Abstract
The tear film provides a barrier against pathogenic invasion of the ocular surface. One component of this defense is secretory immunoglobulin A (S-IgA), the predominant immunoglobulin in tears in many species, which is known to be inhibitory for bacterial adhesion.1 IgA is produced by lacrimal gland plasma cells and then transported to the tears by transcytosis following an interaction with secretory component expressed on the surface of epithelial cells. In the mucosal immune network, the precursors of IgA producing plasma cells migrate from sites of antigen encounter to distal mucosal sites such as lacrimal glands. T cells are involved in regulating mucosal immunity and are also retained in the lacrimal gland. The purpose of this study was to further delineate mechanisms responsible for the preferential accumulation of specific lymphoid populations in lacrimal glands.
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O’Sullivan, N.L., Raja, R., Montgomery, P.C. (1994). Lymphocyte Adhesive Interaction with Lacrimal Gland Acinar Epithelium Involves Carbohydrate Recognition. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_31
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DOI: https://doi.org/10.1007/978-1-4615-2417-5_31
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