Abstract
Several years ago, Weinberg and Bell (1, 2) demonstrated the feasibility of developing models of the vascular wall in which smooth muscle cells (SM) were embedded within a 3-dimensional collagen lattice and the lattice then overlaid with a layer of endothelial cells (EC). They went on to form a model containing adventitial cells surrounding a tubular composite lattice and showed that under these conditions, the cells maintained certain of their phenotypic properties. Since that time, it has become evident that the composition of the extracellular environment may have important effects upon the properties of cells and that cell-cell and cell-matrix interactions are of vital importance in the physiology of most tissues (3, 4).
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© 1992 Springer Science+Business Media New York
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Alper, R., Kefalides, N.A. (1992). Properties of Endothelial and Smooth Muscle Cells Grown in 3-Dimensional Collagen Lattices. In: Maragoudakis, M.E., Gullino, P., Lelkes, P.I. (eds) Angiogenesis in Health and Disease. NATO ASI Series, vol 227. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3358-0_12
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DOI: https://doi.org/10.1007/978-1-4615-3358-0_12
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