Abstract
Epidemiological and laboratory findings have long implicated a potential anti-cancer activity of the trace element nutrient selenium (Se). Note that it is often for convenience reasons to describe such anti-cancer activity in terms of the element. A vast volume of data have been accumulated supporting the theme that cancer preventive activity is expressed as a function of the dose and chemical form in which the element resides, not elemental Se per se (1,2). The landmark cancer prevention trial by Clark, Combs and coworkers demonstrated for the first time that a supra-nutritional Se supplement (provided as selenized yeast) to a US skin cancer patient population otherwise adequate in Se nutrition might be an effective preventive agent for several major human epithelial cancers (3). With profound public health implications at stake, many serious issues demand a clear understanding of the mechanisms through which Se exerts anti-cancer activity. Some of these pressing questions, for example, include what form(s) and what doses of Se should be used? What populations should be given the intervention? How long should the intervention be given?
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Lu, J. (2001). Apoptosis and Angiogenesis in Cancer Prevention by Selenium. In: Nutrition and Cancer Prevention. Advances in Experimental Medicine and Biology, vol 492. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1283-7_11
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DOI: https://doi.org/10.1007/978-1-4615-1283-7_11
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