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Gadolinium as an Element for Neutron Capture Therapy

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Advances in Neutron Capture Therapy

Abstract

Gadolinium is being studied as an alternate active element to B for Neutron Capture Therapy (NCT). The advantages of Gd-157 as compared to B-10 are that Gd-157 has a very large thermal neutron cross section (455,000 b), and Gd containing compounds that target tumors are being developed as MRI contrast agents. A disadvantage is that the products of the Gd + n reaction, gamma rays and Auger electrons, do not appear to be as well suited to NCT as the products of the B + n reaction, but these still may be effective in destroying tumors. Because of the advantages of Gd, an investigation of Gd as an element for NCT is proceeding at Brookhaven National Laboratory (BNL)1.

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References

  1. R. Brugger, S. Gibb, J-L. Shih, S. Pickup, X. Luo, J. Oro, and B. Laster. “Estimated Doses by Gadolinium Neutron Capture Therapy.” Proceedings of the International Workshop on Marco and Micro Dosimetry and Treatment Planning for Neutron Capture Therapy, editors, O.H. Harling, R.G. Zamenhof, and G.R. Solares (to be published) July 1991

    Google Scholar 

  2. J.A. Shih and R.M. Brugger. “Gadolinium as a Neutron Capture Therapy Agent,” Medical Physics 19(3), (May/June 1992).

    Google Scholar 

  3. J.A. Shih and R.M. Brugger. “Neutron Induced Brachytherapy: A Combination of Neutron Capture Therapy and Brachytherapy,” Medical Physics, 19, pp.369–376 (1992).

    Article  PubMed  CAS  Google Scholar 

  4. S.B. Kahl and M-S. Koo. “Synthesis and Properties of Tetrakis-CarboraneCarboxylate Esters of 2,4-Bis-(α,β-Dihydroxyethyl) Deuteroporphyrin IV Progress in Neutron Capture Therapy for Cancer, editors, B.J. Allen, D.E. Moore, and B.V. Harrington, pp. 223–226 (1192)

    Google Scholar 

  5. M. Miura, P.L. Micca, J.C. Heinrichs, D. Gabel, R.G. Fairchild, and D.N. Slatkin. “Biodistribution and Toxicity of 2,4-Dioinyl Nido-oCarbonan yldeuteroporphyrin IX in Mice,” Biochemical Pharmacology 43: 467–476 (1992).

    Article  PubMed  CAS  Google Scholar 

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© 1993 Springer Science+Business Media New York

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Brugger, R.M., Liu, H.B., Laster, B.H., Gordon, C.R., Greenberg, D.D., Warkentien, L.S. (1993). Gadolinium as an Element for Neutron Capture Therapy. In: Soloway, A.H., Barth, R.F., Carpenter, D.E. (eds) Advances in Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2978-1_45

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  • DOI: https://doi.org/10.1007/978-1-4615-2978-1_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6296-8

  • Online ISBN: 978-1-4615-2978-1

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