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Vascular Inflammation in Ischemic Stroke: Adhesion Receptors Controlling Leukocyte–Endothelial Interactions

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Immunological Mechanisms and Therapies in Brain Injuries and Stroke

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 6))

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Abstract

The contribution of leukocytes to the pathogenesis of ischemic stroke has been extensively studied and thoroughly documented. In this chapter, different aspects of leukocyte involvement in the lesion formation caused by ischemic stroke are highlighted, including the inflammatory agents that mediate leukocyte recruitment to the site of injury, the primary leukocyte populations that contribute to tissue damage, and the adhesion receptors that control leukocyte–endothelial cell interactions in post-ischemic brain. Agents that interfere with leukocyte recruitment in the brain are also addressed as potential therapeutic interventions for ischemic stroke.

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Authors and Affiliations

  1. Clinical and Toxicological Analyses, University of Sao Paulo, Sao Paulo, Brazil

    Stephen F. Rodrigues

  2. Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Baton Rouge, LA, USA

    D. Neil Granger

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  1. Stephen F. Rodrigues
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  2. D. Neil Granger
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Correspondence to D. Neil Granger .

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  1. University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Jun Chen

  2. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Xiaoming Hu

  3. Molecular Microbiology & Immunology, Oregon Health & Sciences University, Portland, Oregon, USA

    Mary Stenzel-Poore

  4. Loma Linda University, Loma Linda, California, USA

    John H. Zhang

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Rodrigues, S.F., Granger, D.N. (2014). Vascular Inflammation in Ischemic Stroke: Adhesion Receptors Controlling Leukocyte–Endothelial Interactions. In: Chen, J., Hu, X., Stenzel-Poore, M., Zhang, J. (eds) Immunological Mechanisms and Therapies in Brain Injuries and Stroke. Springer Series in Translational Stroke Research, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8915-3_3

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