Abstract
A number of aldehyde dehydrogenase isozymes are distinguished based on the separation by physicochemical methods,, tissue and subcellular distributions, and enzymatic properties. Although ALDH isozymes are usually assayed with short chain aliphatic aldehydes as substrate, they exhibit relatively broad substrate specificities and can oxidize various biogenic and xenobiotic aliphatic and aromatic aldehydes including dopaldehyde and aminaldehydes. However, their physiological substrates are not identified and the primary biological roles of individual ALDH isozymes are not yet clear.
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Yoshida, A., Hsu, L.C., Yanagawa, Y. (1993). Biological Role of Human Cytosolic Aldehyde Dehygrogenase 1: Hormonal Response, Retinal Oxidation and Implication in Testicular Feminization. In: Weiner, H., Crabb, D.W., Flynn, T.G. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 4. Advances in Experimental Medicine and Biology, vol 328. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2904-0_5
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DOI: https://doi.org/10.1007/978-1-4615-2904-0_5
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