Abstract
There is substantial evidence that besides the volume fraction of the bone (often quantified in terms of apparent bone density) the three-dimensional arrangement of the trabecular network is a major determinant of elastic modulus1-5and ultimate strength.6-8
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Bibliography
R. Hodgkinson and J. D. Currey, The Effect of Variation in Structure on the Young’s Modulus of Cancellous Bone: A Comparison of Human and Non-Human Material.Proc. Instn. Mech. Engrs.?204?115 (1990).
M. J. Ciarelli, S. A. Goldstein, J. L. Kuhn, D. D. Cody, and M. B. Brown, Evaluation of orthogonal mechanical properties and density of human trabecular bone from the major metaphyseal regions with materials testing and computed tomography.J. Orthop. Res.?9?674 (1991).
S. A. Goldstein, R. Goulet, and D. McCubbrey, Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone.Calcif. Tissue Int.?53?S127 (1993).
S. N. Hwang, F. W. Wehrli, and J. L. Williams, Probability-based structural parameters from 3D NMR images as predictors of trabecular bone strength.Med. Phys.?24?1255 (1997).
B. G. Gomberg, P. K. Saha, H. K. Song, S. N. Hwang, and F. W. Wehrli, Application of topological analysis to magnetic resonance images of human trabecular bone.IEEE Trans. Med. Im.?19?166 (2000).
R. W. Goulet, S. A. Goldstein, M. J. Ciarelli, J. L. Kuhn, M. B. Brown, and L. A. Feldkamp, The relationship between the structural and orthogonal compressive properties of trabecular bone.J. Biomech.?27?375 (1994).
Z. M. Oden, D. M. Selvitelli, W. C. Hayes, and E. R. Myers, The effect of trabecular structure on DXA-based predictions of bovine bone failure.Calcif Tissue Int?63?67 (1998).
C. L. Gordon, C. E. Webber, and P. S. Nicholson, Relation between image-based assessment of distal radius trabecular structure and compressive strength.Bioeng.?49?390 (1998).
M. Kleerekoper, A. R. Villanueva, J. Stanciu, D. Sudhaker Rao, and A. M. Partitt, The Role of Three- Dimensional Trabecular Microstructure in the Pathogenesis of Vertebral Compression Fractures.Calcif. Tissue Int.?37?594 (1985).
R. R. Recker, Architecture and vertebral fracture.Calcif. Tissue Int.?53 Suppl 1?S139 (1993).
E. Legrand, D. Chappard, C. Pascaretti, M. Duquenne, S. Krebs, V. Rohmer, M. F. Basle, and M. Audran, Trabecular bone microarchitecture, bone mineral density and vertebral fractures in male osteoporosis.J. Bone Miner. Res.?15?13 (2000).
J. Ma, F. W. Wehrli, and H. K. Song, Fast 3D large-angle spin-echo imaging (3D FLASE).Magn. Reson. Med.?35?903 (1996).
S. Majumdar, H. K. Genant, S. Grampp, D. C. Newitt, V.-H. Truong, J. C. Lin, and A. Mathur, Correlation of trabecular bone structure with age, bone, mineral density, and osteoporotic status: in vivo studies in the distal radius using high-resolution magnetic resonance imaging.J. Bone Miner. Res?.12?111 (1997).
H. K. Song and F. W. Wehrli, In vivo micro-imaging using alternating navigator echoes with applications to cancellous bone structural analysis.Magn. Reson. Med.?41?947 (1999).
A. Laib, T. Hildebrand, H. J. Hauselmann, and P. Ruegsegger, Ridge number density: a new parameter for in vivo bone structure analysis.Bone?21?541 (1997).
A. Laib, H. J. Hauselmann, and P. Rüegsegger, In vivo high resolution 3D-QCT of the human forearm.Tech. Health Care?6?329 (1998).
C. L. Gordon, C. E. Webber, N. Christoforou, and C. NahmiasIn vivo?assessment of trabecular bone structure at the distal radius from high-resolution magnetic resonance images.Med. Phys.?24?585 (1997).
F. W. Wehrli, S. N. Hwang, J. Ma, H. K. Song, J. C. Ford, and J. G. Haddad, Cancellous bone volume and structure in the forearm: noninvasive assessment with MR microimaging and image processing [published erratum appears in Radiology 1998 Jun;207(3):8331.Radiology?206?347 (1998).
T. M. Link, S. Majumdar, P. Augat, J. C. Lin, D. Newitt, Y. Lu, N. E. Lane, and H. K. Genant, In vivo high resolution MRI of the calcaneus: differences in trabecular structure in osteoporosis patients.J. Bone Miner. Res.?13?1175 (1998).
R. L.Ehman and J. P. Felmlee, Adaptive technique for high-definition MR imaging of moving structures.Radiology?173?255 (1989).
D. Atkinson, D. L. G. Hill, P. N. R. Stoyle, P. E. Summers, and S. F. Keevil, Automatic correction of motion artifacts in magnetic resonance images using an entropy focus criterion.IEEE Trans. Med. Im.?16?903 (1997).
H. K. Song and F. W. Wehrli, Comparison of different motion correction schemes for in vivo microimaging, Proc ISMRM, Seventh Scientific Meeting (Int Soc Magnetic Resonance in Medicine, Philadelphia, 1999), pp. 2120.
H. W. Chung, F. W. Wehrli, J. L. Williams, S. D. Kugelmass, and S. L. Wehrli, Quantitative analysis of trabecular microstructure by 400 MHz nuclear magnetic resonance imaging.J. Bone Miner. Res.?10?, 803 (1995).
S. N. Hwang and F. W. Wehrli, Estimating voxel volume fractions of trabecular bone on the basis of magnetic resonance images acquired in vivo. Int. J. Im. Syst. Technol. 10?186 (1999).
S. N. Hwang and F. W. Wehrli, Subvoxel processing: a new method for alleviating partial volume blurring in MR images of trabecular bone, Proc Int Soc Magnetic Resonance in Medicine, Eighth]nt Meeting (Int Soc Magnetic Resonance in Medicine, Denver, 2000), pp. 2134.
Z. Wu, H. Chung, and F. W. Wehrli, A Bayesian approach to subvoxel tissue classification in NMR microscopic images of trabecular bone.Magn. Reson. Med.?31?, 302 (1994).
P. K. Saha, B. R. Gomberg, and F. W. Wehrli, Three-dimensional digital topological characterization of cancellous bone architecture.Int. J. lin. Syst. Technol.?11?, 81 (2000).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media New York
About this chapter
Cite this chapter
Wehrli, F.W., Hwang, S.N., Song, H.K., Gomberg, B.R. (2001). Visualization and Analysis of Trabecular Bone Architecture in the Limited Spatial Resolution Regime of In Vivo Micro-MRI. In: Majumdar, S., Bay, B.K. (eds) Noninvasive Assessment of Trabecular Bone Architecture and the Competence of Bone. Advances in Experimental Medicine and Biology, vol 496. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0651-5_16
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0651-5_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5177-1
Online ISBN: 978-1-4615-0651-5
eBook Packages: Springer Book Archive