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The Transgenerational Effects of Parental Exposure to Mutagens in Mammals

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Stress-Induced Mutagenesis

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Abstract

The review describes the transgenerational effects of parental exposure to ionizing radiation, chemical mutagens and anticancer drugs. The results of some recent animal studies showing elevated mutation rates in the non-exposed offspring of irradiated parents are presented and discussed. The possible mechanisms and implications of transgenerational instability are also discussed.

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Acknowledgment 

This work was supported by grants from the European Commission (NOTE, Contract Number 036465), Cancer Research UK (Contract Number C23612/A9483 and C23912/A12262), the Wellcome Trust (Contract Number 091106/Z/10/Z), and the EMF Biological Research Trust (Contract Number BRT 11/42).

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  1. Department of Genetics, University of Leicester, University Road, Leicester, LE1 7RH, UK

    Yuri E. Dubrova

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Correspondence to Yuri E. Dubrova .

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  1. , Department of Biological Sciences, Virginia Tech, 4100 Derring Lab, Blacksburg, 24061, Virginia, USA

    David Mittelman

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Dubrova, Y.E. (2013). The Transgenerational Effects of Parental Exposure to Mutagens in Mammals. In: Mittelman, D. (eds) Stress-Induced Mutagenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6280-4_12

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