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Aids as Immune System Activation

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Cell Activation and Apoptosis in HIV Infection

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 374))

Abstract

Since 1987, when we first formulated the hypothesis that AIDS and HIV disease are the result of inappropriate immune system activation triggered by viral gp 120 signalling at CD4 [1-3], the concept has been supported by several developments. First is a better understanding of the natural history of HIV disease. Second is the elucidation of the role of CD4 in T cell activation. Third is the appreciation of the prominent role of programmed cell death or apoptosis in the normal dynamic equilibrium of the immune system. Last is the failure of antiviral strategies to affect the clinical course of disease in infected individuals.

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Authors and Affiliations

  1. Viral and Rickettsial Disease Laboratory, California Department of Health Services, Berkeley, California, 94704, USA

    Michael S. Ascher, Haynes W. Sheppard, John F. Krowka & Hans J. Bremermann

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  1. Michael S. Ascher
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  2. Haynes W. Sheppard
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  3. John F. Krowka
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  4. Hans J. Bremermann
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  1. Laennec Hospital, Paris, France

    Jean-Marie Andrieu  & Wei Lu  & 

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Ascher, M.S., Sheppard, H.W., Krowka, J.F., Bremermann, H.J. (1995). Aids as Immune System Activation. In: Andrieu, JM., Lu, W. (eds) Cell Activation and Apoptosis in HIV Infection. Advances in Experimental Medicine and Biology, vol 374. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1995-9_17

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