Abstract
Long term lymphoid cell cultures from fetal liver and bone marrow1 have been used to study T- and B-lymphocyte development ‘in vitro’ and by repopulation experiments of suitable hosts ‘in vitro’2. Cell contacts between the progenitors of lymphocytes and stromal cells, as well as cytokines produced upon these contacts3 were found to be required for lymphopoiesis, specifically of the B-lymphocyte lineage4-6. Multiple contacts between stromal cells and progenitors have since been identified in this adhesion7-11. These early forms of progenitor and precursor cultures set the stage and raised the hope to dissect the hierarchy of hemopoietic-lymphopoietic differentiation to clone the differently committed cells, and to determine their capacity to proliferate and to differentiate.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
K.A. Denis and O.N. Witte, Long-term lymphoid cultures in the study of B cell differentiation, in: “Immunoglobulin Genes”, T. Honjo, F.W. Alt and T.H. Rabbits, eds., Academic Press, New York (1989).
R.A. Phillips, Development and regulation of the lymphocyte lineages: an interpretative overview, Progr. Immunol. 7:305 (1989).
A.E. Namen, S. Lupton, K. Hjerrild, I. Wagnall, D.Y. Mochuzuki, A. Schmierer, B. Mosley, C. March, D. Urdal, S. Gillis, D. Cosman and R.G. Goodwin, Stimulation of B cell progenitors by cloned murine interleukin 7, Nature 333:571 (1988).
P.W. Kincade, G. Lee, C.E. Pietrangeli, S.i. Hayashi and I.M. Gimble, Cells and molecules that regulate B-lymphopoiesis in bone marrow, Ann. Rev. Immunol. 7:111 (1988).
K. Dorshkind, Regulation of hemopoiesis by bone marrow stromal cells and their products, Ann. Rev. Immunol. 8:111 (1990).
A. Rolink and F. Melchers, Molecular and cellular origins of B lymphocyte diversity, Cell 66:1081 (1991).
R.D. Sanderson, P. Lalor and M. Bernfield, B lymphocytes express and lose syndecan at specific stages of differentiation, Cell Reg. 1:27 (1989).
P.S. Thomas, C.E. Pietangeli, S.I. Hayashi, M. Schachner, C. Goridis, M. Low and P.W. Kincade, Demonstration of neural cell adhesion molecules on stromal cells which support lymphopoiesis, Leukemia 2:171 (1988)
P. Bernardi, V.P. Patel and H.F. Lodish, Lymphoid precursor cells adhere to two different sites on fibronectin. J. Cell. Biol. 105:489 (1988).
K. Miyake, C.B. Underhill, J. Lesley and P.W. Kincade, Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. J. Exp. Med. 172:69 (1990).
K. Miyake, I.L. Weissman, J.S. Greenberger and P.W. Kincade, Evidence for a role of the integrin VLA-4 in lymphohemapoiesis. J. Exp. Med. 173:599 (1991).
L.S. Collins and K. Dorshkind, A stromal cell line from myeloid long-term bone marrow cultures can support myelopoiesis and B lymphopoiesis. J. Immunol. 138:1082 (1987).
C.A. Whitlock, G.F. Tidmarsh, C. Müllier-Sieburg and I.L. Weissman, Bone marrow stomal cell lines with lymphopoietic activity express high levels of a pre-B neoplasia-associated molecule. Cell 48:1009 (1987).
S.I. Nishikawa, M. Ogawa, S. Nishikawa, T. Kumisada and H. Kodama, B lymphopoiesis on stromal cell clones: stromal cell clones acting on different stages of B cell differentiation. Eur. J. Immunol. 18:1767 (1988).
T. Era, M. Ogawa, S.I. Nishikawa, M. Okamoto, T. Honjo, K. Akagi, J.I. Migazaki and K.I. Yamamura, Differention of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin. EMBO J. 10:337 (1991).
S.I. Hayashi, T. Kunisada, M. Ogawa, T. Sudo, H. Kodama, T. Suda, T. Nishikawa and S.I. Nishikawa, Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules. J. Exp. Med. 171:1683 (1990).
