Abstract
Specific regions of brain are known to be especially vulnerable to various insults such as ischemia [Spielmeyer, 1925; Brown and Brierley, 1968]. Patients resuscitated from cardiac arrest often suffer from memory impairment. Even a short cessation of cerebral circulation causes damage to the hippocampus, which is critical to memory function [Brierly and Graham, 1984; Petito, 1984]. Delayed neuronal death of the hippocampus was originally described in rodents model of transient global ischemia [Ito et al. 1975; Kirino, 1982; Pulsinelli et al. 1982]. In gerbils, only 5 minutes of bilateral carotid artery occlusion causes selective neuronal death of the hippocampal CAl sector [Kirino, 1982].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aloe L (1988) Intracerebral pretreatment with nerve growth factor prevents irreversible brain lesions in neonatal rats injected with ibotenic acid. Biotechnology 5: 1085–1086.
Barnes DM (1988a) Cells without growth factors committed suicide. Science 242: 1510–1511.
Barnes DM (1988b) NMDA receptors trigger excitement. Science 239: 254–256.
Brierley JB, Graham DI (1984) Hypoxia and vascular disorders of the central nervous system. London: Edward Arnold, (pp. 125–207 ).
Brown A, Brierley J (1968) The nature, distribution, and earliest stages of anoxicischemic nerve cell damage in the rat brain as defined by the optical microscope. Br J Exp Pathol 49: 87–106.
Buck CR, Martinez HJ, Chao MD, Black IB (1988) Differential expression of the nerve growth factor receptor in multiple brain areas. Dev Brain Res 44: 259–268.
Bust R, Dietrich WD, Globus MYT, Ginsberg MD (1989) Postischemic moderate hypothermia inhibits CA1 hippocampal ischemic neuronal injury. Neurosci Lett 101: 299–304.
Bust R, Dietrich WD, Globus MYT, Valdes I, Scheinberg P, Ginsberg MD (1987) Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 44: 259–268.
Choi DW, Rothmann SM (1990) The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci 13: 171–182.
Dienel GA, Kiessling M, Jacewicz M, Pulsinelli WA (1986) Synthesis of heat shock proteins in rat brain cortex after transient ischemia. J Cereb Blood Flow Metab 6:505– 510.
Dienel GA, Plusinelli WA, Duffy TE (1980) Regional protein synthesis in the rat brain following acute hemispheric ischemia. J Neurochem 35: 1216–1226.
Fischer W, Wictorin K, Björklund A, Williams LR, Varon S, Gage FH (1987) Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329: 65–68.
Furukawa S, Kano I, Furukawa Y, Akazawa S, Satoyoshi E, Itoh K, Hayashi K (1983) A highly sensitive enzyme immunoassay for mouse ß nerve growth factor. J Neurochem 40: 734–744.
Furukawa S, Furukawa Y, Satoyoshi E, Hayashi K (1986a) Synthesis and secretion of nerve growth factor by mouse astroglial dells in culture. Biochem Biophys Res Commun 136: 57–63.
Furukawa S, Furukawa Y (1990) Nerve growth factor synthesis and its regulatory mechanisma: an approach to therapeutic induction of nerve growth factor synthesis. Cerebrovas and Brain Metab Rev 2: 328–344.
Furukawa Y, Furukawa S, Satoyoshi E, Hayashi K (1986b) Catecholamines induce an increase in nerve growth factor content in the medium of mouse L-M cells. J Biol Chem 261: 6039–6047.
Furukawa Y, Fukazawa N, Miyama Y, Hayashi K, Furukawa S (1990) Stimulatory effect of 4-alkylcatechols and their diacetylated derivatives on the synthesis of nerve growth factor. Biochem Pharmacol 40: 2337–2342.
Gill R, Foster AC, Woodruff GN (1987) Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil. J Neurosci 7: 3343–3349.
Hefti F, Dravid A, Hartikka J (1984) Chronic intraventricular injections of nerve growth factor elevate hippocampal acetylcholine transferase activity in adult rats with partial septohippocampal lesions. Brain Res 1984: 305–311.
Hefti F, Weiner WJ (1986) Nerve growth factor and Alzheimer’s disease. Ann Neurol 20: 275–281.
Ishikawa R, Nishikiori K, Furukawa S (1991) Appearance of nerve growth factor and acidic fibroblast growth factor with different time courses in the cavity-lesioned cortex of the brain. Neurosci Lett 56: 836–841.
Ito U, Spatz M, Walker JT Jr, Klatzo l (1981) Experimental cerebral ischemia in Mongolian gerbils. I. Light microscopis observations. Acta Neuropathol (Berl) 32:209– 223.
Jørgensen MB, Decker J, Wright DC, Gehlert DR (1989) Delayed c-fos proto-oncogene expression in the rat hippocampus induced by transient global cerebral ischemia: an in situ hybridization study. Brain Res 484: 393–398.
Kervin J, Morris C, Oakley A, Perry R, Perry E (1991) Distribution of nerve growth factor receptor immunoreactivity in the human hippocampus. Neurosci Lett 121:178– 182.
Kiessling M, Xie Y, Ullrich B, Thilmann R (1991) Are the neuroprotective effect of the protein synthesis inhibitor cycloheximide due to prevention of apoptosis? J Cereb Blood Flow Metab 11 Suppl: S357.
Kirino T (1982) Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 239: 57–69.
Korshing S, Auburger G, Heuman R, Scott J, Thoenen H (1985) Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation. EMBO 4: 1389–1393.
