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The Limbic System and Stress Ulcers

  • Chapter
Neuroendocrinology of Gastrointestinal Ulceration

Part of the book series: Hans Selye Symposia on Neuroendocrinology and Stress ((HSSN,volume 2))

Abstract

Our working hypothesis, over the past decade, has been that the limbic system modulates stress ulcer susceptibility1,2. It was largely based on early reports in the literature that linked (in a vague kind of way) this system of interconnected brain structures to the development of so-called “psychosomatic” disorders. In 1949 MacLean3, elaborating on the Papez4 theory of emotions, proposed that the limbic system might represent a primitive “visceral brain”, responsible for the development of psychosomatic diseases. Much of the evidence was based on case reports from patients with temporal lobe epilepsies. Patients with so-called uncinate fits were described, whose feelings of terror were also sometimes associated with visceral auras, i.e., various gastric and intestinal symptoms, ranging from epigastric uneasiness, chewing movements and grinding of the teeth, to feelings of hunger and frequent defecation and urination. Correspondingly, the data from early animal studies indicated that parts of the limbic system might be involved in emotional behavior. Klüver and Bucy5 had reported that monkeys with bilateral temporal lobectomies became tame and docile, showed a collection of symptoms which were labelled “psychic blindness”, displayed various “oral tendencies”, and engaged in bizarre sexual activities. It appeared that the monkeys could no longer discriminate between potentially dangerous objects and objects that might be useful to them. One interpretation of these studies is that the brain lesions had disconnected sensory inputs from the appropriate, adaptive behaviors. Later experiments showed that many of the effects of these radical lobectomies could be traced to damage in the amygdala6. These findings lead to the proposal that the amygdala connects sensory inputs with emotional and visceral responses, based on the recognition that a particular situation may be threatening to the organism7.

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References

  1. P.G. Henke, The hypothalamus-amygdala axis and experimental gastric ulcers, Neurosci Biobehav Rev. 3:75 (1979).

    Article  Google Scholar 

  2. P.G. Henke, The telencephalic limbic system and experimental gastric pathology: A review, Neurosci Biobehav Rev. 6:381 (1982).

    Article  PubMed  CAS  Google Scholar 

  3. P.D. MacLean, Psychosomatic disease and the “visceral brain”: Recent developments bearing on the Papez theory of emotion, Psychosom Med. 11:338 (1949).

    PubMed  CAS  Google Scholar 

  4. J.W. Papez, A proposed mechanism of emotion, Arch Neurol Psychiat. 38:725 (1937).

    Article  Google Scholar 

  5. H. Klüver and P.C. Bucy, Preliminary analysis of functions of the temporal lobes in monkeys, Arch Neurol Psychiat. 42:979 (1934).

    Article  Google Scholar 

  6. G.V. Goddard, Functions of the amygdala, Psychol Bull. 62:87 (1964).

    Article  Google Scholar 

  7. P.G. Henke, The amygdala and forced immobilization of rats, Behav Brain Res. 16:19 (1985).

    Article  PubMed  CAS  Google Scholar 

  8. P.I. Yakovlev, Motility, behavior, and the brain, J Nerv Merit Dis. 107:313 (1948).

    Article  CAS  Google Scholar 

  9. J.A. Gray. “The neuropsychology of anxiety,” Oxford University Press, New York (1982).

    Book  Google Scholar 

  10. G. Powell. “Brain and personality,” Praeger Publishers, New York (1979).

    Google Scholar 

  11. M. Bucaille, Electrocoagulations du cerveau préfrontal: Indications et résultats dans les ulcères gastriques et duodénaux rebelles, Acta gastro-enter (belg.). 20:506 (1957).

    CAS  Google Scholar 

  12. M. Bucaille, Fontal lobe operation for colitis, Surgery. 52:690 (1962).

    PubMed  CAS  Google Scholar 

  13. R.L. Isaacson. “The limbic system,” Plenum Press, New York (1982).

    Google Scholar 

  14. R.J. Douglas, The development of hippocampal function: Implications for theory and for therapy,in: “The Hippocampus (Vol. 2),” R.L. Isaacson, K.H. Pribram, eds., Plenum Press, New York (1975).

    Google Scholar 

  15. P.G. Henke, Granule cell potentials in the dentate gyrus of the hippocampus: Coping behavior and stress ulcers in rats, Behav Brain Res. 30:97 (1990).

