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Myotonic Dystrophy: Discussion of Molecular Basis

  • Chapter
Triple Repeat Diseases of the Nervous Systems

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 516))

Abstract

Myotonic dystrophy 1 (DM1) is a dominant, neuromuscular disease which represents the most common form of muscular dystrophy with a frequency of 1 in 8,000. Today, there is no cure for this disease. Clinical manifestations vary from the almost asymptomatic condition to the deadly form of disease associated with increased disease severity in generations with reduction of age of onset.

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Authors and Affiliations

  1. Section of Cardiovascular Sciences, Departments of Medicine, Molecular Physiology Biophysics, Houston, TX, 77030, USA

    Lubov T. Timchenko

  2. Division of Human Biology, Fred Hutchinson Research Center, Seattle, WA, 98109, USA

    Steve J. Tapscott

  3. Departments of Pathology and Molecular and Cell Biology, Baylor College of Medicine, Houston, TX, 77030, USA

    Thomas A. Cooper

  4. Institute of Biomedical and Life Sciences, The University of Glasgow, Glasgow, G128QQ, UK

    Darren G. Monckton

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  1. Lubov T. Timchenko
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  2. Steve J. Tapscott
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  3. Thomas A. Cooper
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  4. Darren G. Monckton
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Editors and Affiliations

  1. Department of Medicine, Baylor College of Medicine, Houston, Texas, USA

    Lubov T. Timchenko

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Timchenko, L.T., Tapscott, S.J., Cooper, T.A., Monckton, D.G. (2002). Myotonic Dystrophy: Discussion of Molecular Basis. In: Timchenko, L.T. (eds) Triple Repeat Diseases of the Nervous Systems. Advances in Experimental Medicine and Biology, vol 516. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0117-6_2

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  • DOI: https://doi.org/10.1007/978-1-4615-0117-6_2

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