Skip to main content
SpringerLink
Log in

Effects of Cyclopiazonic Acid, an Inhibitor of the Ca++ Atpase of Sarcoplasmic Reticulum, on Ca++ Transport, Contraction and Relaxation in Cardiac Muscle

  • Chapter
Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 311))

Summary

Cyclopiazonic acid is a potent inhibitor of cardiac sarcoplasmic reticulum Ca++ ATPase. It scarcely affects inotropism but significantly impairs lusitropism suggesting a greater role for cardiac sarcoplasmic reticulum in the control of cardiac relaxation than in the control of cardiac contraction.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. D. E. Goeger, R. T. Riley, J. W. Dorner, and R. J. Cole, Cyclopiazonic acid inhibition of the Ca2+-transport ATPase in rat skeletal muscle sarcoplasmic reticulum vesicles, Biochem. Pharmacol., 37:978 (1988).

    Article  PubMed  CAS  Google Scholar 

  2. N. W. Seidler, I. Jona, M. Vegh, and A. Martonosi, Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum, J.Biol.Chem., 264:17816 (1989).

    PubMed  CAS  Google Scholar 

  3. L. R. Jones, H. R. Besch, J. W. Fleming, M. McConnaughey, and A. M. Watanabe, Separation of vesicles of cardiac sarcolemma from vesicles of cardiac sarcoplasmic reticulum, J.Biol.Chem., 254:530 (1979).

    PubMed  CAS  Google Scholar 

  4. A. Fabiato, Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands, Meth. Enzym., 157:378 (1988).

    Article  PubMed  CAS  Google Scholar 

  5. E. J. Krane, and J. Y. Su, Comparison of the effects of halothane on skinned fibers from newborn and adult rabbits: II. Effects on sarcoplasmic reticulum, Anesthesiology, 71:103 (1989).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. SmithKline Beecham Laboratoires Pharmaceutiques, BP 58, F-35762, St. Gregoire Cedex, France

    Philippe Lahouratate & Marie Josée Quiniou

  2. UA CNRS 1340, Laboratoire de Physiologie Générale, ENV, F-44087, Nantes Cedex 03, France

    Claude Léoty

Authors
  1. Philippe Lahouratate
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marie Josée Quiniou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Claude Léoty
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Alberta, Edmonton, Alberta, Canada

    George B. Frank

  2. Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    C. Paul Bianchi

  3. University of Calgary, Calgary, Alberta, Canada

    Henk E. D. J. ter Keurs

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media New York

About this chapter

Cite this chapter

Lahouratate, P., Quiniou, M.J., Léoty, C. (1992). Effects of Cyclopiazonic Acid, an Inhibitor of the Ca++ Atpase of Sarcoplasmic Reticulum, on Ca++ Transport, Contraction and Relaxation in Cardiac Muscle. In: Frank, G.B., Bianchi, C.P., ter Keurs, H.E.D.J. (eds) Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 311. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3362-7_33

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3362-7_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6483-2

  • Online ISBN: 978-1-4615-3362-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation