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Schizophrenia and Bipolar Disorder

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Behavior Genetics of Psychopathology

Part of the book series: Advances in Behavior Genetics ((AIBG,volume 2))

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Abstract

Research into the genetic basis of schizophrenia and bipolar disorder is advancing rapidly. In quantitative genetics, the evidence for substantial heritability has been further substantiated by large-scale analysis of a range of types of relatives, and there is a lengthening catalogue of other psychotic and nonpsychotic disorders that are likely to share some genetic risk factors with schizophrenia and bipolar disorder. In molecular genetics, genome-wide association studies are providing evidence of many common genetic variants which each make a small contribution to risk. At the chromosomal level, studies of copy number variants are showing rarer variants which have a larger effect on risk. Both types of study are reinforcing the theme that schizophrenia and bipolar disorder share some genetic influences with other disorders. In an effort to understand the genetics of schizophrenia and bipolar disorder by going beyond the diagnosis, there has been interest in both additional clinical phenotypes and the use of endophenotypes. Work is also beginning in the use of next-generation genetic sequencing to find new genetic variants and in moving further downstream to find the functional consequences of risk variants. In this chapter, we give a broad overview of these recent research developments against the background of successive phases of previous research and consider the probable next stages of research in this field.

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  1. Academic Unit of Psychiatry and Behavioural Sciences, Leeds Institute of Health Sciences, University of Leeds, Charles Thackrah Building, 101 Clarendon Road, Leeds, LS2 9LJ, UK

    Alastair G. Cardno & Edward Pepper

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    Soo Hyun Rhee

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    Angelica Ronald

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Cardno, A.G., Pepper, E. (2014). Schizophrenia and Bipolar Disorder. In: Rhee, S., Ronald, A. (eds) Behavior Genetics of Psychopathology. Advances in Behavior Genetics, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9509-3_6

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