Abstract
Bicarbonate anion (HCO -3 ) is present at high concentration (25 mM) in biological fluids. At this HCO3 concentration, the carbon-di-oxide (CO2) concentration is estimated to be ca. 1.2 mM at physiological conditions. A major function of the HCO -3 CO2 couple in biological systems is to regulate pH. Although HCO -3 -mediated enhancement of luminol oxidation was reported several decades ago (Hodgson and Fridovich, 1976), only recently was the role of HCO -3 recognized in biological oxidations (Denicola et al 1996; Ischiropoulos et al 1992; Lymar et al 1996; Singh et al 1998; Zhang et al 1997).
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Kalyanaraman, B., Joseph, J., Zhang, H. (2001). Bicarbonate Enhances Nitration and Oxidation Reactions in Biological Systems—Role of Reactive Oxygen and Nitrogen Species. In: Dansette, P.M., et al. Biological Reactive Intermediates VI. Advances in Experimental Medicine and Biology, vol 500. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0667-6_23
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