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PACAP Receptor Signaling

  • Chapter
Pituitary Adenylate Cyclase-Activating Polypeptide

Part of the book series: Endocrine Updates ((ENDO,volume 20))

Abstract

PACAP receptors have been identified in different tissues (Lam et al, 1990; Cauvin et al, 1991; Gottschall et al, 1991; Shivers et al, 1991; Tatsuno et al, 1991; Masuo et al, 1992) and three different types have been cloned (Harmar et al, 1998). One type is the specific PACAP receptor (PAC1-R, previously called the type I PACAP receptor or PVR1), which binds PACAP38 and PACAP27 with a high affinity, but binds VIP with a 1000-fold lower affinity. The two other types of receptors are the VPAC1-R, which was previously called type II PACAP receptor or PVR2-R or VIP1-R, as well as the VIP-R, and the VPAC2- R, which was previously called type III PACAP receptor or PVR3-R or VIP2-R. Both VPAC1 and VPAC2 receptors bind PACAP38, PACAP27 and VIP with a similar high affinity. The effects of PACAP are mediated through interaction with three types of G-protein-coupled receptors: PAC1-R, VPAC1-R and VPAC2-R (Harmar et al, 1998). VPAC1-R and VPAC2-R are the common receptors for both PACAP and VIP, and they are mainly distributed in peripheral tissues (Ishihara et al, 1992; Lutz et al, 1993).

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Authors and Affiliations

  1. Showa University, Shinagawa-ku, Tokyo, Japan

    S. Shioda, C. JI Zhou & H. Ohtaki

  2. Jichi University, Tochigi, Japan

    T. Yada

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  1. European Institute for Peptide Research, INSERM Unit 413, University of Rouen, Mont-Saint-Aignan, France

    Hubert Vaudry

  2. US Japan Biomedial Research Laboratories, Tulane University, Belle Chasse, Louisiana, USA

    Akira Arimura

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Shioda, S., Zhou, C.J., Ohtaki, H., Yada, T. (2003). PACAP Receptor Signaling. In: Vaudry, H., Arimura, A. (eds) Pituitary Adenylate Cyclase-Activating Polypeptide. Endocrine Updates, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0243-2_5

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  • DOI: https://doi.org/10.1007/978-1-4615-0243-2_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4983-9

  • Online ISBN: 978-1-4615-0243-2

  • eBook Packages: Springer Book Archive

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