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Survey of Cutaneous T Cell Lymphomas for Human T-Lymphotropic Virus Infection

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Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin

Part of the book series: NATO ASI Series ((NSSA,volume 265))

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Abstract

The etiology of cutaneous T cell lymphomas (CTCL) is still unknown, but the similarities it shares with the human T-lymphotropic virus type-1 (HTLV-associated adult T cell lymphoma led to the speculation that a retrovirus may be involved as a causative agent. Many studies using electron microscopy and serological tests have supported this hypothesis. The recently available powerful techniques of molecular biology (D’Incan et al., 1992a) have shown that some cases of cutaneous T cell lymphomas outside HTLV-1 endemic areas are associated with the genomic integration of a related or, more probably, a defective HTLV-1 provirus. To date, no viral isolate was established from a case of CTCL. Moreover, the incidence of a retroviral infection in CTCL seems to be low although highly underestimated.

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Author information

Authors and Affiliations

  1. Dermatology Department, Hotel-Dieu, Clermont-Ferrand, France

    Michel D’Incan & Pierre Souteyrand

  2. Laboratory of Viral Hepatitis, AIDS and Human Retroviruses, INSERM, Lyon, France

    Michel D’Incan & Claude Desgranges

  3. Molecular Oncology Department, Centre Jean Perrin, Clermont-Ferrand, France

    Yves-Jean Bignon

Authors
  1. Michel D’Incan
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  2. Pierre Souteyrand
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  3. Yves-Jean Bignon
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  4. Claude Desgranges
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Editor information

Editors and Affiliations

  1. UMD-New Jersey Medical School, Newark, New Jersey, USA

    W. Clark Lambert

  2. University of Florence, Florence, Italy

    Benvenuto Giannotti

  3. University Hospital, Utrecht, Utrecht, The Netherlands

    Willem A. van Vloten

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© 1994 Springer Science+Business Media New York

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D’Incan, M., Souteyrand, P., Bignon, YJ., Desgranges, C. (1994). Survey of Cutaneous T Cell Lymphomas for Human T-Lymphotropic Virus Infection. In: Lambert, W.C., Giannotti, B., van Vloten, W.A. (eds) Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin. NATO ASI Series, vol 265. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1861-7_13

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  • DOI: https://doi.org/10.1007/978-1-4615-1861-7_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5756-8

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