  Google Scholar 

  41. McNabney MK, Pandya N, Iwuagwu C et al. Differences in diabetes management of nursing home patients based on functional and cognitive status. J Am Med Dir Assoc 2005; 6: 375–382.

    Article  PubMed  Google Scholar 

  42. Feil DG, Lukman R, Simon B et al. Impact of dementia on caring for patients’ diabetes. Health Services Research and Development Center of Excellence, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA,USA.

    Google Scholar 

  43. Zheng L, Mack WJ, Dagerman KS et al. Metabolic changes associated with second-generation antipsychotic use in Alzheimer’s disease patients: the CATIE-AD study.Am J Psychiatry 2009; 166(5): 583–590.

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

    Hiroyuki Umegaki

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  1. Hiroyuki Umegaki
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Editors and Affiliations

  1. School of Science and Technology, Nottingham Trent University, Nottingham, UK

    Shamim I. Ahmad BSc, MSc, PhD

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© 2013 Landes Bioscience and Springer Science+Business Media

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Umegaki, H. (2013). Neurocognitive Dysfunction in Old Diabetes. In: Ahmad, S.I. (eds) Diabetes. Advances in Experimental Medicine and Biology, vol 771. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5441-0_33

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