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Ionic Channels in Type I Carotid Body Cells

  • Chapter
Arterial Chemoreceptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 360))

Abstract

Over many years, a wealth of neurochemical and histological studies have established that type I (or glomus) cells, which lie in synaptic contact with afferent chemosensory nerve endings within the carotid body, are the primary sites of chemodetection. These cells contain various neurotransmitters (dopamine generally being accepted as the most important) which are released in response to both physiological and pharmacological stimuli. The good correlation between stimulus intensity, transmitter release and afferent chemosensory nerve discharge strongly suggests that release of transmitter(s) from type I cells is a fundamental step in the transduction of chemostimuli in the carotid body (Fidone & Gonzalez, 1986; Fidone et al., 1990; Gonzalez et al, 1992).

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Authors and Affiliations

  1. Department of Pharmacology, Leeds University, Leeds, UK

    Chris Peers

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  1. Chris Peers
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Editors and Affiliations

  1. University College Dublin, Dublin, Ireland

    Ronan G. O’Regan  & Philip Nolan  & 

  2. University of Edinburgh Medical School, Edinburgh, Scotland

    Daniel S. McQueen

  3. University of Oxford, Oxford, UK

    David J. Paterson

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© 1994 Springer Science+Business Media New York

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Peers, C. (1994). Ionic Channels in Type I Carotid Body Cells. In: O’Regan, R.G., Nolan, P., McQueen, D.S., Paterson, D.J. (eds) Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol 360. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2572-1_4

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  • DOI: https://doi.org/10.1007/978-1-4615-2572-1_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6099-5

  • Online ISBN: 978-1-4615-2572-1

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