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Recombinant Human Nerve Growth Factor Increases Presynaptic Cholinergic Function Following Neuronal Damage: Implications for the Treatment of Alzheimer’s Disease

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Treatment of Dementias

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 40))

Abstract

Nerve growth factor (NGF) promotes the maintenance of function and survival of adult cholinergic neurons of the septo-hippocampal pathway and attenuates lesion-induced deficits in neurochemical and behavioral measures related to cholinergic septo-hippocampal functions (Hefti et al., 1984; Will and Hefti, 1985; Williams et al, 1986, 1989; Will et al., 1988, 1990; Lapchak and Hefti, 1991).

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Lapchak, P.A., Hefti, F. (1992). Recombinant Human Nerve Growth Factor Increases Presynaptic Cholinergic Function Following Neuronal Damage: Implications for the Treatment of Alzheimer’s Disease. In: Meyer, E.M., Simpkins, J.W., Yamamoto, J., Crews, F.T. (eds) Treatment of Dementias. Advances in Behavioral Biology, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3432-7_12

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  • DOI: https://doi.org/10.1007/978-1-4615-3432-7_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6518-1

  • Online ISBN: 978-1-4615-3432-7

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