    Article  Google Scholar 

  16. B.R. Kaada, Stimulation and regional ablation of the amygdaloid complex with reference to functional representations, in: “The Neurobiology of the Amygdala,” B.E. Eleftheriou, ed., Plenum Press, New York (1972).

    Google Scholar 

  17. H. Koikegami, Amygdala and other related limbic structures. II. Functional experiments, Acta Med Biol. 12:73 (1964).

    PubMed  CAS  Google Scholar 

  18. P. Gloor, Inputs and outputs of the amygdala: What the amygdala is trying to tell the rest of the brain, in: “Limbic Mechanisms,” K.E. Livingston, D. Hornykiewicz, eds., Plenum Press, New York (1978).

    Google Scholar 

  19. H.J. Lammers, The neural connections of the amygdaloid complex in mammals, in: “The Neurobiology of the Amygdala,” B.E. Eleftheriou, ed., Plenum Press, New York (1972).

    Google Scholar 

  20. J.E. LeDoux, D.A. Ruggiero, and D.J. Reis, Projections to the subcortical forebrain from anatomically defined regions of the medial geniculate body in the rat, J Comp Neurol. 242:182 (1985).

    Article  PubMed  CAS  Google Scholar 

  21. R. Norgren, Taste pathways to the hypothalamus and amygdala, J Comp Neurol. 166:17 (1976).

    Article  PubMed  CAS  Google Scholar 

  22. O.P. Ottersen and Y. Ben-Ari, Afferent connections to the amygdaloid complex of the rat and cat.I. Projections from the thalamus, J Comp Neurol. 187:401 (1979).

    Article  PubMed  CAS  Google Scholar 

  23. R.J. Radna and P.D. MacLean, Effects of vagal volleys on unit activity of amygdala, hippocampus,and corpus striatum in squirrel monkeys (Saimiri sciureus), Soc Neurosci Abstr. 2:374 (1976).

    Google Scholar 

  24. R.N. Sen and B.K. Anand, Effect of electrical stimulation of the limbic system of brain (“visceral brain”) on gastric secretory activity and ulceration, Indian J Med Res. 45:515 (1957).

    PubMed  CAS  Google Scholar 

  25. C.N. Shealy and T.L. Peele, Studies on amygdaloid nucleus in the cat, J Neurophysiol. 20:125 (1957).

    PubMed  CAS  Google Scholar 

  26. E.J. Zawoisky, Gastric secretory response of the unrestrained cat following electrical stimulation of the hypothalamus, amygdala and basal ganglia, Exp Neurol. 17:128 (1967).

    Article  Google Scholar 

  27. G. Stock, U. Rupprecht, H. Stumpf, and K. Schlör, Cardiovascular changes during arousal elicited by stimulation of amygdala, hypothalamus and locus coeruleus, J Autonom Nerv Syst. 3:503 (1981).

    Article  CAS  Google Scholar 

  28. G. Stock, K.H. Schlör, H. Heidt, and J. Buss, Psychomotor behaviour and cardiovascular patterns during stimulation of the amygdala, Pflügers Arch. 376:177 (1978).

    Article  PubMed  CAS  Google Scholar 

  29. R.J. Timms, A study of the amygdaloid defense reaction showing the value of Althesin anesthesia in studies of the functions of the fore-brain in cats, Pflügers Arch. 391:49 (1981).

    Article  PubMed  CAS  Google Scholar 

  30. H.A. Koikegami, A. Komoto, and C. Kido, Studies on the amygdaloid nuclei and periamygdaloid complex: Experiments on the influence of their stimulation upon motility of small intestine and blood pressure, Folia Psychiat Neurol Jap. 7:86 (1953).

    Google Scholar 

  31. S. Eliasson, Cerebral influence on gastric motility in the cat, Acta Physiol Scand. 26 (Suppl. 95):1 (1952).

    CAS  Google Scholar 

  32. F.M. Fennegan and M.J. Puiggari, Hypothalamic and amygdaloid influences on gastric motility in dogs, J Neurosurg. 24:497(1966).

    Article  PubMed  CAS  Google Scholar 

  33. P.G. Henke, Recent studies of the central nucleus of the amygdala and stress ulcers, Neurosci Biobehav Rev. 12:143 (1988).