A. Rolink, A. Kudo, H. Karasuyama, Y. Kikuchi and F. Melchers, Long-term proliferating early pre-B cell lines and clones with the potential to develop to surface Ig-positive, mitogen-reactive B cells in vitro and in vivo. EMBO J. 10:327 (1991).
P. Besmer, J.E. Murphy, J.P.C. George, F. Qui, P.J. Bergold, L. Lederman and H.W. Snyder Jr., A new acute transforming feine retrovirus and relationship of its oncogene v-kit with the protein kinase family. Nature 320:415 (1986).
B. Chabot, D.A. Stephenson, V.M. Chapman, P. Besmer and A. Bernstein, The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335:88 (1988).
E.N. Geissler, M.A. Ryan and D.E. Housman, The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 55:185 (1988).
J.C. Tau, K. Nocka, P. Ray, P. Traktman and P. Besmer, The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase. Science 247:209 (1990).
K. Nocka, J. Tau, E. Chiu, T.Y. Chu, P. Ray, P. Traktman and P. Besmer, Molecular basis of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, WV, W41 and W. EMBO J. 9:1805 (1990).
D. Bennett, Developmental analysis of a mutation with pleiotropic effects in the mouse. J. Morphol 98:199 (1956).
O.W. Witte, Steel locus defines new multipotent growth factors. Cell 63:5–6 (1990).
M. Ogawa, Y. Matsuzaki, S. Nishikawa, S.I. Hayashi, T. Kunisada, T. Sudo, T. Kina, H. Nakauchi and S.I. Nishikawa, Expression and function of ckit in hemopoietic progenitor cells. J. Exp. Med. 174:63 (1991).
A. Rolink, M. Streb, S.I. Nishikawa and F. Melchers, The c-kit-encoded tryrosine kinase regulates the proliferation of early pre-B cells, Eur. J. Immunol. 21:2609 (1991).
Y. Shinkai, G. Rathbun, K.-P. Lam, E.M. Oltz, V. Stewart, M. Mendelsohn, J. Charon, M. Datta, F. Young, A.M. Stall and F.W. Alt, RAG-2 deficient mice lack mature lymphocytes due to inability to initiate VDJ rearrangement. Cell in press.
A. Rolink, M. Streb and F. Melchers, The κλ ratio in surface immunoglobulin molecules on B lymphocytes differentiating from DHJH-rearranged murine pre-B cell clones in vitro, Eur. J. Immunol. 21:2895 (1991).
K.L. Maguire and E.S. Vietta, κ/λ shifts do not occur during maturation of murine B cells. J. Immunol. 127:1670 (1981).
S. Kessler, K.J. Kim and I. Scher, Surface membrane κ and λ light chain expression on spleen cells of neonatal and maturing normal and immune-defective CBAIN mice: The κ:λ. ratio is constant. J. Immunol. 127:1674.(1981)
T. Takemori and K. Rajewsky, Lambda chain expression at different stages of ontogeny in C57BL/6, BALB/c and SJL mice. Eur. J. Immunol. 11:618 (1981).
J.M. LeJeune, D.E. Briles, A.R. Lawton and J.F. Kearney, Estimate of the light chain repertoire size of fetal and adult BALB/cJ and CBA/J mice. J. Immunol. 129:673.(1982)
H. Sauter and C.J. Paige, Detection of normal B-cell precursors that give rise to colonies producing both κ and λ light immunoglobulin chains. Proc. Natl. Acad. Sci. USA 84:4898 (1987).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Melchers, F., Haasner, D., Streb, M., Rolink, A. (1992). B-Lymphocyte Lineage-Committed, IL-7 and Stroma Cell- Reactive Progenitors and Precursors, and Their Differentiation to B Cells. In: Gupta, S., Waldmann, T.A. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation IV. Advances in Experimental Medicine and Biology, vol 323. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3396-2_14
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3396-2_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6500-6
Online ISBN: 978-1-4615-3396-2
eBook Packages: Springer Book Archive