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Devices and Implants Prepared Using Hot Melt Extrusion

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Melt Extrusion

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 9))

Abstract

The development of medical devices (MD) and implants presents unique challenges and requirements not seen in the development of oral solid dosage forms. Through the use of hot melt extrusion (HME), it is possible to engineer novel systems capable of achieving specific geometries and release characteristics that enable the therapy. With extrusion, it is also possible to create systems containing multiple active ingredients leading to treatments for some of the most pressing diseases today, including HIV/AIDS. This chapter discusses the formulation of and processing technologies used for the production MD and implants prepared using HME. Recent examples, including inserts and vaginal rings, are also discussed to illustrate these principles.

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Notes

  1. 1.

    Belgian work.

  2. 2.

    http://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/Overview/ClassifyYourDevice/ucm051512.htm

  3. 3.

    Costeux et al. (2011)

  4. 4.

    Martin (2008)

  5. 5.

    Amanat et al. (2010)

  6. 6.

    Malcolm (2003)

  7. 7.

    Malcolm et al. (2005)

  8. 8.

    Higuchi (1963)

  9. 9.

    Higuchi (1961)

  10. 10.

    Siepmann and Siepmann (2012)

  11. 11.

    Helbling et al. (2011)

  12. 12.

    Baker and Lonsdale (1974)

  13. 13.

    www.ipmglobal.org

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Author information

Authors and Affiliations

  1. Particle Sciences Inc., Bethlehem, PA, USA

    Andrew Loxley

Authors
  1. Andrew Loxley
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Correspondence to Andrew Loxley .

Editor information

Editors and Affiliations

  1. Department of Pharmaceutics, University of Mississippi School of Phar National Center for Natural Products Res, University, Mississippi, USA

    Michael A. Repka

  2. Pharma Ingredients & Services, BASF Corporation, Tarrytown, New York, USA

    Nigel Langley

  3. Bridgewater, New Jersey, USA

    James DiNunzio

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© 2013 American Association of Pharmaceutical Scientists

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Loxley, A. (2013). Devices and Implants Prepared Using Hot Melt Extrusion. In: Repka, M., Langley, N., DiNunzio, J. (eds) Melt Extrusion. AAPS Advances in the Pharmaceutical Sciences Series, vol 9. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8432-5_12

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