    Article  PubMed  CAS  Google Scholar 

  34. D.L. Innes and M.F. Tansy, Gastric mucosal ulceration associated with electrochemical stimulation of the limbic brain, Brain Res Bull. 5 (Suppl. 1):33 (1980).

    Article  PubMed  CAS  Google Scholar 

  35. P.G. Henke, The centromedial amygdala and gastric pathology in rats, Physiol Behav. 25:107 (1980).

    Article  PubMed  CAS  Google Scholar 

  36. D.A. Hopkins and G. Holstege, Amygdaloid projections to the mesencephalon, pons and medulla oblongata in the cat, Exp Brain Res. 32:529 (1978).

    Article  PubMed  CAS  Google Scholar 

  37. J.E. Krettek and J.L. Price, Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat, J Comp Neurol. 178:225 (1978).

    Article  PubMed  CAS  Google Scholar 

  38. J.S. Schwaber, B.S. Kapp, G.A. Higgins, and P.R. Rapp, Amygdaloid and basal forebrain direct connections with the nucleus of the solitary tract and the dorsal motor nucleus, J Neurosci. 2:1424 (1982).

    PubMed  CAS  Google Scholar 

  39. P.G. Henke, Limbic system modulation of stress ulcer development, Ann NY Acad Sci. 597:201 (1990).

    Article  PubMed  CAS  Google Scholar 

  40. J.L. Price, The efferent projections of the amygdaloid complex in the rat, cat and monkey, in: “The Amygdaloid Complex,” Y. Ben-Ari, ed., Elsevier/North-Holland Biomedical Press, Amsterdam (1981).

    Google Scholar 

  41. P.G. Henke, The amygdala and restraint ulcers in rats, J Comp Physiol Psychol. 84:313 (1980).

    Article  Google Scholar 

  42. P.G. Henke, Facilitation and inhibition of gastric pathology after lesions in the amygdala of rats, Physiol Behav. 25:575 (1980).

    Article  PubMed  CAS  Google Scholar 

  43. P.G. Henke and R.M. Sullivan, Kindling in the amygdala and susceptibility to stress ulcers, Brain Res Bull. 14:5 (1985).

    Article  PubMed  CAS  Google Scholar 

  44. P.G. Henke, Electrophysiological activity in the central nucleus of the amygdala: Emotionality and stress ulcers in rats, Behav Neurosci. 102:77 (1988).

    Article  PubMed  CAS  Google Scholar 

  45. P. Driscoll and K. Bättig, Behavioral, emotional and neurochemical profiles of rats selected for extreme differences in active, two-way avoidance performance, in: “Genetics of the Brain,” I. Lieblich, ed., Elsevier Biomedical Press, Amsterdam (1982).

    Google Scholar 

  46. G. Glavin, Restraint ulcer: History, current research and future implications, Brain Res Bull. 5 (Suppl. 1):51 (1980).

    Article  PubMed  Google Scholar 

  47. G.B. Glavin and R.E. Ykema, Subject emotionality and subsequent pylorus ligation induced or restraint induced gastric ulcer, Pavlovian J Biol Sci. 15:102 (1980).

    CAS  Google Scholar 

  48. A. Ray, P.G. Henke, and R.M. Sullivan, Central dopamine systems and gastric stress pathology in rats, Physiol Behav. 42:359 (1988).

    Article  PubMed  CAS  Google Scholar 

  49. A.Y. Deutsch, M. Goldstein, F. Baldino, and R.H. Roth, Telencephalic projections of the A8 dopamine cell group, Ann NY Acad Sci. 537:27 (1988).

    Article  Google Scholar 

  50. J.H. Fallon, Histochemical characterization of dopaminergic, noradrenergic and serotonergic projections to the amygdala, in: “The Amygdaloid Complex,” Y. Ben-Ari, ed., Elsevier/North-Holland Biomedical Press, Amsterdam (1981).

    Google Scholar 

  51. G.W. Roberts, P.L. Woodham, J.M. Polak, and T.J. Crow, Distribution of neuropeptides in the limbic system of the rat: The amygdaloid complex, Neuroscience. 7:99 (1982).

    Article  PubMed  CAS  Google Scholar 

  52. G.W. Roberts, J.M. Polak, and T.J. Crow, Peptide circuitry of the limbic system, in: “Psychopharmacology of the Limbic System,” M.R. Trimble, E. Zarifian, eds., Oxford University Press, Oxford (1985).

