Abstract
DNA content detected by video-imaging and flow cytometry in malignant and premalignant cells becomes more and more often routine adjunct to clinical and histological diagnosis. It seems that the presence of abnormal DNA in many neoplasms is correlated with the poor clinical course (1,4,5). However, diploid cell population was found also in such malignant cell transformations as leukemia, lymphoma, and aneuploidy in such benign transformations as thyroid adenoma, mastopathy and premalignant cutaneous lesions. It is clear that DNA ploidy is not always an adequate parameter to differentiate benign from malignant lesions.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barlogie B, Raber MC, Schumann J, Johnson TS, Drewinko B et al. Flow Cytometry in Clinical Cancer Research. Cancer Res 1983; 43: 3982–3997
Barnhill RL, Aguiar M, Cohen C, Kang S, Kennedy J, Schmidt B, Sober AJ, Solomon AR. Congenital Melanocytic Nevi and DNA Content. An Analysis by Flow and Image Cytometry. Cancer 1994; 74: 2935–2943
Bartkowiak D, Schumann J, Otto FJ et al. DNA Flow Cytometry in the Prognosis of Primary Malignant Melanoma. Oncology 1991; 48: 39–43
Buchner T, Hiddemann W, Wormann B et al. Differential pattern of DNA-aneuploidy in human malignancy. Pathol Res Pract 1985; 179: 310–317
Skowronek J, Adamska K, Filipiak K, Kara¡ì Z, Krenz RM, Rutkowski R, Warchol JB - DNA ploidy in malignant melanoma, skin cancer and pigmented nevi, Neoplasma 1997; 44: 282–288
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media New York
About this chapter
Cite this chapter
Skowronek, J., Karas, Z., Krenz, R.M., Warchoł, J.B. (2001). Flow and video-imaging cytometry — usefulness of DNA ploidy measurements in diagnosis of malignant melanoma. In: Mackiewicz, A., Kurpisz, M., Żeromski, J. (eds) Progress in Basic and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 495. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0685-0_63
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0685-0_63
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5194-8
Online ISBN: 978-1-4615-0685-0
eBook Packages: Springer Book Archive