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Disease Influence on BBB Transport in Neurodegenerative Disorders

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Drug Delivery to the Brain

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 10))

Abstract

For the pharmacotherapy of neurodegenerative diseases, drugs have to pass the blood–brain barrier (BBB). Many changes in BBB properties in neurodegeneration have been reported. Furthermore, the BBB seems to play an important role in the disease initiation and or progression. While information on unbound drug concentrations in plasma and brain are needed to decipher BBB transport properties and target site concentrations, and changes thereof in disease conditions, surprisingly, only a very limited number of BBB transport studies in neurodegeneration have been performed on the basis of the unbound drug, and even fewer have taken into account disease conditions and/or measurements of an effect parameter. For better understanding and treatment, a much more integrative and translational pharmacometric research approach is needed, instead of studying neurodegenerative components in isolation. As the human brain is not accessible for sampling, we have to rely on animal models and translational approaches.

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Authors and Affiliations

  1. Gorlaeus Laboratories, Division of Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands

    Elizabeth C. M. de Lange

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Correspondence to Elizabeth C. M. de Lange .

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  1. Pharmaceutical Biosciences, Uppsala University Pharmacokinetics and Drug Therapy, Uppsala, Sweden

    Margareta Hammarlund-Udenaes

  2. LACDR/Pharmacology, Leiden University, Leiden, The Netherlands

    Elizabeth C.M. de Lange

  3. Pharmaceutical Sciences Division, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA

    Robert G. Thorne

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de Lange, E.C.M. (2014). Disease Influence on BBB Transport in Neurodegenerative Disorders. In: Hammarlund-Udenaes, M., de Lange, E., Thorne, R. (eds) Drug Delivery to the Brain. AAPS Advances in the Pharmaceutical Sciences Series, vol 10. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9105-7_22

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