    Google Scholar 

  53. N. Sharif and D. Burt, Limbic, hypothalamic, cortical and spinal regions are enriched with receptors of thyrotropin-releasing hormone: Evidence from [3H] ultrafilm autoradiography and correlation with cerebral effects of the tripeptide in rat brain, Neurosci Lett. 60:337 (1985).

    Article  PubMed  CAS  Google Scholar 

  54. T.H. Williams, M.D. Cassell, N.J. Mankovich, H.K. Huang, and T.S. Gray, The distribution of neuropeptides in the central nucleus of the amygdala: A quantitative approach using image analysis, in: “The Amygdaloid Complex,” Y. Ben-Ari, ed., Elsevier/North-Holland Biomedical Press, Amsterdam (1981).

    Google Scholar 

  55. P.G. Henke, R.M. Sullivan, and A. Ray, Interactions of thyrotropin-releasing hormone with neurotensin and dopamine in the central nucleus of the amygdala during stress ulcer formation in rats, Neurosci Lett. 91:95 (1988).

    Article  PubMed  CAS  Google Scholar 

  56. A. Ray, P.G. Henke, and R.M. Sullivan, The central amygdala and immobilization stress induced gastric pathology in rats: Neurotensin and dopamine, Brain Res. 409:398 (1987).

    Article  PubMed  CAS  Google Scholar 

  57. A. Ray, P.G. Henke, and R.M. Sullivan, Effects of intra- amygdalar dopamine agonists and antagonists on gastric stress lesions in rats, Neurosci Lett. 84:302 (1988).

    Article  PubMed  CAS  Google Scholar 

  58. A. Ray and P.G. Henke, Role of dopaminergic mechanisms in the central amygdalar nucleus in the regulation of stress-induced gastric ulcer formation in rats, Indian J Med Res. 90:224 (1989).

    PubMed  CAS  Google Scholar 

  59. A. Ray, P.G. Henke, and R.M. Sullivan, Opiate mechanisms in the central amygdala and gastric stress pathology in rats, Brain Res. 442:195 (1988).

    Article  PubMed  CAS  Google Scholar 

  60. A. Ray and P.G. Henke, Enkephalin-dopamine interactions in the central amygdalar nucleus during gastric stress ulcer formation in rats, Behav Brain Res. 36:179 (1990).

    Article  PubMed  CAS  Google Scholar 

  61. R.M. Sullivan, P.G. Henke, A. Ray, M.A. Hebert, and J.M. Trimper, The GABA/ benzodiazepine receptor complex in the central amygdalar nucleus and stress ulcers in rats, Beltav Neur Biol. 51:262 (1989).

    Article  CAS  Google Scholar 

  62. A. Ray, P.G. Henke, and R.M. Sullivan, Effects of intra-amygdalar thyrotropin releasing hormone (TRH) and its antagonism by atopine and benzodiazepines during stress ulcer formation in rats, Pharmacol Biochem Behav. 36:597 (1990).

    Article  PubMed  CAS  Google Scholar 

  63. D.G. Amaral, J.L. Price, A. Pitkanen, and T.S. Carmichael, Anatomical organization of the primate amygdaloid complex, in: “The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction,” J.P. Aggleton, ed., Wiley-Liss, New York (1992).

    Google Scholar 

  64. E. Costa, M.G. Corda, B. Epstein, C. Forchetti, and A. Guidotti, GABA-benzodiazepine interactions, in: “The Benzodiazepines: From Molecular Biology to Clinical Practice,” E. Costa, ed., Raven Press, New York (1983).

    Google Scholar 

  65. K. Shibata, Y. Kataoka, Y. Gomita, and S. Ueki, Localization of the site of the anticonflict action of benzodiazepines in the amygdaloid nucleus of rats, Brain Res. 234:442 (1982).

    Article  PubMed  CAS  Google Scholar 

  66. K. Nakamura, T. Hayashi, and K. Nakamura, Effects of bromazepam on cerebral neuronal activity in male Wistar rats with immobilized stress, Folia Pharmacol Jap. 83:401 (1984).