Kromer LF (1987) Nerve growth factor treatment after brain injury prevents neuronal death. Science 235: 214–216.
Large TH, Bodary SC, Clegg DO, Weskamp G, Otten U, ReichardtLF (1986) Nerve growth factor gene expression in the developing rat brain. Science 234: 352–355.
Levi-Montalcini R (1987) The nerve growth factor 35 years later. Science 237: 1154–1162.
Lorez H, Keller F, Ruess G, Otten U (1989) Nerve growth factor increase in adult rat brain after hypoxic injury. Neurosci Lett 98: 339–344.
Lu B, Buck CR, Dreyfus CF, Black IB (1989) Expression of NGF and NGF receptor mRNAs in the developing brain: evidence for local delivery and action of NGF. Exp Neurol 104: 191–199.
Magnusson K, Wieloch T (1989) Impairment of ubiquitization may cause delayed neuronal death. Neurosci Lett 96: 264–270.
Martin DP, Schmidt RE, DiStefano PS, Lowry OH, Carter JG, Johnson EM Jr (1988) Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J Cell Biol 106: 829–844.
Marx JL (1986) Nerve growth factor acts in brain. Science 232: 1341–1342.
Matsui K, Furukawa S, Shibasaki H, Kikuchi T (1990) Reduction of nerve growth factor level in the brain of genetically ataxic mice (weaver, reeler). FEBS Lett 276:78– 80.
Montero CN, Hefti F (1989) Intraventricular nerve growth factor administration prevents lesion-induced loss of septal cholinergic neurons in aging rats. Neurobiol Aging 10: 739–743.
Nadler JV, Perry BW, Cotman CW (1978) Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells. Nature 271: 676–677.
Nieto-Sampedro M, Lewis ER, Cotman CW, Manthorpe M, Skaper SD, Barbin G, Longo FM, Varon S (1982) Brain injury causes a time-dependent increase in neurotrophic activity at the lesion site. Science 217: 860–861.
Nieto-Sampedro M, Lim R, Hicklin DJ, Cotman CW (1988) Early release of glia maturation factor and acidic fibroblast growth factor after rat brain injury. Neurosci Lett 86: 361–365.
Nowak TS Jr (1985) Synthesis of a stress protein following transient ischemia in the gerbil. J Neurochem 45: 1635–1641.
Nowak TS Jr, Bond U, Schlesinger MJ (1990) Heat shock RNA levels in brain and other tissues after hyperthermia and transient ischemia. J Neurochem 54: 451–458.
Oppenheim RW, Harverkamp LJ, Prevette D, McManaman JL, Appel SH (1988) Reduction of naturally occurring motoneuron death in vivo by a target-derived neurotrophic factor. Science 240: 919–922.
Petito CK, Feldmann E, Pulsinelli WA, Plum F (1987) Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology 37: 1281–1286.
Pulsinelli WA, Brierley JB, Plum F (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11: 491–498.
Raivich G, Kreutzberg GW (1987) The localization and distribution of high affinity ß-nerve growth factor binding sites in the central nervous system of the adult rat. A light microscopic autoradiographic study using [125I] β-nerve growth factor. Neuroscience 20: 23–36.
Richardson PM, Verge Issa VMK, Riopelle RJ (1986) Distribution of neuronal receptors for nerve growth factor in the rat. J Neurosci 6: 2312–2321.
Rosenberg MB, Friedmann T, Robertson RC, Tuszynski M, Wolff JA, Breakefield XO, Gage FH (1988) Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression. Science 242: 1575–1578.
Shigeno T, Mima T, Takakura K, Graham DI, Kato G, Hashimoto Y, Furukawa S (1991) Amelioration of delayed neuronal death in the hippocampus by nerve growth factor. J Neurosci 11: 2914–2919.
Shigeno T, Yamasaki Y, Kato G, Kusaka K, Mima T, Takakura K, Graham DI, Furukawa S (1990) Reduction of delayed neuronal death by inhibition of protein synthesis. Neurosci Lett 120: 117–119.
Siejö BK (1981) Cell damage in the brain: a speculative synthesis. J Cereb Blood Flow Metab 1: 155–185.
Spielmeyer W (1925) Zur Pathogenese der örtlich elecktiven Gehimveränderungen. Z Neurol Psychiatr 99: 756–777.
Thilman R, Xie Y, Kleinhaus P, Kiessling M (1986) Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus. Acta Neuropathol (Berl) 71: 88–93.
Vass K, Welch WJ, Nowak TS Jr (1988) Localization of 70-kDa stress protein induction in gerbil brain after ischemia. Acta Neuropthol (Berl) 77: 128–135.
Yoshimine T, Hayakawa T, Yamamoto S, Kimura E, Iris T, Fujioka K (1990) Effect of nerve growth factor on the development of postischemic neuronal death. Paper presented at the 9th International Congress of Neuropathology ( Kyoto, Japan )
Yost HJ, Lindquist S (1988) Translation of unspliced transcripts after heat shock. Science 1988: 1544–1548.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Mima, T. et al. (1992). Delayed Neuronal Death of Hippocampus (CA1) After Transient Global Ischemia: Does Nerve Growth Factor Protect Neurons Against “Killer Proteins” ?. In: Meyer, E.M., Simpkins, J.W., Yamamoto, J., Crews, F.T. (eds) Treatment of Dementias. Advances in Behavioral Biology, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3432-7_13
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3432-7_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6518-1
Online ISBN: 978-1-4615-3432-7
eBook Packages: Springer Book Archive