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Neurovascular Responses to Traumatic Brain Injury

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Vascular Mechanisms in CNS Trauma

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 5))

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Abstract

The coordinated action of cells within the neurovascular unit is critical for proper brain functioning. Traumatic brain injury causes cell injury and death, resulting in disruptions of the intricate interactions among the surviving cells. Neurons, oligodendrocytes, astrocytes, microglia, endothelial cells, and pericytes exhibit specific responses to injury. An examination of these responses is important in understanding the pathology after brain trauma, and will be reviewed in this chapter.

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Acknowledgement

Conflict of interests: None. Funding: R37NS037074-13 (EHL), RO1NS076694-02(EHL), P01NS055104-05 (EHL), R01NS0800991-01(KA), RO1NS049430-07(KVL), RO1NS069939-02 (KVL), K08N5057339-04 (JL).

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Authors and Affiliations

  1. Neuroprotection Research Laboratory and Department of Pediatrics, Division of Pediatric Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Josephine Lok

  2. Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Ken Arai, Wendy Leung, Takakuni Maki, Deepti Navaratna, Klaus van Leyen & Changhong Xing

  3. Radiology Department, Neuroprotection Research Lab, Massachusetts General Hospital, Charlestown, MA, USA

    Shu-zhen Guo

  4. Department of Neurology, Jilin University, Changchun, Jilin, China

    Limin Wu

  5. Department of Pediatrics, Division of Pediatric Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Natan Noviski

  6. Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Eng H. Lo

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  1. Josephine Lok
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  9. Limin Wu
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  11. Eng H. Lo
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Correspondence to Josephine Lok .

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Editors and Affiliations

  1. Departments of Neurology and Radiology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Eng H. Lo

  2. Department of Pediatrics, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Josephine Lok

  3. Department of Neurology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    MingMing Ning

  4. Department of Pediatrics, Massachusetts General Hospital Harbard Medical School, Boston, Massachusetts, USA

    Michael J. Whalen

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Lok, J. et al. (2014). Neurovascular Responses to Traumatic Brain Injury. In: Lo, E., Lok, J., Ning, M., Whalen, M. (eds) Vascular Mechanisms in CNS Trauma. Springer Series in Translational Stroke Research, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8690-9_5

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  • DOI: https://doi.org/10.1007/978-1-4614-8690-9_5

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