    Article  PubMed  CAS  Google Scholar 

  67. P. Gloor, A. Oliver, and L.F. Quesney, The role of the amygdala in the expression of psychic phenomena in temporal lobe seizures, in: “The Amygdaloid Complex,” Y. Ben-Ari, ed., Elsevier/North-Holland Biomedical Press, Amsterdam (1981).

    Google Scholar 

  68. W.P. Chapman, H.R. Schroeder, G. Geyer, M.A.B. Brazier, C. Fager, J.L. Poppen, H.C. Solomon, and P.I. Yakovlev, Physiological evidence concerning the importance of the amygdaloid nuclear region in the integration of circulating function and emotion in man, Science. 129:949 (1954).

    Article  Google Scholar 

  69. CD. Applegate, B.S. Kapp, M.D. Underwood, and C.L. McNall, Autonomic and somatomotor effects of amygdala central n. stimulation in awake rabbits, Physiol Behav. 31:353 (1983).

    Article  PubMed  CAS  Google Scholar 

  70. B.S. Kapp, M. Gallagher, M.D. Underwood, C.L. McNall, and D. Whitehorn, Cardiovascular responses elicited by electrical stimulation of the amygdala central nucleus in the rabbit, Brain Res. 234:251 (1982).

    Article  PubMed  CAS  Google Scholar 

  71. G.J. Mogenson and F.R. Calaresu, Cardiovascular responses to electrical stimulation of the amygdala in the rat, Exp Neurol. 39:166 (1973).

    Article  PubMed  CAS  Google Scholar 

  72. R.M. Harper, R.C. Frysinger, R.B. Trelease, and J.D. Marks, State-dependent alteration of respiratory cycle timing by stimulation of the central nucleus of the amgydala, Brain Res. 306:1 (1984).

    Article  PubMed  CAS  Google Scholar 

  73. J.B. Rosen and M. Davis, Enhancement of acoustic startle by electrical stimulation of the amygdala, Behav Neurosci 102:195 (1988).

    Article  PubMed  CAS  Google Scholar 

  74. P.G. Henke, Unit-activity in the central amygdalar nucleus of rats in response to immobilization stress, Brain Res Bull. 10:833 (1983).

    Article  PubMed  CAS  Google Scholar 

  75. J.P. Pascoe and B.S. Kapp, Electrophysiological characteristics of amygdaloid central nucleus neurons during Pavlovian fear conditioning in the rabbit, Behav Brain Res. 16:117 (1985).

    Article  PubMed  CAS  Google Scholar 

  76. J. Iwata, J.E. LeDoux, M.P. Meeley, S. Arneric, and D J. Reis, Intrinsic neurons in the amygdala field projected to by the medial geniculate body mediate emotional response conditioned to acoustic stimuli, Brain Res. 383:195 (1986).

    Article  PubMed  CAS  Google Scholar 

  77. M.H. Kellicut and J.S. Schwartzbaum, Formation of conditioned emotional response (CER) following lesions of the amygdaloid complex in rats, Psychol Rep. 12:351 (1963).

    Article  Google Scholar 

  78. A.A. Sperack, C.T. Campbell, and L. Drake, Effect of amygdalectomy on habituation and CER in rats, Physiol Behav. 15:199 (1975).

    Article  Google Scholar 

  79. J.M. Hitchcock and M. Davis, Lesions of the amygdala, but not of the cerebellum or red nucleus,block conditioned fear as measured by the potentiated startle paradigm, Behav Neurosci. 100:11 (1986).

    Article  PubMed  CAS  Google Scholar 

  80. C. Kim, H. Choi, J.K. Kim, M.S. Kim, H.J. Park, B.T. Ahn, and S.H. Kang, Influence of hippocampectomy on gastric ulcer in rats, Brain Res. 109:245 (1976).

    Article  PubMed  CAS  Google Scholar 

  81. H.M. Murphy, C.H. Wideman, and T.S. Brown, Plasma corticosterone levels and ulcer formation in rats with hippocampal lesions, Neuroendocrinology. 28:123 (1979).

    Article  PubMed  CAS  Google Scholar 

  82. P.G. Henke, R.J. Savoie, and B.M. Callahan, Hippocampal deafferentation and deefferentation and gastric pathology in rats, Brain Res Bull. 7:395 (1981).

