Abstract
It is an honor and a pleasure to contribute to and participate in this prestigious course at the University Complutense, directed by the eminent scientist and teacher Dr. Santiago Grisolia. The topic of the course, dealing with the relationships of excess ammonia, liver pathology, and brain deficiency, indicates the interrelationships of the various organs in the body, and also indicates the need for us to identify the processes that are unique to an organ or are of special significance for it. One reason for selecting protein breakdown for discussion was its important relationship to ammonia, its products — amino acids. In general, only 0.1 to 1.0 percent of the amino acids are in the free amino acid pool as compared to the protein-bound forms; therefore, breakdown of only one percent of the proteins would increase the content in the free pool 2–10 fold. Therefore, protein breakdown could have an important influence on ammonia metabolism.
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Lajtha, A. (1993). Controls of Cerebral Protein Breakdown. In: Grisolía, S., Felipo, V. (eds) Cirrhosis, Hyperammonemia, and Hepatic Encephalopathy. Advances in Experimental Medicine and Biology, vol 341. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2484-7_10
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DOI: https://doi.org/10.1007/978-1-4615-2484-7_10
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