    Article  PubMed  CAS  Google Scholar 

  83. R.A. Nicoll, J.A. Kauer, and R.C. Malenka, The current excitement in long-term potentiation,Neuron. 1:97 (1988).

    Article  PubMed  CAS  Google Scholar 

  84. D.G. Elmes, L.E. Jarrard, and P.D. Swart, Helplessness in hippocampectomized rats: Response perseveration?, Physiol Psychol. 3:51 (1975).

    Google Scholar 

  85. P.G. Henke, Synaptic efficacy in the entorhinal-dentate pathway and stress ulcers in rats, Neurosci Lett. 107:110 (1989).

    Article  PubMed  CAS  Google Scholar 

  86. P.G. Henke, N-methyl-D-aspartate receptors and stress ulcers in rats, in: “Stress and Gastrointestinal Motility,” L. Bueno, ed., John Libbey, London (1989).

    Google Scholar 

  87. P.G. Henke, Potentiation of inputs from the posterolateral amygdala to the dentate gyrus and resistance to stress ulcer formation in rats, Physiol Behav. 48:659 (1990).

    Article  PubMed  CAS  Google Scholar 

  88. P.G. Henke, Effects of naloxone on handling-induced modifications of hippocampal synaptic potentiation and stress ulcers in rats, Exp Clin Gastroenterol. 3:190 (1993).

    CAS  Google Scholar 

  89. B.R. Kaada, R.S. Feldman, and T. Langfeldt, Failure to modulate autonomic reflex discharge by hippocampal stimulation in rabbits, Physiol Behav. 7:225 (1971).

    Article  PubMed  CAS  Google Scholar 

  90. P.D. MacLean, Chemical and electrical stimulation of the hippocampus in unrestrained animals,Arch Neurol Psychiat. 81:331(1972).

    Google Scholar 

  91. C.E. Poletti, M. Kliot, and G. Boytin, Metabolic influences of the hippocampus on hypothalamus,preoptic and basal forebrain is exerted through amygdalofugal pathways, Neurosci Lett. 45:211 (1984).

    Article  PubMed  CAS  Google Scholar 

  92. R.E. Adamec and C. Stark-Adamec, Limbic hyperfunction, limbic epilepsy, and interictal behavior:Models and methods of detection, in: “The Limbic System,” B.K. Doane, K.E. Livingston, eds., Raven Press, New York (1986).

    Google Scholar 

  93. P.G. Henke, Hippocampal pathway to the amygdala and stress ulcer development, Brain Res Bull.25:691 (1990).

    Article  PubMed  CAS  Google Scholar 

  94. B.R. Kaada, Cingulate, posterior orbital, anterior insular and temporal pole cortex, in: “Handbook of Physiology, Section 1: Neurophysiology, Vol. 2,” J. Field, H.W. Magoun, V.E. Hall, eds., American Physiological Society, Washington, D.C. (1960).

    Google Scholar 

  95. P.D. MacLean, Culminating developments in the evolution of the limbic system: The thalamocingulate division, in: “The Limbic System,” B.K. Doane, K.E. Livingston, eds., Raven Press, New York (1986).

    Google Scholar 

  96. H.M. Richter, R.A. Davis, D. Ruge, and N.T. Walker, The effect of cortical and subcortical brain lesions upon gastric secretion in dogs with a vagus-preserved total gastric pouch, in: “Surgical Forum, Vol. 7,” American College of Surgeons, Chicago (1956).

    Google Scholar 

  97. E.L. Foltz and L.E. White, Pain “relief” by frontal cingulumotomy, J Neurosurg. 19:89 (1962).

    Article  PubMed  CAS  Google Scholar 

  98. P.G. Henke and R.J. Savoie, The cingulate cortex and gastric pathology, Brain Res Bull. 8:489 (1982).

    Article  PubMed  CAS  Google Scholar 

  99. L.W. Swanson, The anatomical organization of septo-hippocampal projections, in: “Functions of the Septo-Hippocampal System. Ciba Foundation Symposium 58 (new series),” Elsevier, Amsterdam (1978).

    Google Scholar 

  100. P.G. Henke, Mucosal damage following electrical stimulation of the anterior cingulate cortex and pretreatment with atropine and cimetidine, Pharmacol Biochem Behav. 19:483 (1983).

    Article  PubMed  CAS  Google Scholar 

  101. V.B. Domesick, Projections from the cingulate cortex in the rat, Brain Res. 12:296 (1969).

    Article  PubMed  CAS  Google Scholar 

  102. P.G. Henke, The anterior cingulate cortex and stress: Effects of chlordiazepoxide on unit-activity and stimulation-induced gastric pathology in rats, Int J Psychophysiol. 2:23 (1984).

    Article  PubMed  CAS  Google Scholar 

  103. P.G. Henke, R.M. Sullivan, A. Ray, and M.E. MacDougall, Stress ulcer modulation by chlordiazepoxide and GABA in the anterior cingulate cortex of rats, Exp Clin Gastroenterol. 2:13 (1992).

    CAS  Google Scholar 

  104. P.G. Henke, Chlordiazepoxide and stress tolerance in rats, Pharmacol Biochem Behav. 26:561 (1987).

    Article  PubMed  CAS  Google Scholar 

  105. R.M. Sullivan and P.G. Henke, The anterior midline cortex and adaptation to stress ulcers in rats,Brain Res Bull. 17:493 (1986).

    Article  PubMed  CAS  Google Scholar 

  106. J.A. Gray, N. Davis, J. Feldon, S. Owen, and M. Boarder, Stress tolerance: Possible neural mechanisms, in: “Foundations of Psychosomatics,” M.J. Christie, P.G. Mellet, eds., John Wiley & Sons, New York (1981).

    Google Scholar 

  107. A. Lenègre, I. Avril, and S. Fromage, Absence of amnesia induction in mice with hydroxyzine in comparison with three other minor tranquillizers, Arzneim Forsch/Drug Res. 38:558 (1988).

    Google Scholar 

  108. M.H. Thiébot, Some evidence for amnesia-like effects of benzodiazepines in animals, Neurosci Biobehav Rev. 9:95 (1985).

    Article  PubMed  Google Scholar 

  109. K.H. Pribram. “Languages of the Brain,” Prentice-Hall, Englewood Cliffs, N.J. (1971).

    Google Scholar 

  110. D.P. Crowne and D.D. Radcliffe, Some characteristics and functional relations of the electrical activity of the primate hippocampus and a hypothesis of hippocampal function, in: “The Hippocampus, Vol. 2,” R.L. Isaacson, K.H. Pribram, eds., Plenum Press, New York (1975).

    Google Scholar 

  111. J. Olds, The central nervous system and the reinforcement of behavior, Amer Psychol. 24:114 (1969).

    Article  CAS  Google Scholar 

  112. B. Milner, S. Corkin, and H.L. Teuber, Further analysis of the hippocampal amnesic syndrome:14-year follow-up study of H. M., Neuropsychologia. 6:215 (1968).

    Article  Google Scholar 

  113. P.G. Henke, A. Ray, and R.M. Sullivan, The amygdala: Emotions and gut functions, Digest Dis Sci. 36:1633 (1991).

    Article  PubMed  CAS  Google Scholar 

  114. P.G. Henke, Stomach pathology and the amygdala, in: “The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction,” J.P. Aggleton, ed., Wiley- Liss, New York (1992).

    Google Scholar 

  115. P.G. Henke and A. Ray, Review: The limbic brain, emotions and stress ulcers, Exp Clin Gastroenterol. 1:287 (1992).

    Google Scholar 

  116. P.G. Henke and A. Ray, Stress ulcer modulation by limbic system structures, Acta Physiol Hung.80:117(1992).

    PubMed  CAS  Google Scholar 

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  1. Peter G. Henke
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Editors and Affiliations

  1. Harvard Medical School, Boston, Massachusetts, USA

    Sandor Szabo

  2. Irvine VA Medical Center, University of California, Long Beach, California, USA

    Sandor Szabo

  3. Center for Ulcer Research and Education, University of California, Los Angeles, California, USA

    Yvette Taché

  4. University of Manitoba, Winnipeg, Manitoba, Canada

    Gary B. Glavin

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Henke, P.G. (1995). The Limbic System and Stress Ulcers. In: Szabo, S., Taché, Y., Glavin, G.B. (eds) Neuroendocrinology of Gastrointestinal Ulceration. Hans Selye Symposia on Neuroendocrinology and Stress, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1867-9_15

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  • DOI: https://doi.org/10.1007/978-1-4615-1867-9_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5759-9

  • Online ISBN: 978-1-4615-1867-9

  • eBook Packages: Springer Book Archive

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